Environmental-Toxicology Flashcards
What controls thermoregulation?
> Hypothalamus controls thermal regulation by conserving heat and producing heat.
it virtually affects every system, but significantly affects cardiovascular in CNS systems.
Cardiac effects of hypothermia
> bradycardia(epi & atropine will not help)
decreased MAP and CO
Osborne waves( J waves) positive deflection at J point. Seen best in lateral leads.
atrial/ventricular arrhythmias
The height of the J wave equals the degree of hypothermia
CNS effects of hypothermia
> Decreasing metabolism(decreasing oxygen consumption)
Core temp <33°C, electrical activity becomes abnormal
core temp between 19-20°C, EEG may show brain death
Mild hypothermia
> 32 to 35°C (89.6 to 95°F)
Vigorous shivering
May develop altered judgment or dysarthria
respiratory rate may increase
Ataxia/apathy as temperature decreases
tachypnea/tachycardia
Cold diuresis (kidneys are resistant and don’t work well)
Moderate hypothermia
> 28 to 32°C (82.4 to 89.6°F)
O2 consumption decreases
Further CNS depression
stupor/ confusion may occur
loss of shivering
arrhythmia risk increases
bradycardia worsens
cardiac output reduces
dilation of the pupils
Paradoxical undressing
Severe hypothermia
> <28°C (<82.4°F)
susceptible to Vfib
further decrease in myocardial contractility
comatose
pulmonary edema
oliguria
hypotension
decreased/absent activity on EEG
Hypothermia treatment
> Prevent further heat loss
Rewarm Core-temp
Avoid arrhythmias
Avoid inadvertent jerking movements
Monitor for complications
Hypotension is normal, fluid resuscitation is needed.
Watch for hypoglycemia, and treat accordingly.
Thiamine might be helpful
Avoid nasal gastric tube placement
Defibrillate once, but defer all other ALS treatment until Core temp is > 30°C.
Passive external rewarming
> move to warm dry environment
provide insulation
must have intact the regulatory mechanisms
Active external rewarming
> application of heat to the skin
must have intact circulation
Hot water bottles and heating pads
forced air warming systems
you may see Core-temp after drop. You may see increase in acidosis and core temp dropping again.
Active core rewarming
> heated, humidified O2
heated IV fluids
warm lavage of cavities
extra corporeal blood rewarming(echmo)
resuscitative efforts continue until core temp reaches 30 to 32°C (89.6°F)
Hyperthermia
A life-threatening condition characterized by failure of the body to regulate or dissipate heat
Defined as a core of greater than 38.5°C(101 .3°F)
Heat cramps
> mildest form of heat illness; core temp is normal
cause painful muscle cramps/spasms
flushed, moist skin
normally occurs during or after intense exercise/sweating
Heat cramps treatment
> Moved to a cool environment
remove excess clothing
hydration
stretching
Heat exhaustion
> Core temp >38°C( 100.4°F)
muscle cramp
pale, moist skin
N/V/D
HA
fatigue or weakness
feeling faint
Heat exhaustion treatment
> same measures as with heat cramps
humidified O2
cool IV fluid(LR or NS)
check glucose and treat as needed.
Heat stroke
> most severe form of Hyperthermia
Core temp >40°C(104°F)
hot dry skin
rhabdomyolysis
renal failure
worsening CNS symptoms
Heat stroke treatment
> same as heat exhaustion
initiate rapid active cooling
cold water immersion
body temp should be lowered to at least 102°F
remove clothing and cover with sheets, soaked and room temperature water
manage airway is needed
Malignant hyperthermia
> calcium is released into muscle fibers, causing sustained contraction due to rapid depolarization
causes muscle rigidity in excessive heat production
activation of sympathetic nervous system
hyperkalemia
can ultimately lead to DIC and MODS
most often associated with the use of succinylcholine
trismus
increased ET CO2
mixed acidosis
rhabdomyolysis
truncal or extremity rigidity
Malignant hyperthermia treatment
> Dantrolene Na+ 2.5mg/kg. Max 20mg/kg
cool if temp is >39°C
treat dysrhythmias per ACLS guidelines
never combine with calcium channel blockers with Dantrolene(can cause increase in hyperkalemia)