Environmental/Toxicology Flashcards

1
Q

A 26-year-old police cadet suddenly collapsed while running in July at the police training camp. You learn that this is only their second day of training and they have been training all day including running, sit-ups, and push-ups. The diagnosis was determined to be acute renal failure. What is the most likely classification for this renal failure?
Intra-renal – vascular
Pre-renal failure
Post-renal failure
Intra-renal – tubular

A

Intar renal tubular
Pre-renal failure would be caused by decreased renal perfusion from a source above the level of the kidneys. Post-renal failure occurs secondary to an obstruction below the level of the kidneys. This patient is suffering from rhabdomyolysis secondary to the intense exertion during high-temperature times. This is an example of a tubular etiology. As myoglobin is released from the breakdown of muscle, it can precipitate in the kidneys leading to renal tubular obstruction and tubular injury. Vascular causes of intra-renal failure would include situations associated with artery obstruction, malignant hypertension, DIC, transplant rejection, etc.

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2
Q

What acid-base imbalances would you anticipate in salicylate toxicity?

Respiratory acidosis and metabolic alkalosis
Respiratory alkalosis and metabolic alkalosis
Respiratory acidosis and metabolic acidosis
Respiratory alkalosis and metabolic acidosis

A

Respiratory alkalosis and metabolic acidosis

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3
Q

A patient in severe hypothermia has an esophageal temperature that reads 28°C. You know that you should withhold cardiac medications until the core temperature reaches what?

28°C
30°C
34°C
32°C

A

30c

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4
Q

You have responded to a fire with five victims. The patients are exhibiting increased signs of respiratory distress and coughing after high-flow oxygen administration. What may be causing these signs and symptoms?

Hydrocarbons
Carbon dioxide
Ammonia
Cyanide

A

Cyanide

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5
Q

Identify the inaccurate statement regarding heatstroke?

Oxygen supply exceeds demand
Level of consciousness is decreased
Core temperature can exceed 104°F
Respiratory alkalosis is a common finding in heatstroke

A

All of the answers are correct except for “oxygen supply exceeds demand.” In the hyperthermic patient, there will be a high demand and low supply. We need to optimize oxygenation through all means necessary.

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6
Q

The electrical activity becomes abnormal when the body core temperature becomes < ______

A

33 degree Celcius

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7
Q

The core temperature starts to show asystole when body core temp is ________

A

19-20 degree

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8
Q

Describe mild hypothermia.

A

Temp between 32-32 (89.6-95)
Shivering
altered judgment
increased RR
increased HH
cold diuresis

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9
Q

Describe moderate hypothermia.

A

28-32 degrees (82.4-98.6)
decreased o2 consumption
stupor
LOSS OF SHIVER!!!!!!!!!!!!!!!
paradoxical undressing
arrhythmia risk

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10
Q

describe severe hypothermia.

A

<28 degree Celsius <82.4 F
V fib
pulmonary edema.
hypotension
no activity on EKG

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11
Q

Thermoregulation

A

Controlled by balance between heat production between heart and liver, and heat dissipation from skin and lungs

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12
Q

Where does temperature regulation occur?

A

Anterior hypothalamus

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13
Q

Describe this 12 lead for a patient that had a long exposure to the cold?

A

The ECG findings of hypothermia include An “Osborne wave” characterized by a notch in the downward portion of the R wave in the QRS complex. Low voltage. Bradycardia: This can be sinus bradycardia, junctional bradycardia, atrial fibrillation with a slow ventricular response, or higher-grade AV blocks

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14
Q

In hydrofluoric acid exposure, you would expect the QT interval to be___________ and the CA++( calcium and MG++ to be _________ due to the hydrofluoric acid rendering them __________. EKG then goes into __________.

A

QT interval > 460 normal QT interval is < 440-460.
Low due to tendering them neutral.
EKG goes into torsades and K+ will be elevated.

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15
Q

Treatment for hydrofluoric?

A

MgSO4 1-2 g
Calcium 500-1000

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16
Q

What type of chemical ingestion is described?
Cell death from disruption of cell membranes, liquefaction necrosis,
injuries occurs immediately
granulation tissue replaces necrotic tissue.
scar tissue can form over 2-4 weeks then form strictures.

A

Alkaline ingestion,
cell death from liquefaction

17
Q

What type of chemical ingestion is this? Cell death from coagulation formation of escar, >4 inches should be evaluated in the ER. usually involves the stomach.

A

Acid ingestion
cell death from coagulation
Think liquefaction for Alkaline ingestion and coagulation from Acid

18
Q

The PH of a product ____________ increases damage

A

<2 or >12

19
Q

What is contraindicated in a caustic ingestion?
What is the treatment for a caustic ingestion?

A

No emetics
No gastric lavage
No activated charcoal

Treatment: control airway, pain management, proton pump inhibitor

20
Q

In Acetaminophen ingestion your patient starts to complain of right upper quadrant pain and tenderness with nausea vomiting tachycardia and hypotension with an increase in AST/ALT levels.

A

Stage 2 toxicity ( 24-72 hours)

21
Q

In Acetaminophen ingestion your patient starts to N/V abdominal pain tender hepatic edge Jaundice,DIC hypoglycemia death of the patient occurs in this stage.

A

Stage 3 (72-96 hours )toxicity

22
Q

In Acetaminophen ingestion your patient has completed resolution of symption and complete resolution of organ failure.

A

Stage 4 (4days-3 weeks )

23
Q

Treatment for Acetaminophen

A

Acetylcysteine (NAC mucomyst ) Acetadote

24
Q

In salicylate ( aspirin ) ingestion your patient begins to hyperventilate what phase is this patient in?

A

Phase 1 remember hyperventilation

25
Q

In salicylate ( aspirin ) ingestion your patient begins with aciduria, respiratory alkalosis potassium loss

A

Phase 2 (12-24) hours

26
Q

In salicylate ( aspirin ) ingestion your patient begins with dehydration, partially compensated metabolic acidosis, hypokalemia

A

Phase 3 (24 hours)

27
Q

Your patient begins with ringing in the ear, NV, vertigo, hyperactivity, depressed DTR, and low-grade fever hallucinations What do you expect?

A

Salicylate ASA toxicity

28
Q

Treatment for ASA toxicity?

A

Ventilatory support, keeping the ventilator rate to the same breath rate as the patient, activated charcoal, maintaining urinary output at 1 ml/kg/hr sodium bicarb 1-2 meq /kg

29
Q

what is the treatment for beta-blocker toxicity?

A

fluids 20ml/kg
Glucagon 5 mg IVP for contractility
Milrinone 300 mcg/kg
pacing
insulin 1 U/KG bolus 1-10 iv infusion

30
Q

Calcium Channel blocker Treatment.

A

Calcium
Insulin
atropine
vasopressors
pacing

31
Q

What are the symptoms of Digitalis Toxicity
what is the therapeutic level?
What are the 2 plants that mimic DIG toxicity?

A

Visual disturbances seeing yellow-green, PVs bradycardia, VT heart blocks
05-2 ng/ml anything out of this range is toxic
Yellow oleander and foxglove

32
Q

Digitalis toxicity produces many EKG arrhythmias. T/F

A

true Digitalis can produce a wide range of EKG arrhythmias.

33
Q

What is the antidote for Digitalis?
and contraindicated medications for Digitalis?

A

Digibind is the antidote
contraindicated meds are procainamide, quinidine, bretylium, calcium chloride, and calcium gluconate

34
Q

What is the cause of Methemoglobinemia? What is the antidote?

A

pain-killing medications benzocaine and lidocaine and the antibiotic dapsone can cause methemoglobinemia after they’re exposed to, nitrites, certain herbicides used in agriculture.

Antidote is Methylene Blue

35
Q

What are the causes and symptoms of organophosphate poisoning?

A

Long exposure to agriculture insecticides. excessive body secretions, including sweat, saliva, mucus, and tears pinpoint pupils

The antidote is Atropine 2-4 mh and 2 PAM

36
Q

What are the cause of Cyanide poisoning.
What is the antidote?

A

Exposure to high levels of cyanide can result in cyanide poisoning, with fire being the most common source of exposure.
The antidote is Amyl nitrate
NA Thio sulfate

37
Q

What are the causes of anticholinergic Toxicity?
what is the antidote ?

A

Some over-the-counter medications like.
cold meds, TCA, antihistimes
The Antidote is: Physostigmine

38
Q

What is the cause of coumadin toxicity?
what is the antidote?

A

Coumadin toxicity occurs when the PTT level is too high. This means that it is taking the blood too long to clot and poses a risk that the patient will suffer a hemorrhage or uncontrolled bleeding.
The antidote is: Vitamin K and FFP

39
Q

What is the antidote for beta blockers:

A

Glucagon and Calcium