ENT disorders Flashcards
What percentage of URIs are viral in nature?
98%
*<2% of URIs are complicated by ABRS
Acute rhinosinusitis definition?
Inflammation of the mucosal lining of nasal passages & paranasal sinuses lasting up to 4 weeks caused by allergens, environmental irritants, and/or infection
Acute bacterial rhinosinusitis (ABRS) definition?
Secondary bacterial infection of paranasal sinuses, usually following viral URIs
Causative pathogens in ABRS (by order rank)?
- S. pneumoniae (gram +)
- H. influenzae (gram - )
- M. catarrhalis (gram - )
S. pneumonia & H. influenzae common causes (Hint: COMPS pneumonic)
Conjunctivitis
Otitis media
Meningititis
Pneumonia
Sinusitis
Majority of antibiotic treatment regimen for ABRS lasts for __ to __ days?
5-7 days
“Double sickening” can be indicative of ABRS (true/false)?
True
*“Double sickening” –> initial symptom improvement and then worsening of symptoms
Fever & symptom duration of more than __ days may be indicative of ABRS?
10 days
True/False: Give the highest dose for shortest amount of time when considering antimicrobial therapy?
True
*Need drug to be able to concentrate med enough to optimize treatment success & minimize development of resistant pathogens
Most common risk factors for antibiotic resistance?
Age <2 or >65 yrs, daycare attendance
Prior systemic antibiotics within PAST MONTH
Hospitalization within past 5 days
Comorbidities
Immunocompromised
Biggest risk with fluroquinolones (ex: -floxacin)?
Tendon rupture
First line treatment for ABRS?
Amoxicillin
or
Amoxicillin-clavulanate (Augmentin)
*may be more effective against ABRS due to H. influenzae & M. catarrhalis coverage
Second line treatment if beta-lactam allergy for ABRS?
If no anaphylaxis hx: Cefdinir, Cefpodoxime, or Cefuroxime
If anaphylaxis history: Levofloxacin, moxifloxacin, or doxycycline (category D pregnancy risk)
Substrate, Inhibitor, or Inducer: A medication that is metabolized/biotransformed by the isoenzyme, utilizing this enzyme in order to be modified so it can reach the drug site of action and/or be eliminated?
Substrate (CYP450)
Ex: Statins, OCP, benzos, sildenafil
Substrate, Inhibitor, or Inducer: A drug or other substance that blocks that activity of the isoenzyme, limiting substrate excretion (increased risk of toxicity)
(hint: doesn’t allow medication to leave the body)
Inhibitor
Ex: grapefruit juice, clarithromycin
clarithromycin + simvastatin = statin-induced rhabdo risk
Substrate, Inhibitor, or Inducer: accelerates the activity of the isoenzyme (pushes med out of body, resulting in decreased effectiveness of med)
(Hint: “jet pack”)
Inducer
Ex: St. John’s wort
St. John’s wort + COC = potential contraceptive failure
What is presbyopia?
Age-related visual change (hardening of lens); near vision is affected (decreased ability to read small print at close range)
What is blepharitis?
Inflammation of the edges of the eyelids where eyelashes grow
Kiesselbach’s plexus location?
Anterior inferior aspect of nose (lower one-third)
Color and appearance of nasal turbinates seen in allergic rhinitis?
Bluish, pale, and/or boggy
White-to-light gray patch that appears on tongue, floor of mouth, inside cheek.
Leukoplakia
Aphthous stomatitis
Canker sore
Geographic tongue
Tongue surface has maplike appearance; benign
Torus palatinus
Painless bony protuberance midline on hard palate; benign
Optic nerve cupping is associated with ____?
Glaucoma
HTN or DM: Copper & silver wire arterioles?
Hypertensive retinopathy
HTN or DM: Arteriovenous nicking
Hypertensive retinopathy
HTN or DM: Cotton-wool spots
Diabetic retinopathy
Clusters of small red papules with white centers inside cheeks by lower molars (Hint: pathognomonic for measles (rubeola)
Koplik’s spots
First line treatment for nasal polyps?
Intranasal glucocorticoids (ex: fluticasone or budesonide BID)
Condition of tongue caused by Epstein-Barr virus (EBV)
Hairy leukoplakia
Excessive constriction of the pupil
Miosis