ENT Flashcards
What are the 3 main chambers of the eye?
- Vitreous chamber
- Anterior chamber
- Cornea to iris
- Filled with aqueous humor
- Aqueous humor drains from anterior chamber thru Schlemm’s canal into venous system
- Posterior chamber
- Iris to lens and ciliary process
What are the 3 layers of the eye globe?
- Sclera (white part)- outermost layer
- Tough, fibrous
- Cornea- visual fx
- Tissue where cornea meets sclera is limbis
- Curvature of cornea is where we have visual power
- Uveal tract- middle
- Choroid- layer of blood vessels- bleeding of choroid can cause expulsive hemorrhage
- Iris- controls light entry (changes size of pupil)
- SNS stim → dilate pupil (iris muscle contracts)
- PSNS stim → myosis (constrict) → pupil constrict (iris sphincter muscle contract)
- Ciliary body- produces aqueous humor
- Retina (innermost layer) – nerve tissue cont. w/ optic nerve . no capillaries. Completely dependent on choroid layer to provide o2 and nourishment to retina
What is the vitreous humor?
Conjunctiva?
Cornea?
Aqueos humor?
Schlemm’s canal?
What is the pupil formed by?
What is a lens?
- Vitreous humor → center of the eye
- Attachment to BV and optic nerve
- Traction to gel → retinal detachment
- Conjunctiva is clear membrane that covers the sclera in the front of the eye.
- Cornea (part of the sclera) is a strong clear bulge located at the front of the eye.
- Aqueous humor is a watery substance located in the anterior chamber of the eye.
-
Schlemm’s canal:
- channel in the eye that collects aqueous humor from the anterior chamber and delivers it into the bloodstream (drainage system)
- Pupil is formed by the iris
- Lens of the eye is a flexible unit that consists of layers of tissue enclosed in a tough capsule
What are the 6 extraocular muscles of the eye?
6 muscles –
- superior rectus
- inferior rectus
- medial rectus
- inferior oblique muscle
- (1-4 innervated by oculomotor nerve- CN III)
- lateral rectus muscle
- innervated by abducens nerve- CNVI.
- superior oblique muscle
- innervated by trochlear nerve- CN IV.
Sit in cone behind eye
All surround optic nerve, artery, vein, ciliary ganglion
Describe the motor innervation of the eye?
-
Cranial Nerve III- Oculomotor
- innervates the superior rectus, medial rectus, inferior rectus, and inferior oblique eye muscles
- Eye movements
- Pupil constriction
- Opens eyelid
- PSNS fibers
- innervates the superior rectus, medial rectus, inferior rectus, and inferior oblique eye muscles
-
Cranial Nerve IV- Trochlear
- innervates the superior oblique muscle
- Moves eye down and outward
- innervates the superior oblique muscle
-
Cranial Nerve VI- Abducens
- innervates the lateral rectus muscle
- Moves eye lateral
- innervates the lateral rectus muscle
Sympathetic fibers from carotid plexus travel through ciliary ganglion → innervate dilator muscles
- Ex: block ciliary ganglion → fixed/dilated pupil
PSNS- CN III
Describe the sensory innervation for the eye.
-
TRIGEMINAL nerve (CN V) – touch/pain
-
Ophthalmic branch (VI): 1st branch
- Innervates the upper eyelid, conjunctiva, and cornea
- Nosociliary branch (of opthalmic nerve)
- sensory to medial canthus, lacrimal sac, and ciliary ganglion
- Ciliary ganglion → provides sensory to cornea, iris, and ciliary body
- sensory to medial canthus, lacrimal sac, and ciliary ganglion
- Also regulates OCR (oculocardiac reflex)
- Nosociliary branch (of opthalmic nerve)
- Innervates the upper eyelid, conjunctiva, and cornea
-
Maxillary branch (V2): 2nd branch of 5
- Innervates lower lids
-
Ophthalmic branch (VI): 1st branch
-
Facial nerve: VII- Exits skull in stylomastoid foramen
- Supplies motor innervation to orbicularis muscle via zygomatic branch
- Ex: block CN VII → cant squeeze lid
- Innervates the lower lid
- Ex: block CN VII → cant squeeze lid
- Supplies motor innervation to orbicularis muscle via zygomatic branch
What is the function of the optic nerve?
- Function:
- Vision
- Carries neural signals from retina
- Part of the optic chiasm (fibrous sheeth)- contains…
- nerve
- artery
- vein
- sympathetic nerves
- Consequences to INJURY → total blindness
What is normal intraocular pressure?
- Normal: ~ 16 mmHg (+/- 5)
-
Abnormal: > 25 mmHg
- Must maintain normal IOP to maintain normal curvature of cornea
- IO perfusion pressure related to CPP
- (MAP – IOP → how eye regulates perfusion)
- Ex: High IOP → impairs BF to optic nerve (fx effected)
How is aqueous humor produced?
- Posterior chamber:
- 2/3 produced by ciliary body (~80-90%)
- → then actively moved from posterior chamber to anterior chamber by an active sodium pump mechanism.
- Active Na pump (AKA → Na-K ATPase carbonic anahydrase enzyme)
- Passive filtration: 1/3 (~20%)
- comes from passive filtration through vessels in iris. across ciliary epithelium
- Aqueous fluid is produced at a rate of 2 uL/min.
How is aqueous humor eliminated?
- Fluid drains out of eye through trabecular meshwork (spongy tissue) → - into canal of Schlemm’s and the episcleral venous system (in anterior chamber) → eventually ending up at SVC and RA.
- Drainage system
- Trabecular meshwork → eventually go back into central circulation
- Anything affecting flow → cause increase IOP
- Drainage system
What can happen if elimination of aqueous humor is impaired?
- Open angle glaucoma (OAG): Sclerosis of trabecular meshwork
- chronic elevation
- Closed angle glaucoma (CAG): Obstruction of Aqueous drainage from closure of anterior chamber angle
- CAG Causes:
- Iris swelling
- Anterior displacement
- CAG Causes:
- Pts already w/ narrow angle predisposed to acute increase IOP (PAIN & emergency)
What determines intraocular pressure?
- A measurement of the fluid pressure inside eye
- The globe is a relatively noncompliant compartment and the volume of the internal structures is fixed, except for aqueous fluid and choroidal blood volume.
- The quantity of these two factors regulates intraocular pressure.
- The globe is a relatively noncompliant compartment and the volume of the internal structures is fixed, except for aqueous fluid and choroidal blood volume.
-
Determined by:
- Production of aqueous humor
- Drainage of aqueous humor
- Changes in choroidal blood volume or pressure
- Extraocular muscle tone
- Normal IOP: 10-20 mmHg (~ 16 and +/- 5)
- >25 mmHg, you have problem
What increases IOP?
- Drugs:
- Ketamine (?) → theoretically causes issues but does not directly
- Succinylcholine (increases by 8-10 mmHg)
- d/t
- decrease in Aqueous humor outflow
- increase in choroidal BV
- increase in CVP
- d/t
- Other:
- MOST SIG INCREASE → Laryngoscopy & Emergence
- Sympathetic Blunting
- Less manipulation of AW the better (LMA less increase than DL)
- Position changes
- Coughing, valsalva maneuver, straining, vomiting, HTN, injection of local anesthesia, laryngoscopy, hypercarbia/hypoventilation/ hypoxia, lid pressure, eye compression, forceful lid squeeze (increases to 70 mmHg), pupil mydriasis (dilation)
- Increases up to 30-40 mmHg
- MOST SIG INCREASE → Laryngoscopy & Emergence
What can decrease IOP?
- Drugs:
- Most anesthetic drugs:
- VA (excluding N2O → no effect)
- Propofol
- Etomidate
- Opioids
- NDMR
- hypertonic solutions
- Dextran
- Mannitol
- Most anesthetic drugs:
- Other: Hypotension, hypothermia, hyperventilation, pupil miosis (constriction)
What are some anesthetics that have no effect on IOP?
- N2O
- Versed
- ~NDNMB
What is acetazolamide?
MOA, S/E?
Carbonic anhydrase inhibitor (topical for eye)- brand Diamox
- Treatment for glaucoma
- Induces:
- decreases IOP*
- diuresis
- reduces aqueous humor production
-
K+ depletion (+/-)
- want preop labs
- SE:
- Confusion
- Drowsiness
- Low K
- Low Na
- Acidosis
- Polyuria
What is echothiophate?
- Tx for glaucoma
- Irreversible cholinesterase inhibitor
- Produces:
- miosis
- Produces:
- Systemic absorption may cause total body inhibition of plasma cholinesterase
-
CAUTION:
- Prolong effects of:
- Succinylcholine
- Mivacuronium
- Toxicity w/ Ester LAs
- Prolong effects of:
-
Very long DOA:
- Need to stop 4-6 weeks preoperatively
-
CAUTION:
Why is it important to know eye drops pt is on?
**Nasal mucosa/conjunctival capillaries connected to eyes → causing systemic absorption
-
Systemic effects worse in: (greater toxicity risk)
- Children
- Elderly
- Preop: Know what drops pt on
Phenylephrine eye drops? s/e?
- Produces mydriasis
- Associated w/:
- severe HTN
- Arrythmias
- Adverse CV events
- Very high [] (1 drop = 5 mg)
What are clycloplegics?
Atropine and Cyclopentolate
- Pupil mydriasis (dilation)
- Systemically absorbed
- SE: See anticholinergic symptoms
- Dry mouth
- Dry skin
- Fever
- Agitation
- disorientation, psychotic reactions
- Central anticholinergic symptoms
- SE: See anticholinergic symptoms
Effect of acetylcholine in eye drops?
- Produces miosis
- Cholinergic agonist
- Causes:
- Bradycardia
- acute bronchospasm
- hypotension
What is timolol?
- Tx of glaucoma
- B1/2 antagonist
- Produces:
- Miosis
- reduction of aqueous humor production
- SE:
- Bradycardia
- Bronchospasm
- CHF exacerbation
- heart block
- Issues w/ nursing infants
NSAID use in eye drops?
- Ketorolac and Diclofenac
- Used for inflammation
Scopalamine effect on eyes?
- Mydriasis (dilation)
- Can causes central anticholinergic syndrome
What is the oculocardiac reflex?
Aka Trigeminal-vagal reflex
- Reflex triggered:
- → pressure on globe, pain, and / or traction on extraocular muscles, retrobulbar block, orbital injections, trauma, and hypoventilation (hypercarbia and hypoxemia)
- Ex: *traction on medial rectus muscle
- Pressure on periosteum
-
Afferent limb arises from ophthalmic division of trigeminal nerve → goes to gasserian ganglion and sensory nucleus of trigeminal nerve near the 4th ventricle
-
Afferent limb synapses with motor nucleus of vagus nerve → efferent impulse that travels to heart (via vagus nerve) → leads to:
- Decreases HR
- Decrease contractility
-
Afferent limb synapses with motor nucleus of vagus nerve → efferent impulse that travels to heart (via vagus nerve) → leads to:
- → pressure on globe, pain, and / or traction on extraocular muscles, retrobulbar block, orbital injections, trauma, and hypoventilation (hypercarbia and hypoxemia)
What is the oculocardiac reflex associated with?
- Bradycardia
- atrioventricular block
- ventricular ectopy
- negative inotropy
- asystole
- Occurs most often during strabismus surgery (peds pts)
- Pulling/traction of medial rectus muscle
- May be seen more often under topical anesthesia
- Occurs most often during strabismus surgery (peds pts)
How can you reduce the occurrence of the OCR?
- Maintain normal ETCO2, SpO2
- Pretreat with anticholinergic
- (atropine or glycopyrrolate)→ have ready
- Considerations:
- *Pts typically elderly (increasing HR decreases coronary perfusion pressures)
Treatment of OCR?
- Stop stimulus
- Assess ventilation:
- Correct hypoxia/hypercapnia (can worsen reflex)
- Admin: 100% FiO2
- normal ETCO2? SpO2?
- Correct hypoxia/hypercapnia (can worsen reflex)
- Deepen patient
- Atropine 7 ug/kg increments or Glycopyrolate
- Worsen → Epi
- Local anesthetic (lidocaine) into muscle
Preop assessment of ophthalmic patient?
- High risk population/low risk surgery
- Elderly, co-morbidities
- These Pts cannot typically have outpt sx:
- Severe cardiomyopathy, pulmHTN
- Home O2
- Super morbid obese
- Known DAW
- OK to do just 1 mg Midaz
- Chronic conditions that may make it difficult to lie still and /or supine
- SOB, chronic cough, nasal drip, reflux, nausea
- Parkinson’s, Alzheimer’s or claustrophobia, mentally disabled, back pain, OSA
- These Pts cannot typically have outpt sx:
- Pediatric patient cooperation
- Non-english speaking, deaf
- Might have to consider more than MAC case
- EKG not indicated per AHA/ACC
- NEED to educate pt on what to expect. pt needs to stay still, will have blue drape over face
- 30% of eye injury during ophthalmic surgery with anesthesia were related to patients moving.
- Blindness was the outcome in all cases!
- Most problems occurred under GA, 25% under MAC.
- **Ensuring pt immobility during the procedure are therefore of the utmost importance
Preparation for ophthalmic sx?
- Pre-operative ophthalmic drops
- Continue home medication regimens
- Education of being awake/still during surgery (what to expect)
- Blue drape over face
- Wont be able to see
- Duration
- Avoid over-hydration
- Control HTN
- Control BS
- No steroid coverage needed
- Dry secretions
- Sniffing/coughing → causes movement
- Treat reflux
- Good intraoperative positioning
-
Preop:
- Preexisting anticoagulants
- weigh risks vs benefits (talk to surgeon)
- don’t have to stop anticoag necessarily
- Preexisting anticoagulants
- ASA Recommendations:
- ASA 1 or 2: No routine preop lab testing before cataracts sx
- EKG done based on pt hx
- considered low risk sx
-
Preop:
What types of anesthesia are used for eye surgery?
What is goal of anesthesia for eye surgery?
- *Regional Anesthesia
- *Topical Anesthesia
- Sedation
- Adjunct w/ topical
- General Anesthesia
Goals:
- safety, akinesia (immobility of eye), analgesia
- minimal bleeding
- avoidance or obtundation of the oculocardiac reflex
- prevention of increased IOP
- awareness of drug interactions (drops)
- smooth emergence devoid of vomiting, coughing, or retching.
How do you perform a retrobulbar block?
- Retract the eye lid and insert the needle (3-cm, 23-25 gauge blunt needle) thru temporal aspect of lower lid (below the globe)
- direct needle perpendicular (bevel up) to the plane of face toward the orbital apex with sufficient depth and angulations that the cone is penetrated.
- At junction of inferior and lateral walls of orbit
- Inferior to orbital rim
- Aspirate. LA instilled posterior to the eye.
- Usually equal amounts of lidocaine 2% and bupivicaine 0.75% without epinephrine (@ 2-3 ml).
- Hyaluronidase is added to speed tissue penetration. Place gentle pressure on the eye for about 5 minutes to increase spread of LA (or use Honan cuff compression balloon).
- Onset around 5-10 minutes
- → see “down gaze”
Setup for retrobulbar block? Meds used?
- Routine monitoring
- Position:
- Supine
- HOB 10-15 degrees up
- Oxygen by nasal cannula
- Sedation
- Propofol in small increments (20mg) but no analgesia, pt may startle upon needle insertion
- Remifentanil (0.3-0.5ug/kg) lasts 2-5 minutes while the block is going in.
- Caution w/ Midazolam, can be added depending on pt age.
- Infusions are NOT necessary; you want the pt to remain aware and unobtunded during surgical procedure
- LA instilled by injection posterior to eye directly into the orbital cone
- 2% lidocaine/0.75% bupivicaine 1:1 ratio, 2-3 ml
- Hyaluronidase added for tissue penetration
- Excellent akinesia and analgesia
Complications of retrobulbar block?
-
Retrobulbar hemorrhage - most common* - ~1% cases
- Venous hemorrhage – not as bad
- Arterial hemorrhage → swelling, proptosis (eye bulge out), immobility of globe
- Compressive hematoma → vision loss!
- Intraarterial injection → Seizures!
- LA pass from ophthalmic a. to internal carotid → thalamus and midbranch structures
- ASPIRATE
- LA pass from ophthalmic a. to internal carotid → thalamus and midbranch structures
- Globe perforation
- Optic nerve damage
- OCR
- Seizures
- Resp arrest
- **Partial/total brainstem anesthesia
- Aphagia
- Confusion
- Apnea
- CV arrest
- Szs
- Supportive tx → resolve in few hrs**
Technique for peribulbar block?
- 23 G blunt needle inserted thru skin and advanced along the orbit floor directed parallel to the globe (thru the lower lid) toward the sphenoid bone.
- “Needle introduced outside cone” →
- NO risk of retrobulbar hem
- Decrease risk of optic N injury
- “Needle introduced outside cone” →
- LA instilled into extraconal space (outside the muscle cone) and will slowly penetrate toward the optic nerve.
- Two separate injections:
- Inferior/Temporal
- Superior/Nasal
- Two separate injections:
COnsiderations for peribulbar block?
- Safer
- C/t retrobulbar block bc muscle cone not penetrated (into extraconal space)
- Slower onset of action
- 10 min vs 5 min
- Higher volumes of LA
- Ex: 5- 10 ml (c/t 2-3 ml)
- Lower incidence of complete eye akinesia
-
Complications:
- Globe perforation
- Failure of block
Technique and complications of sub-tenon block?
- Anesthetic drops applied
- Using blunt cannula →
- LA injected (1-3 ml) under Tenon’s fascia
- Uses:
- Excellent analgesia for iris & anterior eye
-
Complications:
- conjunctival edema
- Technique:
- topical drops applied to anesthetize surface
- speculum is placed to retract lids → have pt look out and up → take iris scissors to “nick” in conjunctiva/ or use cautery while a curved blunt ophthalmic needle (cannula) is directed toward outer edge of globe into a Bare Sclera
- Bare sclera: a potential space under Tenon’s fascia posteriorly
- Needle is inserted 1.7 cm depth [1-3cc can be inserted depending on size of globe].
- Then LA in injected into space.
What is the purpose of a facial nerve block in eye surgery? Complications?
- Anesthesia to eyelids
- Keeps orbicularis muscle still
- Ex: prevent increases in IOP from squeezing lid
- Keeps orbicularis muscle still
-
Complications:
- facial droop
- vocal cord paralysis
- respiratory distress
- Block technique: local infiltration field block CNVII as it exits stylomastoid foramen or at level of orbicularis oculi muscle or at condyle of the mandible.
How is topical anesthesia provided for eye surgery?
Considerations? Disadvantages?
- Instillation of LA solution onto eye
- Ex: Proparacaine, Tetracaine, Lidocaine
- Anesthetized locations: (2)
- Cornea
- Conjunctiva
- Ex: if req total akinesia of eye → topical wont be ok
- Considerations:
- Hyaluronidase adjunct
- Speeds up tissue penetration
- Sedation +/-
- Want cooperative but still patient
- Hyaluronidase adjunct
-
Disadvantage:
- potential eye movement
- increased patient anxiety
- discomfort
Technique for sedation for eye surgery?
-
Technique:
- All standard monitors on
- Supplemental oxygen by NC
- Blend w/ air if using cautery
- Positioned for comfort
- Meds: Mild/Mod sedation
- Propofol bolus @ 0.5 mg/kg for block placement only
- Midazolam 0.5-1 mg and/or Fentanyl 12.5-50 mcg
- Ex: cataract sx- just topical LA needed
- Avoid CO2 build-up under drapes
- also avoid O2 buildup- use suction
- Additional info:
- 60-70% ophthalmic sx: combo of block & MAC
- MAC:
- Less hypotension
- Faster recovery
- Less PONV
- MAC:
- 60-70% ophthalmic sx: combo of block & MAC
Other drug options
- Precedex, slower onset, nut used normally
- Ketamine causes too much dysphoria, esp in elderly
- Just need propofol when giving the actual block
Induction considerations for general anesthesia for eye surgery?
- Smooth intubation
- LMA ok
- Avoid: meds increasing IOP
- Ketamine
- succinylcholine
- Blunt responses to airway maneuvers/avoid pressure on eye
- Avoid N2O
- Ex: bc injection of gases (sulfahexafluride, octofluropropane) to cause retinal tamponade
- Avoid N2O use for 3-8 wks
- Ex: bc injection of gases (sulfahexafluride, octofluropropane) to cause retinal tamponade
Maintenance considerations for general anesthesia for eye procedures?
-
Avoid:
- Hypoventilation/ may want mild hyperventilation
- Ex: acidosis → increases IOP
- HTN (treat)
- bucking or moving
- direct pressure on eye
- Hypoventilation/ may want mild hyperventilation
- Typically not a very stimulating procedure once eye topicalized, may need lower anesthetic during case.
Emergence and postoperative considerations for general anesthesia for eye procedures?
Goals for general anesthesia for eye procedures?
-
Emergence
- Smooth wake up
- Prevent coughing, bucking, vomiting
- Ex: Propofol, IV lidocaine, deep extubation
- Prevent coughing, bucking, vomiting
- Pretreat w/ antiemetics
- Smooth wake up
-
Post-operative
- Treat PONV
- 2fold- some risky for increase N/V (like strabismus sx) and increase IOP
- Good pain control
- Treat PONV
Goals: smooth induction, stable IOP, avoid OCR, motionless field, smooth emergence, NO N/V, No postop pain
- 30% cases req GA
- Peds
- Adults w/ cog impariement
- Watch fluids
What is open angle glaucoma?
- Sclerosis of trabecular tissue → causing increase IOP → affecting vision
- develops slowly and bilaterally
-
-Treatment:— frequently just treated by meds, more chronic process
- Miosis
- decrease production of aqueous humor
- trabecular stretching
What is closed-angle glaucoma?
- Peripheral iris moves into direct contact with corneal → mechanically obstructing aqueous flow
- acute process, more rare
-
Treatment:
- Immediate surgery
- Glaucoma is characterized by an increase in IOP to the point where blood flow is compromised (diminished capillary blood flow to the optic nerve) and the optic disc is compressed, which will eventually lead to blindness
- Immediate surgery
- Avoid elevation in IOP
Anesthesia management for glaucoma surgery?
- Surgeries performed:
- Laser trabeculoplasty
- Trabeculectomy
- Tube-shunt surgery
-
Anesthetic Management
- Continue medical management to maintain miosis
- Limit the use of anticholinergics (cause dilation)
- Avoid increases in IOP
- If severe acute glaucoma attack- dry pale painful eye:
- treat w/ Mannitol or Acetazolamide