ENT Flashcards
What kind of receptor are taste/smell receptors?
Chemoreceptors
Where are taste receptors located?
Tongue, palate, epiglottis and pharynx
What is the lifespan of a receptor cell?
approx. 10 days
What are the four types of papilla on the tongue?
Filiform, fungiform, vallate and foliate
Which type of papilla does not contain tastebuds?
Filiform
What are “tastants”?
Taste provoking chemicals
What happens when tastants bind to taste buds?
Ionic channels change to produce a depolarising receptor potential which initiates APs in afferent nerves
Signals conveyed to brainstem and thalamus then to cortical gustatory areas in the frontal lobe
What nerve gives supply to the epiglottis and pharynx?
CNX, vagus
What are the five primary tastes?
Salty, sour, sweet, bitter, umami
What stimulates salty taste receptors?
Chemical salts, especially NaCl
What stimulates sour taste receptors?
Acids with free H+ ions
What stimulates sweet taste receptors?
Glucose
What stimulates bitter taste buds?
Alkaloids, poison and toxic plant derivatives
What stimulates umami taste buds?
Amino acids, especially glutamate
What is ageusia?
Loss of taste
What is hypoguesia?
Reduced taste function
What is dysguesia?
Distortion of taste
What can cause aguesia?
Nerve damage, inflammation, endocrine disorders
What can cause hypogeusia?
Medication or chemo
What can cause dysguesia? (9)
Glossitis, gum infection, tooth decay, reflux, URTIs, medication, cancer, zinc, chemo
Which cell types does olfactory mucosa contain?
Olfactory mucosa, supporting cells and basal cells
Describe the structure of an olfactory receptor.
Thick short dendrite with a wide end called an olfactory bulb from which there is cilia projections
What is the lifespan of an olfactory receptor?
2 months
Describe the path of a signal from the olfactory nerve to the brain.
Olfactory receptors which then form afferent fibres of the olfactory nerve which pierces the cribiform plate to enter olfactory bulbs in the inferior surface of the brain then along the olfactory tract to reach the temporal lobe and olfactory areas.
How do odorants reach receptors in quiet breathing?
Diffusion
What must a substance be in order to be smelled?
Volatile to be inspired with air
Soluble in water to dissolve in the mucous
What is anosmia?
Inability to smell
What can cause anosmia?
Viral infection, allergy, nasal polyps, head injury
What is hyposmia?
Reduced ability to smell
What is dysosmia?
Altered sense of smell
At which frequencies do humans perceive sound?
20-20,000Hz
Summarise the main role of the outer ear
Sound collector
Summarise the main role of the middle ear
Mechanical force amplifier
Summarise the main role of the inner ear
Sound transducer
What is the TM to OW ratio?
18:1
Where are sound waves transmitted to after the OW?
Cochlea, organ of Corti on basilar membrane
Which nerve is stimulated on depolarisation of the Organ of Corti?
CN VII, vestibulocochlear (then to central pathways)
In the rest state is the Eustachian tube opened or closed?
Closed
Which muscles can open the Eustachian tube?
Tensor veli palatine and levator palatine
Why does the Eustachian tube open?
To equalise pressure in the ear
What is the scala media?
Cavity inside cochlea, between the tympanic duct and the vestibular duct, separated by the basilar membrane and Reissner’s membrane
What does the scala media contain?
Endolymph and Organ of Corti
What do the scala tympani and the scala vestibule contain?
Perilymph
When do the hair cells on the cochlea depolarise?
When hairs are deflected towards the longest hair
What are the five vestibular end organs?
Ampullae of lateral, posterior and superior semi-circular canals
Maculae of utricle and saccule
What process does the brain perceive as movement?
Weight of the gelatinous matrix changing
This is where the stereocilia/hairs of the utricle and sacuule project
What are otoconia?
Calcium carbonate crystals
Where at otoconia found?
Utricle and saccule
What do otoconia do?
Sense linear movement and gravitational movement
What happens to otoconia on movement?
They exert a shearing force on the hair they are coupled to
How are signals transmitted from the utricle and saccule?
Utricle - superior division of vestibular nerve
Saccule - inferior division of the vestibular nerve
Why are throat swabs not routinely carried out?
Due to commensals which are not the causative organism
When would you considering referring sore throat?
If neck mass present or if lasts longer than 3-4 weeks
When would you considering referring dysphagia or odynophagia?
If progressive or lasting >3 weeks
What supportive advice would you give a sore throat?
Avoid hot drinks, good fluid intake, warm salty water washes
What are the points on the Centor criteria?
Tonsillar exudate; cervical lymphadenopathy; fever; no cough
Who can’t the Centor criteria be used for?
Children under 3
What is the most common bacterial cause of sore throat?
Strep pyogenes
What is strep pyogenes?
Gram positive cocci, beta haemolytic
Which conditions may occur following a sore throat?
Rhuematic fever 3 weeks post sore throat
Glomerulonephritis 1-3 weeks post sore throat
How does diphtheria present?
Severe sore throat with a white membrane across the pharynx
Which bacteria causes diphtheria?
Corynebacterium diptheriae
When is the toxoid vaccine for diphtheria given?
2, 3 and 4 months
How is diphtheria treated?
Anti-toxin, penicillin/erythromycin and supportive treatment
What causes oral thrush?
Candida albicans
How does oral thrush present?
Patches of red raw mucous membranes in the throat and mouth
How is oral thrush treated?
Nystatin
Which group most commonly gets acute otitis media?
Children and infants
How does acute otitis media present?
Discharge, hearing loss, fever, lethargy
Which bacteria commonly cause acute otitis media?
H influenzae
Strep pyogenes
When do you take a swab in acute otitis media?
If the TM perforates, but not unless that happens
How should acute otitis media be treated?
Most resolve within 4 days without abx
If not, give amoxicillin or erythromycin
If immunocompromised, systemic illness or bilateral AND under two, give abx immediately
How does acute sinusitis present if there is secondary bacterial infection?
Severe pain and tenderness with purulent nasal discharge
What usually predisposes acute sinusitis?
URTI
How is acute sinusitis treated?
If severe/deteriorating for >10 days, penicillin or doxycycline
Most are self limiting over 2.5 weeks
What is otitis externa?
Infection of the outer ear canal
How does otitis externa present?
Swelling and redness of the ear canal, itch, pain, discharge
What are bacterial causes of otitis externa?
Staph aureus, pseudomonas aeruginosa
What are fungal causes of otitis externa?
Aspergillus niger, candida albicans
How is bacterial otitis externa treated?
Topical aural toilet
How is fungal otitis externa treated?
Topical clotrimazole (canesten) or gentamicin 0.3% drops
What is malignant otitis externa?
Extension of otitis externa into the surrounding ear canal
Which bones does malignant otitis externa commonly affect?
Mastoid and temporal
How does malignant otitis externa present?
Disproportionately severe pain and headache; exposed bone in ear canal and facial nerve palsy
How is malignant otitis externa investigated?
PV, CRP, imaging, biopsy and culture
What is a culture in malignant otitis externa most likely to show?
Pseudomonas aerginuosa
Which patients are at risk of malignant otitis externa?
Immunocompromised and radiation to head and neck
Which virus causes infectious mononucelosis?
EBV
How does infectious mononucleosis present?
Fever, lymphadenopathy, sore throat, pharyngitis, tonsillitis, malaise, lethargy, jaundice, rash, atypical lymphocytes
How is infectious mononucleosis treated?
Usually self-limiting over 4 weeks, paracetamol
Corticosteroids if it is a complicated case
What advice should be given to infectious mononucleosis patients?
Avoid sport for 6 weeks (to avoid splenic rupture); get bed rest; avoid alcohol
How is infectious mononucleosis investigated?
EBV IgM; Paul Bunnell test; FBC; LFT; monospot film
When is HSV Type 1 most likely to be acquired?
In childhood, through saliva contact
What are the symptoms of HSV type 1?
May be asymptomatic OR systemic upset, fever, inflammation, vesicles on lips, buccal mucosa and hard palate
How is HSV type 1 treated?
Acyclovir 3 weeks
Which type of HSV tends to reactivate more?
HSV Type 2
Which virus causes genital herpes?
HSV Type 1 or 2
What is a herpetic whitlow?
Paiful lesion on finger or thumb caused by HSV
How is HSV confirmed?
Swab of whitlow lesion and PCR