ENT Flashcards

1
Q

management of allergic rhinitis?

A

nasal antihistamine is first line

others:
oral antihistamine for sneezing
intranasal corticosteroid for nasal blockage
sodium cromogliate can be used as an add on

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2
Q

example of an intranasal antihistamines?

A

azelastine

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3
Q

what do intranasal antihistamines (azelastine) interact with?

A

MAOi

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4
Q

contraindications to cetirizine?

A

acute porphyrias
be careful in epilepsy

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5
Q

SE and risks of cetirizine?

A

antimuscarinic - blurred vision/dry moth/urinary retention
GI disturbance
headache
angle closure glaucoma
arrhythmias
blood disorders
convulsions
EPS
liver dysfunction
hypersensitivity reactions

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6
Q

2 examples of oral antihistamines used for allergic rhinitis?

A

cetirizine
loratidine

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7
Q

when is fluticasone contraindicated/

A

after nasal surgery
in TB
in untreated nasal infections

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8
Q

what can fluticasone interact with?

A

live vaccines
NSAIDs
clarithromycin

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9
Q

examples of nasal corticosteroids used in allergic rhinitis?

A

beclometasone
fluticasone

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10
Q

SE of fluticasone?

A

raised IOP
headache
nasal septal perf
nasal irritation
throat irritation/taste distruabnce
hypersensitivity reactions
psychological effects in children

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11
Q

MOA of sodium cromoglicate?

A

mast cell stabiliser

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12
Q

SE of sodium cromoglicate?

A

transient bronchospasm
local irritation

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13
Q

what can be used in Menieres disease to help alleviate nausea and vertigo?

A

prochlorperazine or an antihistamine like cinnarizine

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14
Q

what can be given to help prevent recurrent attacks of Menieres disease?

A

betahistine

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15
Q

moa of prochlorperazine?

A

dopamine receptor antagonist - acts centrally on CTZ

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16
Q

contraindcatins to prochlorperazine?

A

phaeochromocytoma
cautions in elderly, Parkinsons, CVD, diabetes
pregnancy and breastfeeding

17
Q

SE of prochlorperazine?

A

EPS - Parkinsonisms, akathisia, tadive dyskinesia, dystonia
hyperprolactinaemia and hyperglycaemia
arrhythmias
VTE
leucopenia/agranulocytosis
blurry vision, dry mouth, drowsy, urinary retention

18
Q

what does prochlorperazine interact with?

A

alcohol
anti-muscarinics
levodopa
antihypertensives
CNS depressants
MAOi
lithium

19
Q

moa of betahistine?

A

histamine analogue - H1 agonist
thought to improve microcirculation and reduce endoplymphatic pressure

20
Q

CI for betahistine?

A

phaeochromocytoma
caution with asthma and PUD

21
Q

SE of betahistine?

A

GI distruabnce
headaches
pruritus
rash

22
Q

what does betahistine interact with?

A

antihistamines

23
Q

what 4 drug groups can cause tinnitus?

A

Aspirin/NSAIDs
Aminoglycosides
Loop diuretics
quinine

24
Q

what 3 drugs can cause gingival hyperplasia?

A

phenytoin
ciclosporin
CCB