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NEUROPATOLOGÍA > Enfermedad de Alzheimer > Flashcards

Enfermedad de Alzheimer Flashcards

1
Q

Con que esta asociado el Alzheimer ?

A

a trisomía 21. (Sx. Down)
Asociado con otras enfermedades neurodegenerativas.

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2
Q

Cambios anatomopatológicos

A

Atrofia cortical es el dato macroscópico característico.
Predominan el lóbulo temporal y frontal.

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3
Q

Estadio A

A

Baja densidad de placas. Corteza frontal y temporal.

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4
Q

Estadio B

A

Placas presentes en corteza de asociación. Hipocampo

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5
Q

Estadio C

A

Placas presentes en cortezas primarias.

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6
Q

Estadio temprano

A

Acumulación de tau (detectable por inmunohistoquímica).

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7
Q

Estadio medio

A

Tau se acumula en filamentos helicoidales. Observable con microscopía.

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8
Q

Estadio tardío

A

Muerte neuronal. Se queda proteína tau, hay depósito de b-amiloide e inflamación.

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9
Q

La Sintomatología Cursa por 3 etapas , cuales son ?

A

Asintomático
Pre-demencia: Deterioro cognitivo leve.
Demencia.

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10
Q

Cual es el signo más importante ?

A

la falla de memoria

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NEUROPATOLOGÍA (22 decks)

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