Energy and nutrition Flashcards

0
Q

What makes up the basal metabolic rate?

A
  • Maintains resting activity of the body
  • Function of organd
  • Body temperature
  • Cell metabolism (biosynthesis, growth, transport, activity etc)
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1
Q

What three things accounts for daily energy expenditure?

A
  • Basal Metabolic Rate
  • Voluntary physical activity
  • Processing consumed food
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2
Q

List the essential components of the diet

A
  • Vitamins and Minerals
  • Water
  • Fibre -> essential for normal bowel function
  • Essential a’a, vital in biosynthesis (source of N/precursor of hormones)
  • Fats, necessary to absorb vit A,D,E,K. Some FA are structural components of membranes
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3
Q

What are the clinical symptoms of marasmus and to whom does it usually occur?

A
  • Children emmaciated
  • Muscle wastage
  • Loss of body fat
  • No oedema
  • Hair is dry and thin
  • Anaemia
  • Diarrhoea
  • Young children who receive no food source
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4
Q

Why is hair dry and thin in marasmus?

A

-No fats so cannot absorb fat soluble vitamins

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5
Q

Why is there muscle wastage in marasmus?

A
  • All energy stores have been depleted
  • No source of food
  • Muscles undergo proteolysis for gluconeogenesis for a source of energy as no fat stores
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6
Q

Why is oedema not seen in marasmus?

A
  • Proteolysis means there is a protein metabolism
  • Protein levels not reduced in the blood
  • Colloid oncotic pressure normal
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7
Q

What are the clinical signs of kwashiorkor and to whom does it happen?

A
  • Generalised Oedema
  • Distended abdomen
  • Anaemia
  • apathetic, lethargic and anorexic (loss of appetite)
  • Children who are often displaced from breast feeding which is replaced by carbs
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8
Q

Why is the abdomen distended in kwashiorkor?

A
  • Due to hepatomegaly and/or ascites
  • Hepatomegaly due to fatty liver
  • Fatty liver due to fat mobilisation (receiving carbohydrates)
  • Fat stored in liver as no lipoproteins
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9
Q

Why are there no lipoproteins in kwashiorkor?

A

No lipoproteins as there is no protein metabolism

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10
Q

Why is there no muscle wastage in kwashiorkor?

A
  • Children receiving carbohydrates
  • Carbohydrates stimulate insulin production which stops proteolysis
  • Muscles do not undergo proteolysis
  • No protein metabolism present
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11
Q

Why is oedema seen in kwashiorkor?

A
  • No protein metabolism as children receiving carbohydrate
  • leads to hypoalbuminaemia (low serum albumin in blood)
  • this causes a reduction in colloid oncontic pressure
  • low oncontic pressure means that water is not reabsorbed from the interstitial space at the venous end of the blood vessel
  • Therefore there is excess tissue fluid in the interstitial space (oedema)
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12
Q

When does obesity occur?

A
  • When there is an imbalance between energy intake and energy expenditure
  • affected by long term food choices and lifestyle
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13
Q

How do you calculate BMI?

A

-Weight (kg)/Height(m2)

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14
Q

List comorbidities of obesity

A
  • Stroke
  • Heart Disease
  • Hypertension
  • Diabetes
  • Certain Cancers
  • Osteoarthritis
  • Hyperlipidaemia (associated with greater upper proportion of body fat)
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15
Q

Define Homeostasis

A

The control of the internal environment within set limits and is a dynamic equilibrium rather than a steady state

16
Q

How does homeostasis work? Name examples

A
  • Through feedback loops (generally negative)
  • Thermoregulation
  • Cellular Ca concentration
  • ATP production (ADP activates glycolysis/ATP ingibits glycolysis)
17
Q

Define Exergonic reaction

A

A reaction which releases more energy than it uses

18
Q

Define Endergonic reaction

A

A reaction which uses more energy than it releases

19
Q

What are the main cell nutrients?

A
  • Glucose
  • a’a
  • TAGs
  • FAs
  • Cholesterol
20
Q

Define cell metabolism

A

-Highly integrated network of chemical reactions made of disting metabolic pathways

21
Q

What are the main functions of cell metabolism?

A
  • Provide ATP
  • Provide building blocks for biosynthesis
  • Provide reducing power
  • Provide organic precursor molecules (AcetylCoA)
22
Q

Describe catabolism

A
  • Break down of larger molecules into smaller ones
  • Ultimately provides ATP
  • Produces intermediates
  • Usually oxidative
23
Q

Describe Anabolism

A
  • Synthesises larger molecules from smaller ones
  • Requires energy which is provided from catabolism
  • Usually reductive
24
Q

What is oxidation?

A
  • Addition of oxygen

- Removal of Hydrogen

25
Q

What is reduction?

A

-Addition of hydrogen

26
Q

Where are NAD+, NADP+ and FAD+ derived from?

A

-The diet; vitamins niacin and riboflavin

27
Q

Are NAD, NADP and FAD levels constant within a cell?

A

Yes, they cycle between an oxidised and reduced state

28
Q

Why is creatine phosphate useful in skeletal and cardiac muscles?

A
  • Small store of free energy as it has a high free energy of hydrolysis
  • Useful in a few seconds of vigorous exercise
29
Q

How is creatinine produced and how is it used in a clinical setting?

A
  • Non-enzymatic conversion of creatine phosphate and creatine
  • Has no bodily function so is excreted via urine
  • High levels of excretion of creatinine is an indicator of muscle wastage
  • Low levels of creatinine can indicate renal failure