Endometrial Conditions Flashcards
What is adenomyosis?
Endometrial tissue in the myometrium
Management of adenomyosis
GnRH agonists
Hysterectomy
What are polyps? What is the pre-cancerous progression?
Benign growths
Pre-cancerous = endometrial hyperplasia
Presentation of polyps
Asymptomatic
Abnormal bleeding
Causes of endometritis
Infection (neisseria, chlamydia)
Postpartum
IUD
What endometritis is associated with PID?
Chronic plasmacytic endometritis
Management of PID
IM Ceftriaxone
100mg Doxycycline BD
400mg Metronidazole BD
Management of Postpartum Endometritis
Clindamycin
Gentamicin
What are fibroids?
Benign tumour of uterine smooth muscle
Presentation of Fibroids
Asymptomatic
Menorrhagia
Infertility
Mass Effect
Investigation of Fibroids
USS
Bloods
Management of Fibroids
IUS
Menorrhagia management
Surgical options
What is endometriosis? Common sites?
Endometrial tissue in the wrong place
SITE = ovaries, Pouch of Douglas, peritoneum
Presentation of Endometriosis
Severe dysmenorrhoea
Pre-menstrual pain
Dyspareunia
Subfertility
Investigation of Endometriosis
USS
Gold Standard = laparoscopy
Management of Endometriosis
C-OCP
Pain relief (NSAIDs/paracetamol)
Surgery to improve/preserve fertility
Associations with Endometrial Carcinoma
Lynch Syndrome
Presentation of Endometrial Carcinoma
Abnormal bleeding
Late - abdominal mass
Management of Endometrial Carcinoma
Hysterectomy
Chemo/radiotherapy
Types of Endometrial Carcinoma
Serous
Endometriod
What is the pathophysiology of endometroid endometrial carcinoma?
Unopposed oestrogen resulting in atypical hyperplasia
What is the pathophysiology of serous endometrial carcinoma?
Atrophic endometrium
Usually elderly, post-menopausal women
What is the genetics of Lynch Syndrome?
Autosomal dominant
Inheritance of defective DNA mismatch repair gene
