EndoCRYYYYYne Flashcards
Prednisone
synthetic GCC, pretty much fake cortisol anti-inflam, immune suppression, adrenocortial insufficiency - GCC excess
Fludrocortisone
Fake mineralcorticoid aldosterone mimic
Cosyntropin
ACTH faker use the diagnose adrenal insufficency
Beclomethsone
Synthetic GCC anti-inflam used for ASTHMA AND ALLERGIC RHINITIS
Estrogen
estrogen! inhibit FSh and LH to decrease ovulation OCP - Endometrial Ca, Breast CA, TEE
Diethylstilbestrol–DES
pseudo estrogen sucks: vaginal and cervical clear cell adenocarcinoma
Clomiphene
SERM Antagonist at hypothalamus: increase GnRH/FSH/LH Agonist at ovaries Rx: infertility -: too many babies!
Tamoxifen
SERM Antagonist for boobies! Agonist for bone. Breast cancer drug - Hot flash, endometrial cancer, VTEE
Raloxifene
SERM he does what tamoxifen does without the endometrial cancer risk
Anastrozole
inhibitor of aromatse Androgen stopper treat ER positive Breast CA - Arthralgias, myalgias
Progestin
Pseudo Progesterone rx: contraception prevent endometrial maturation, decrease uterine and tubal motility HRT DUB–stop bleed due to constant estrogen without progesterone Endometriosis–prevent proliferation of ectopic endometrial tissue
Testosterone
Testosterone make you a man! rx: hypogonad -: acne and being michael phelps
Flutamide
Anti-androgen competitive antagonist for androgen receptor rx: prorstate cancer
Finasteride
5a reductase inhibtor block conversion of T–>DHT rx: BPH and balding
Leuprolide
Fake GnRH intermittently: stimulate FSh and LH contiuously (on loop) inhibit FSH and LH RX: infertility and prostate cancer
Octreotide
Fake somatostatin decrease GI blood flow rx: esophageal variceal bleed
Oxytocin
Induce uterine contractions induction of labor
Vasopression
ADH doppleganger increase water abs RX: DI and vasodilatory shock
Desmopressin
long acting ADH doppleganger RX: DI
Levothyroxine
Fake thyroid hormone upregulate metabolism and energy expenditure rx: hypothyroid
Methimazole
inhibit theyroid peroixidse decrease the production of T3/T4 RX: Hyperthyroidism - agranulocyotis aplastic anemia allergy
Proypylthiouracil
PTU Peripheral thyroid utilizer stoper Stop perpipheral conversion of thyroid hormone Hyperthyroid
Insulin
insulin ctronol glucose in diabettes - hypoglycemia
Glyburide
Sulfonylurea enhace insulin release from B islet cells DM II
Nateglinide
inhance insulin release from B islet cell facilitate early meal mediated insulin secretion DMII
Exenatide
GLP doppleganger promote insulin synthesis and secretion DMII
Metformin
Decrease hepatic GNG DMII
Rosiglitazone
insulin sensitizer via PArry DMII - hepatotoxic
Acarbose
a glucosidase inhibitor delay intestinal abse of carbs DMII
Atoravastatin
block endogenous cholesterol synthesis reduce hypercholestertemia
Gemfibrozil
increase liprotein lipase activity Decrease TG, increase HDL, decrease LDL HyperTG
Niacin
decrease hepatic synthesis of TG RX: hyper TG - flush
Cholestryamine
disrupt bile acid recycling decease cholesterol, LDL and increase HDL and TG
Ezetimibe
inhibit intestinal cholesterol absoprtion rx: hypercholesterolemia
Alendronate
rx osteoporosis
Teriparatide
fake PTH treat osteopoosis
Cinacalcet
mimic bone CA treat hyper PTH
