Endocrinology

Question 1

Initial treatment for Myxoedema coma

Answer 1

Hydrocortisone( to treat adrenal insufficency) + Levothyroxine

Question 2

What is the maximum dosage and mechanism of action of Metformin?

Answer 2

2.2g/day. M.O.A : Acts on AMP activated protein kinase and increases insulin sensitivity and decreases hepatic gluconeogenesis

Question 3

What is the primary mode of action of orlistat?

Answer 3

Pancreatic lipase inhibitor - Which decreases absorption of lipids from intestines

Question 4

Drug advised for T2DM if metformin is contraindicated and has a risk of CVD

Answer 4

SGLT 2 inhibitors ( -Glifozins)

Question 5

Drug advised for T2DM if metformin is contraindicated and has no risk of CVD

Answer 5

DPP 4 inhibitors ( - gliptins)
Pioglitazone
Sulfonylureas
SGLT 2 inhibitors if NICE criteria are met

Question 6

Which oncogene is Medullary thyroid cancer associated with

Answer 6

RET oncogene

Question 7

What are the diseases in MEN type 2a

Answer 7

Medullary Thyroid Cancer
Phaeochromocytoma
Para Thyroid Hyperplasia

Question 8

What is seen in MEN type 2b

Answer 8

“MEN type 2 Be good - Habit”
Medullary Thyroid Cancer
Phaechromocytoma
Marfanoid habitus
Mucosal Neuromas

Question 9

What is seen in MEN type 1

Answer 9

Pit Para Pan
Pituitary adenoma
Parathyroid hyperplasia
Pancreatic tumors