Endocrinology Flashcards
1
Q
ACCORD trial.
Trial design.
A
Randomized clinical trial.
2
Q
ACCORD trial.
Inclusion criteria.
A
DM2 with HbA1c of 7.5% or more.
3
Q
ACCORD trial.
Exclusion criteria.
A
Frecuent or recent serious hypoglycemic events.
BMI >45.
4
Q
ACCORD trial.
Intervention studied.
A
Intensive therapy (HbA1c target: below 6% vs standard therapy (HbA1c target: 7-7.9%)
5
Q
ACCORD trial.
Outcomes.
A
– Occurrence of primary outcome (nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes): Intensive therapy: 352 vs Standard therapy: 371 (P=0.16)
– Deaths: Intensive therapy: 257 vs Standard therapy: 203 (P=0.04)
– Hypoglycemia requiring assistance and weight gain of more than 10 kg: More frequent in the intensive-therapy group (P<0.001)
