Endocrine Thyroid Flashcards
What are the 2 types of lipid soluble hormones?
Steroid and thyroid hormones
Where do lipid soluble hormones usually bind?
Bind to intracellular receptors in the cytoplasm or nucleus
What are the 2 types of water soluble hormones?
Protein and peptide bonds
What type of hormones are more soluble in blood and can be transported freely?
Water soluble
Where do water soluble hormones bind?
To cell surface receptors
What are the 2 protein/peptide cell surface receptors?
- GPCR
2. Receptor tyrosine kinases (RTK)
Nuclear receptor bind….
Lipid soluble hormones
What resides in cytoplasm and moves to the nucleus when bound to hormone ligand?
Type 1 NR
What resides in the nucleus, bunds hormone ligand, and affects transcription?
Type 2 NR
What is derived from cholesterol?
Androgens, progesterone, estrogens, mineralocorticoids, glucocorticoids
4 types of lipid soluble hormones
Steroid hormones
Vit D
Retinoic scud from retinol
Thyroid hormones
What is released by neurons and has a 1/2 life of seconds?
Catecholamines
What is degraded my proteases and has a 1/2 life of minutes?
Protein/peptide hormones
What has a 1/2 life of hours?
Steroid and thyroid hormones
What is oxidized and deiodinated to inactive forms?
Thyroid hormones
