Endocrine Pharmacology Flashcards
Name 1 hormone secreted by hypothalamus that is nt a peptide
Prolactin release inhibiting hormone (dopamine)
Somatostatin inhibits which hormone release
Growth hormone
Functions of somatotropin
Increases blood glucose level by inducing glucogenolysis
Positive nitrogen balance by increasing thr uptake of amino acids and inducing lipolysis
What are the stimuli for the secretion if growth hormone
Hypoglycemia, stess, fasting, excercise
Name the conditions associated with high and low levels of growth hormone
High- acromegaly (in adults), gigantism (in kids)
Low levels - dwarfism, simmonds disease
Conditions associated with high and low level of prolactin in the body
High - galactorrhoea, amenorrhea, gynaecomastia, hypercholestremia
What are menotropins
A synthetic preparation obtained from thr urine of menopausal women. Used for treating infertility
Name some synthetic hormones and their uses
Urofollitropin or menotropin (pure FSH) - used for ovulation in women with polycytic ovarian disease, cryptoorchism (hidden testes), hypogonadism
How many amino acids does oxytocin have
9
Describe the actions of oxytocin
Inc uterine contraction via IP3 DAG pathway
Milk ejection
ADH like action on kidney
Action of sermorelin and whatnis sermorelin
Sermorelin is a growth hormone releasing hormone agonist
*It is used to diagnose pituitary responsiveness and GH secretary capacity
What controls GHRH secretion
Ghrelin
Name some anti-estrogens
Clomiphene citrate, fluvestrant, danazol
What is clomiphene used for
Infertility in women is intact hypothalamic-pituitary axis and sufficient prod of estrogen
Use of fluvestrant
For women is progressive breast cancer after tamoxifen
