Endocrine Pancreas Review Questions (Vieira) Flashcards
Which cells are responsible for the production of Glucagon?
Alpha Cells
Which of the following is an inhibitor of secretion? A. Glucose B. Amino Acids C. Fatty Acids D. Somatostatin
D. Somatostatin
Which glucose transporter is insulin sensitive?
GLUT4
Which glucose transporter is important for the glucose entrance in the beta cell?
GLUT2
T/F The acute phase of insulin secretion involves the synthesis of new insulin by beta cells.
False.
What is the name of the receptor that insulin binds to?
Receptor Tyrosine Kinase
Which of the following is a hormone released immediately after hypoglycemia? A. Cortisol B. Catecholamine C. Growth Hormone D. Somatostatin
B. Catecholamine
Under insulin action, the liver will: A. Increase gluconeogenesis B. Decrease gluconeogenesis C. Increase glycogenolysis D. Increase lypolysis
B. Decrease gluconeogenesis
Which of the following is NOT true about Glucagon?
A. It is a polypeptide hormone
B. Induces liver ketogenesis
C. Is stimulated by hyperglycemia
D. In carnivores it is realeased after protein ingestion
C. Is stimulated by hyperglycemia
Which of the following is NOT true about gluconeogenesis? A. Is made by the liver B. Is made by the kidneys C. Alanine and Glutamine are stubstrates D. FFAs are a substrate
D. FFAs are a substrate
Which enzyme is responsible for the release of FFAs and glycerol in the blood during diabetes? A. Hormone-Sensitive Lipase B. Hormone-Sensitive Amylase C. Hormone-Sensitive Phosphate D. Hormone-Sensitive Anhydrase
A. Hormone-Sensitive Lipase
Which of the following is NOT true regarding Type I Diabetes?
A. Is more common in dogs
B. Is caused by a relative insulin deficiency
C. Hyperglycemia is a consequence of decreased glucose uptake
D. Cataracts are a possible complicaton
B. Is caused by a relative insulin deficiency
Which of the following is NOT true about Diabetes Mellitus Hyperglycemia?
A. Is a consequence of decreased glucose uptake in the muscle
B. Is a consequence of decreased glucose uptake in the adipose tissue
C. Is a consequence of increased gluconeogenesis
D. Is a consequence of glycogenesis
D. Is a consequence of glycogenesis
Which hormone produced by the beta cells can aggregate causing irreversible beta cell damage in cats?
Amylin
Amylin aggregates and forms the amyloid. Amyloid depostion in pancreatic islets leads to amyloidosis
T/F During the early stages of insulin resistance beta cells increase insulin production
True
Which of the following is NOT true about the pathophysiology of Type 2 Diabetes?
A. Increased production of insulin perpetuates amyloidosis
B. Decreased production of insulin perpetuates amyloidosis
C. Glucotoxicity is a reversible damage
D. Obesity decreases insulin sensitivity
B. Decreased production of insulin perpetuates amyloidosis
Which of the following is NOT a ketone body? A. Acetoaccetate B. Beta hydroxybutyrate C. Sorbitol D. Acetone
C. Sorbitol
Which of the following is NOT true regarding ketone bodies? A. Production is stimulated by glucagon B. Renal threshold is high C. Decrease the [H+] in the blood D. Are source of energy for the brain
C. Decrease the [H+] in the blood
Which of the following is NOT expected in a patient with DKA? A. Decreased pH B. Decreased HCO3 C. Normal Anion Gap D. Increased pCO2
C. Normal anion gap
Why is hyperventilation present in DKA? A. To increase pCO2 B. To decrease pCO2 C. To decrease pH D. To increase [H+]
B. To decrease pCO2
Which of the following does NOT contribute to the hypokalemia in DKA? A. Increased secretion of aldosterone B. Osmotic diuresis C. Acidosis D. Hypovolemia
D. Hypovolemia
Which of the following hormones is considered the most ketogenic? A. Epinephrine B. Glucagon C. Cortisol D. GH
B. Glucagon
T/F For the synthesis of ketone bodies to be enhanced there must be and increased mobilization of Free Fatty Acids.
True
The increase in ketone bodies without interference in the blood pH is called: A. Ketonuria B. Ketogenesis C. Ketosis D. Ketoacidosis
C. Ketosis
