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Clinical Chemistry 2 > Endocrine - Growth Hormone > Flashcards

Endocrine - Growth Hormone Flashcards

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1
Q

Hormone

A

Chemical signals or messengers
Made by specific cells

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2
Q

Classification of a hormone is based on

A
  1. Chemical structure e.g.amine,peptide,protein
  2. Mechanism of action
  3. Stimulation of the gland
  4. Effect on the target organs
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3
Q

Structural categories of hormones

A

Amines
Peptide
Protein
Glycoprotein
Steroids
Fatty acids

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4
Q

Amines

A

Derived from amino acids, have very short half-life

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5
Q

Peptide

A

Made of unbroken chain of amino acids, that is 50 or less amino acids
Most human peptides are 20 amino acids

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6
Q

Hydrophilic hormones

A

Water soluble, cannot cross cellular membrane

Peptide
Protein
Amine

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7
Q

Hydrophobic hormones

A

Can cross cellular membrane
Uses blood bound to carrier protein for transport

Steroids

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8
Q

Proteins

A

Made of chain of amino acids, and composed of greater than 50 chains

Has protein structures: primary, secondary, tertiary

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9
Q

Glycoprotein

A

Conjugated proteins with carbohydrates

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10
Q

Steroids

A

Derived from lipids, composed of cholesterol
Hydrophobic
Cross cellular membrane due to lipid

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11
Q

Fatty acids

A

Derived from arachidonic acid
Rapidly degrades, present in seconds only

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12
Q

Somatotropin

A

Another name for growth hormone

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13
Q

Structure of Growth hormone

A

Peptide

Or

One peptide with two intramolecular disulfide bridges

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14
Q

Effector or trophic hormone

A

Stimulation of tissue growth, or increase of size

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15
Q

Stimulation of GH

A

Gowth Hormone-Releasing Hormone GHRH

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16
Q

Inhibition of GH

A

Somatostatin or SS

17
Q

GH mode of secretion

A

Via pulses with average interval of 2 to 3 hours with peak of onset of sleep

18
Q

Peak amount of GH

A

During onset of sleep

19
Q

Test for GH

A

ELISA

20
Q

ELISA

A

Enzyme Linked Immunosorbent Assay
Sandwich method

21
Q

Sandwich method

A

Method used in ELISA in growth hormone testing

Clinical Chemistry 2 (2 decks)

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