Endocrine

Question 1

Hashimoto thyroiditis

Answer 1

AKA chronic lymphocytic thyroiditis

Mononuclear infiltrate with lymphocytes and plasma cells, often with germinal centers

Residual follicles surrounded by Hurthle cells

Question 2

Hurthle cells

Answer 2

Found in Hashimotos

Large oxyphilic cells with granular cytoplasm – represent follicular epithelial cells that have undergone metaplastic change in response to inflammation

Question 3

Papillary thyroid cancer

Answer 3

Branching papillary structures with concentric calcification (psammoma bodies) and ground glass/empty nuclei (orphan annie)

Question 4

Riedel thyroiditis

Answer 4

Extensive fibrosis extending into the surrounding structure

Typically hard and fixed to surrounding structures

Question 5

Graves thyroid

Answer 5

Follicular epithelium is tall and crowded with hyperactive reabsorption causing scalloped edging around the colloid

Question 6

Subacute granulomatous (de Quervain) thyroiditis

Answer 6

Disrupted follicles with mixed cellular infiltrate with multinuclear giant cells

associated with URI and thyroid is tender and painful