Endocrine Flashcards
fetal thyroid production depends on the mother’s ____ levels for its thyroid hormone synthesis
iodine
Thyroid is from what layer in development? What pharyngobronchial pouch?
endoderm
4th pharyngobronchial pouch
what thyroid hormone does NOT cross placenta
TSH
Fetal T3 and T4 and TSH and transition after birth
T4 rise after 20 weeks
T3 rise after 30 weeks (thyroid gland can convert T4 to T3 by this time)
TSH surge (due to COLD) after birth
along with T3 and T4.
if baby has congenital hypothyroidism (1:3000-4000) live birth, what other congenital defect you need to think about
slightly increase in congenital heart defect (5.2-9% while general population 2.5-9%)
2% w/ family hx.
if free T4 is normal, but T4 total is low, this means there are low total thyroid hormon but also low binding TBG. so enough free T4 to function.
anterior pituitary gland from where
posterior pituitary gland from where
Rathke’s Pouch (adenophypophysis)
3rd ventricle (ectoderm, neurohypophysis)
hCG stablize SRY
CAH is what genetic pattern
all Autosomal RECESSIVE.
when can you clear salt wasting crisis (by what DOL)
day 10
5 alpha reductase deficiency
no testicular descend, at beginning
but age 12, more testosterone, –> become boy.
how to tell difference between CAH baby and pseudohypoaldosteronism
Both have salt wasting, high K, and low BE.
Pseudohypoaldosteronism has HIGH Aldosterone.
But CAH has limited Aldosterone
An infant of a diabetic mother has hypocalemia secondary to
Reduced transplacental transfer of calcium secondary to increased urinary excretion of Ca2+ and Mg2+
Mom pees more due to hyperglycemia
if baby has low Ca, also need to replace what electrolyte
Mg
Mg is needed for PTH release
(but too much Mg, hyperMg, can inhibit Ca influx at the neuromuscular jxn leading to decrease tone in neonate)
Pseudohypoparathyroidism gene pattern
AD
