Endocrine Flashcards
stress response step 1
Alarm phase- energy reserves mobilized (glucose)
epinephrine, increased alertness, circulation change
Resistance phase
occurs after more than a few hours, cortisol is administered, conservation of glucose, conservation of salt and H2O
Exhaustion phase
weeks to months, mineral imbalances cause infections, organ failure, cardiovascular damage, loss of lipid reserves
Hirsutism
excessive hair growth
Hypophysectomy
surgical removal of pituitary
prolactinoma
pituitary tumor, hypersecretion of prolactin disturbances in women
psychosocial dwarfism
dwarfism, failure to thrive, stress and emotional disorders that support growth hormone are failing
Thyroid storm
a sudden increase in symptoms of hyperthyroidism
endocrine cascade
stress goes to the hypothalamus, which then administers CRH, and goes to the anterior Pituitary which produces ACTH, ACTH goes to the adrenal gland and produces cortisol
Endocrine glands
Adrenal, Hypothalamus, Pituitary, Thyroid, pineal, thymus glands, pancreas, gonads
Hormone
Chemical substances secreted by cells into extracellular fluids that regulate metabolic function
Neurotransmitter
Variety of amine and peptide hormones released to regulate digestive functions
neurohormone
released by nervous system structure in response to nerve stimulation
pheromone
chemical released by exterior of organism to receiving individual of same species
receptors
inside or on surface of cell, bind to substance and cause effect, protein
what do receptors do
receptors allow binding of hormones and help differentiate into target receptors
Hormones vs. neurotransmitters
Hormones produced in endocrine and secreted in blood, neurotransmitters in synapse
intracellular receptors vs. membrane bound receptors
intracellular in cytoplasm, membrane convert
Protein vs. steroid hormones
Protein react with receptors on surface of cell, steroid act with receptor sites inside a cell
up regulation
target cells form more receptors in response to increasingly higher levels of specific hormones
down regulation
loss of receptors prevent overreacting to high hormone levels
hormone action
- Change in plasma membrane permeability
- synthesis of proteins or regulatory molecules
- enzyme activation/deactivation
- induction of secretory activity
- stimulation of mitosis
exocrine gland
have ducts, non-hormonal products go to membrane (saliva, sweat)
Endocrine glands
ductless glands, hormones into blood and lymph
steroid hormone action
diffuse into target cells and attach to DNA to transcript
1. lipid derivatives, synthesized from cholesterol ( androgen, estrogen, progestrins)
protein hormone action
Amino acid-based molecules- melatonin, thyroxin, catecholamines, peptides
Diabetes insipidus
results in secretion of large amounts of urine, head trauma
Diabetes mellitus
hyposecretion of insulin, lots of urine, hunger and food consumption–> type 1/2
glucocorticoid
influence metabolism, stimulated by ACTH, cortisol to maintain blood sugar and volume
blood nutrient
vitamins, minerals and antioxidants
mineralcorticoid
aldosterone, involved with maintaining salt balance
insulin
glucagon
secreted by A cells to liver, promote glycogen to glucose, stimulated =low glucose
growth hormone
targets body cells, primarily bone and muscle, increase size, stimuli= GHRH, GHIH
cortisol
influence metabolism, part of stress response
T3/T4
triiodothyronine- formed at target tissues, 3 iodine, increase temp, metabolism, development, everything
calcitonin
maintain Calcium in b lood, thyroid
oxytocin
positive feedback, hypothalamus then in blood from pituitary
ADH
antidiuretic hormone- targets kidney to resorb water in blood, less pee
prolactin
targets breast secretory tissue to promote lactation- stimuli= PRH, PIH
TH
made by thyroid after TSH stimuli
TSH
stimulates development and secretory activity of thyroid
melatonin
control day.night cycles, body temp, sleep, appetite
LH
luteinizing hormone- targets gonads to promote hormones
FSH
follicle stimulating hormone- targets gonads to stimulate gamete production
epinephrine
reinforce and prolong fight/flight response, target nervous system to increase heart and metabolic
estrogen
maturation of organs, promote breast development, and cyclical changes
testosterone
initiates maturation of organs, promotes sperm and reproductive organs
aldosterone
helps to maintain salt levels in body
master gland– pituitary
in brain, controls function of most endocrine glands
hypothalamus purpose and type
produces hormones, TSH, ACTH, LH, PRL, oxytocin, ADH
homeostasis
Steroid hormones produce their effects by
interacting with DNA
which of the following best describes the difference between endocrine and exocrine
endocrine glands secrete their products directly into blood, exocrine glands secrete through ducts
insulin caused
decrease in concentration of glucose
specific site for glucagon production
alpha cells in pancreas
epinephrine ; adrenal
aldosterone; pituitary
cortisol; adrenal
ACTH; pituitary
growth hormone; thyroid
growth hormone releasing hormone; hypothalamus
4
- growth hormone is secreted by pancreas
-growth hormone can be found in blood
-growth hormone is secreted throughout life
-growth hormone promotes protein synthesis in its target issues
3
homeostasis mechanism
stimulus
sensor
integrator
effector
response
stimulus, sensor, integrator, effector and target of low glucose
blood glucose concentration, receptors in pancreas, pancreas elevate alpha cells, glucagon effects, target is liver cells
islets of Langerhans
islands of endocrine cells throughout pancreas
how are islets related to type 2 diabetes?
beta cells are destroyed and are therefore not functional to help lower glucose