Endocrine

Question 1

3 D’s that increase serum uric acid

Answer 1

Drugs - ASA, diuretics, levodopa, ?ACEI/BB, tacrolimus
Diet - purine rich foods
Disease - malignancies, CKD, HTN, obesity

Question 2

Gout may self resolve in

Answer 2

3-7-14 days

Question 3

non-pharm strategies to prevent gout

Answer 3

hydration
wt loss
stop smoking
exercise
change diet

Question 4

T/F? For acute attack of gout, start at low dose therapy then gradually increase.

Answer 4

False, start high dose then taper colchicine, NSAID or corticosteroids
* Avoid NSAID and corticosteroid combo (GI issues)

Question 5

Gout considerations for renal dysfunction/elderly

Answer 5

Decrease dose of allopurinol, cholchicine and avoid NSAIDs

Question 6

T/F? Avoid NSAIDs in gout with concurrent CVD.

Answer 6

True

Question 7

Naproxen dose for acute gout flare

Answer 7

500mg TID then 250–500mg BID x 1-2 weeks

Question 8

Colchicine dosing for acute gout

Answer 8

(0.6mg tab)

Question 9

Monitoring for colchicine

Answer 9

CK (risk of rhabdo), CBC, renal function

Question 10

Montiroing for allopurinol

Answer 10

sUA & renal function x 3 months, goal <300-360 umol/L

Question 11

What two medications have class A evidence for CV benefit for DM?

Answer 11

epagliflozin (SGLT-2) and liraglutide (GLP-1)