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pharmacology > endocarditis > Flashcards

endocarditis Flashcards

1
Q

cipro ADE

A

not if < 18

tendon problems

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2
Q

Daptomycin ADE

A

a lipopeptide
myopathy and rhabdo
monitor: CPK (creatine phosphao kinase)

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3
Q

Gentamicin ADE

A

a aminoglycoside
nephro and oto toxicity
neuromuscular blockade (paralysis)
dont use with other nephrotoxic: diuretics, NSAIDs

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4
Q

Linezolid ADE

A

an oxazolidinone
optic and peripheral neuropathy
thrombocytopenia (low platelets)

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5
Q

rifampin ADE

A

a TB drug

hepatotoxicity

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6
Q

vancomycin ADE

A

glycopeptide (very good vanco glycopeptide)
nephrotoxicity
red man syndrome (rash u can prevent with antihistamine before or slow infusion 1-2 hrs)

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7
Q

IE most common organisms

A

Staph (MC) treat with naficillin
Strept treat with pcn g or ceftriaxone
Entero treat with ampicillin

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8
Q

IE MC in IV drug users

A

Tricupsid and Staph Aureus
tx with Naficillin (kidney) or Oxacillin (liver)
+/- aminoglycoside (genta/tobra)

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9
Q

janeway lesions

A

macules on palms and soles
not tender
+ culture

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10
Q

osler node

A

nodules on fingers and toes
tender
- culture

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11
Q

empiric IE treatment

A

IV vancomycin 6 wks

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12
Q

native strept PCN S and R

A

-PCN G or Ceft 4 wks
+ genta 2 wks
-vanco 6 wks if allergy

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13
Q

native staph oxacillin S and R

A 
naficillin 6 wks
oxacillin 6 wks
cefazolin (1st gen) 6 wks
vanco 6 wks if allergy
Dapto 6 wks if MSSA MRSA
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14
Q

native staph oxacillin R

A

vanco 6 wks

dapto 6wks

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15
Q

prosthetic strept PCN S and R

A

-PCN G or Ceft 6 wks
+ genta 2 wks
-vanco 6 wks if allergy

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16
Q

prosthetic staph oxacillin S and R

A

-naficillin or Oxacillin
+ rifampin 6 wks
add genta for 2 wks treatment

-vanco + rifampin 6 wks if allergy
add genta for 2 wks treatment

17
Q

prosthetic staph oxacillin R

A

vanco + rifampin 6 wks

add genta 2 wks

18
Q

Native/Prosthetic entero

amp, pcn, vanco susceptible

A

amp or pcn g + genta
4 weeks if <3 months symptoms
6 weeks if >3 months symptoms

amp + ceft 6 wks if CrCl < 50

vanco + genta 6 wks if pcn allergy

19
Q

native/prosthetic entero

pcn resistant

A

amp-sulb + genta 6 wks

vanco + denta 6 wks

20
Q

native/prosthetic entero faceium

resistant to pcn, vanco, aminoglycoside

A

linezoid or Daptomycin 6 wks

21
Q

culture negative

native valve

A

vanco + cefepime if acute

vanco + amp-sulb subacute

22
Q

culture negative

<1 yr prosthetic

A 
vanco + 
cefepim + 
rifampin + 
gentamicin 
all for 6 wks
23
Q

culture negative

>1 yr prosthetic

A

vanco + ceftriaxone 6 wks

24
Q

bartonella

A

suspected: ceft + genta +/- doxy 6 wks 2 wks

+ culture: doxy + genta 6 wks 2 wks

pharmacology (9 decks)

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