Endocarditis Flashcards

1
Q

Native valve vs. replaced valve difference in bacteria found

A

Coagulase negative staph in non native valve. Has a prediliction for non native surfaces and grow a microfilm.

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2
Q

Native valve endocarditis bacteria is typically

A

coagulase positive staph

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3
Q

HACEK

A

Haemophilus, aggregatibacter, cardiobacterium, eikenella, kingella

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4
Q

Endocarditis: 4 main principles to treatment regimens

A

1) bacteriocidal regimen if possible
2) Takes prolonged course of therapy (4-6weeks)
3) Aggressive dosing (typically higher range
4) source control

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5
Q

methicillin affects the

A

Kidneys

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6
Q

Oxaciilin affects the

A

liver

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7
Q

nafcillin affects the

A

bone

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8
Q

always use actual body weight when dosing vancomycin

A

true

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9
Q

loading dose of any drug is not dependent on how its eliminated. So how is it dosed?

A

Via body weight. treat it like a bucket and need address volume of distribution.

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10
Q

in MSSA: beta lactams are superior to vancomycin

A

beta lactams are rapidly bacteriocidal and vancomycin is slowly bacteriocidal

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11
Q

ampicillin gentamycin: Gent does what in this combo?

A

the gent makes the antibiotic bactericidal vs. just static.

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12
Q

biofilm: polysaccharide matrix that houses microbes and adheres to foreign/plastic surfaces. Rifampin does what to it?

A

It can help penetrate the biofilm but it does not degrade it. to treat endocarditis, you will need rifampin and another abx to treat concurrently

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