Endocarditis Flashcards
Native valve vs. replaced valve difference in bacteria found
Coagulase negative staph in non native valve. Has a prediliction for non native surfaces and grow a microfilm.
Native valve endocarditis bacteria is typically
coagulase positive staph
HACEK
Haemophilus, aggregatibacter, cardiobacterium, eikenella, kingella
Endocarditis: 4 main principles to treatment regimens
1) bacteriocidal regimen if possible
2) Takes prolonged course of therapy (4-6weeks)
3) Aggressive dosing (typically higher range
4) source control
methicillin affects the
Kidneys
Oxaciilin affects the
liver
nafcillin affects the
bone
always use actual body weight when dosing vancomycin
true
loading dose of any drug is not dependent on how its eliminated. So how is it dosed?
Via body weight. treat it like a bucket and need address volume of distribution.
in MSSA: beta lactams are superior to vancomycin
beta lactams are rapidly bacteriocidal and vancomycin is slowly bacteriocidal
ampicillin gentamycin: Gent does what in this combo?
the gent makes the antibiotic bactericidal vs. just static.
biofilm: polysaccharide matrix that houses microbes and adheres to foreign/plastic surfaces. Rifampin does what to it?
It can help penetrate the biofilm but it does not degrade it. to treat endocarditis, you will need rifampin and another abx to treat concurrently