Endocannabinoid System

Question 1

1964

Answer 1

-THC Discovered at the Weizmann Institute of Science in Rehovot, Israel by Dr. Raphael Mechoulam

Question 2

DR. RAPHAEL MECHOULAM

Answer 2

-Discovered THC at the Weizmann Institute of Science in Rehovot, Israel in 1964

Question 3

1973

Answer 3

-First Opiate Receptors Discovered in the Human Brain

Question 4

OPIOID RECEPTORS

Answer 4

-Distributed Widely in the Brain, Can be Found in the Digestive Tract and Spinal Cord

Question 5

1975

Answer 5

-Discovered the Human Brain has “Endogenous Opiates” or “Endorphins”

Question 6

1988

Answer 6

• Allyn Howlett and William Devane Discover First Cannabinoid Receptors in the Brain
• Named Cannabinoid 1 Receptors or CB1

Question 7

CANNABINOID 1 RECEPTORS or CB1

Answer 7

• Discovered by Researcher Allyn Howlett and Grad Student William Devane in 1988
• Found Mostly on Neurons in the Spinal Cord, Brain, and Peripheral Nervous System
• Hence Role of Cannabinoids on Pain Modulation, Memory Processing, Motor Control
• Also Found in Skin
• Evolved 600 Million Years Ago

Question 8

1992

Answer 8

• Israeli Researchers Found an Endogenous Cannabinoid

- Named N-Arachidonoyl Ethanolamine or Anadamide

Question 9

N-ARACHIDONOYL ETHANOLAMINE or ANANDAMIDE

Answer 9

-Discovered by Israeli Researchers in 1992

Question 10

1993

Answer 10

• Cannabinoid Receptors Discovered in the Immune System
• Cannabinoid 2 Receptors or CB2
• Subsequently Discovered a Second Endocannabinoid, 2-Arachidonoyl Glycerol or 2-AG

Question 11

HOW MANY ENDOCANNABINOIDS HAVE BEEN DISCOVERED?

Answer 11

Five total, but anandamide and 2-AG are the most important.

Question 12

CANNABINOID 2 RECEPTORS or CB2

Answer 12

• Located Mainly in Immune Cells such as the Spleen, Tonsils
• Also Found in Skin
• Discovered in 1992
• Evolved 600 Million Years Ago

Question 13

WHERE ARE CANNABINOID RECEPTORS ALMOST COMPLETELY MISSING?

Answer 13

Cannabinoid Receptors are almost completely missing from the middle area of the human brain where systems critical to keep humans alive, such as heartbeat and breathing, are found, whereas opioids have a profound affect on the midbrain. Hence why cannabis is so safe and does not cause death.

Question 14

WHY IS CANNABIS SO SAFE?

Answer 14

Because cannabinoid receptors are almost completely missing in the midbrain, where systems critical to keep humans alive, such as heartbeat and breathing, are found.

Question 15

ENDOCANNABINOID SYSTEM (ECS)

Answer 15

• Main Function to Regulate Homeostasis
• Works By Sending One Neuron to Another
• Involved with Regulation of Appetite, Pain, Memory, Mood, Movement in the Human Body
• Affects Many Biological Processes Including Appetite and Sleep
• Provides Bridge Between Body and Mind

Question 16

HOMEOSTASIS

Answer 16

• The Ability to Maintain Stable Internal Conditions Needed for Survival or Optimal Health
• Disease is a Result of the Body’s Inability to Acheive Homeostasis

Question 17

WHAT HEALTH CONDITIONS HAVE CANNABINOIDS BEEN PROVEN TO PROVIDE ASSISTANCE IN BATTLING AGAINST, AND HOW?

Answer 17

Brain trauma, spinal cord injury, and strokes by interrupting the uptake of neurotransmitters that drive the progression of various diseases.

Question 18

CB1 RECEPTOR and CANNABIS

Answer 18

• Useful For:
  
  • Anxiety and Stress
  • Increase in Euphoria and Feelings of Happiness
  • Decrease in Convulsions and Tremors
  • Coping with Chronic Pain

Question 19

CB2 RECEPTORS and CANNABIS

Answer 19

• Useful For:
  
  • Decreasing Cancer Cells
  • Boosting the Immune System
  • Coping with Alzheimer’s

Question 20

PHYTOCANNABINOIDS

Answer 20

• Contained Within Plants

- THC and CBD are Two Types

Question 21

ENDOCANNABINOIDS

Answer 21

• Moderate Flow of Neurotransmitters, Keeping Our Nervous System Running Smoothly
• Found Naturally in the Human Body
• Anandamine and 2AG are Two Types