ENDO Quiz Flashcards
When fasting –> what happens to the blood glucose level ?
stays the same
note: glucose goes into pancreas–> pancreas releases insulin –> insulin binds to receptor on glut 4 –> pumps glucose into cells
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What does Insulin release do to:
a) Glycogen synthase
b) glycolysis in liver + muscle
c) gluconeogenesis
What does Insulin release do to:
a) Glycogen synthase —-> turns on
b) glycolysis in liver + muscle —-> turns on
c) gluconeogenesis —> switches off
Note: Insulin stimulates Glycogen synthesis
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When fasting –> what happens to the insulin ?
insulin levels fall - other substrates are used : glucose glycogen triglyceride protein
During starvation, what does the liver switch on?
gluconeogenesis –> SWITCHED ON
ketogenesis –> switched on
What does insulin do to:
a) keton production
b) fat generation
c) glucose uptake
insulin:
- suppresses ketone production
- stimulates fat generation
- stimulates glucose uptake from blood into tissue
T1DM causes / doesn’t cause acidosis
- it causes ACIDOSIS
What happens if there is total absence of insulin?
what does the liver do?
- when insulin = 0 liver produces large amounts of ketone
- -> causes DKA
can cause death
how would you manage DKA ?
how would you manage DKA
- rehydrate with normal saline
- IV Insulin infusion
How would you treat T1DM ?
treating T1DM
- insulin
- diet management
What is T2DM ?
- resistance to the action of insulin
What is T2DM ?
- resistance to the action of insulin
What happens in T2DM ?
- you make insulin
- but effect is weak
- so only some glucose are let in via GLUT 4
-SO patients are: hyperglycemic –> without ketosis
T2DM patient show DKA (true / false?)
FALSE
they dont
