Enamel Flashcards
Ameologenins
Low molecular weight proteins and hydroponic (90%)
Nonamelgenins
High molecular weight proteins
What are the three stages amelogensis is broken down into how many stages?
Three stages
- Presecretory
- Secretory
- Maturation
What are the 6 stages of amelogenesis
Morphogenic, organizing (differentiation) , secretory (formative), maturative, protective and desmolytic
What stages are in the pre - secretory stages of amelogenesis ?
Morphogenesis and differentiation
What happen in the morphogenesis stage of amelogenesis?
In this stage the ameloblast aren’t fully differentiated and before they are they interact with the adjacent mesenchyme cells determining the shape of the ADJ and crown.
How do the cell look during morphogenesis ?
The cells are short columnar with large oval nuclei.
What happens during organization (differentiation) stage
The cells of the inner enamel epithelium differentiate the become elongated which causes their nuclei to shift proximally towards the stratum intermedium.
The basement membrane which supports the pre ameloblast disintegrates after the deposition of dentin and during differentiation.
What happens after the differentiation stage and the secretory stage?
The formation of dentin by odontoblast.
What happen in the secretory stage of amelogenesis?
- The cells of the ameloblast develops blunt processes which penetrate the basal lamina and protrudes into the Predentin so the basement membrane is fragmented.
- the cell organelles of the ameloblast are increased.
- the cells begin to release hydroxyapatite crystals which are parallel to one another and interdigitates with the crystal of dentin in this initial layer.
- when this first increment of enamel is formed the ameloblast begin to move away from the dentin surface and as they do each cell forms a conical projection called a Tomes process.
aprismatic enamel
At the end of the secretory stage, ameloblasts lose their Tomes’ process and produce a thin layer of aprismatic enamel
How will the TP secrete granules ? (SS)
They secrete granules perpendicularly to the tp membrane.
What two sites are enamel secreted from ( SS)
Proximal site of tp which forms interrod enamel.
The distal portion of tp which fill the pits with matrix (enamel rods)
Difference between interrod enamel and rods.
The structure - there cells have different orientations
What happens during maturation?
- The ameloblasts undergo significant reduction in the height and a decrease in its volume and organelle content.
- Next the water and organic materials are selectively removed from the enamel while the additional inorganic material is introduced.
- partial mineralization during matrix formation, 25-30% of the total mineralization.
- second stage mineralization will be completed.
- The maturation of the crystals begins at its dentinal end and progress to the outer surface.
- Maturation occurs by the growth of the primary crystals till they fuse together
The fibrils between the crystals will become thinner.
Protective
After complete formation and mineralization of enamel the ameloblast forms 3-4 layers of stratified epithelium that covers the enamel called reduced enamel epithelium.