Emr Flashcards
Pharmaceutics
The science of dispensing drugs
Pharmacokinetics
The study of how the body handles a drug over a period of time. (Absorption distribution biotransformation excretion)
Bioavailability
The measure of the amount of a drug that is still active after it reaches its target tissue after considering all of the absorption factors.
In the body a drug may be stored in various sites known as drug reservoirs. Two types are:
– Plasma reservoirs
– tissue reservoirs
Biotransformation
The metabolism of drugs. – Transform the drug into a more or less active metabolite.
-make the drug more water soluble (for excretion)
Biotransformation occurs in the following locations:
– Liver -kidneys – lungs -intestines – plasma
Drug half-life
The time required for the total amount of a drug in the body to diminished by one-half.
For example if a patient received a single dose of a drug with the half-life of five hours, the patient would have half of the dose left five hours later, and one quarter of the original dose after 10 hours.
Pharmacodynamics
The study of the mechanisms by which specific drug dosages act to produce biochemical or physiological changes in the body.
Bind to a receptor site, change the physical properties of a cell, chemically combine with other chemicals, alter our normal metabolic pathway.
Chemicals that stimulate a receptor site generally fall into two broad categories.
- Agonists
- find to the receptor and cause it to initiate the expected response. - Antagonists
- bind to the receptor site but do not cause the receptor to initiate the expected response.
The nervous system is broken into two categories which are…
The central nervous system and the peripheral nervous system.
The central nervous system is broken into two categories which are…
The brain and the spinal cord.
The peripheral nervous system is broken into two categories which are…
Somatic nervous system and the autonomic nervous system
The autonomic nervous system is broken into two categories which are…
The sympathetic nervous system [adrenergic] and the parasympathetic nervous system [cholinergic]
The sympathetic nervous system (adrenergic) is broken into two categories which are…
Alpha receptors and beta receptors
Alpha-1 vasoconstriction
Beta-1 increased heart rate
Beta-2 Bronchodilation
Epinephrine will bind to which receptor sites of the sympathetic nervous system?
Epinephrin binds to the alpha-1, beta-1, and beta-2 receptors.
Resulting in bronchodilation, drying of the bronchial mucous membranes, and increased heart rate and blood pressure.
Parasympathetic nervous system
Returns the body to normal (acetacholine)
Works together with the sympathetic nervous system but one more than the other.
Salbutamol will bind to which receptors of the sympathetic nervous system?
Salbutamol binds to the beta-1 receptor (increase in heart rate and blood pressure) and beta-2 receptor (promotes bronchodilation)
The six rights of medication
Right patient Right drug Right time Right dose Right route Right documentation
What else do you check before administering a drug?
Colour
Clarity
Concentration
Expired date
Medications that an EMR can administer with off-line medical direction and will carry in an ambulance
ASA (acetylsalicylic acid)
Oral glucose
Medications that an EMR may assist with as part of their online medical direction and if the patient has a prescription for the medication.
- Salbutamol (ventolin)
- Ipratropium bromide (atrovent)
- epinephrine (adrenalin)
Glucose
- indications
- dose
-signs and symptoms of hypoglycaemia with a confirmed BGL less than 3.8 mmol/L
-Adult 25g
May repeat dose in 10min is necessary
ASA
- indications
- Dose
- Ischemic chest pain
- adult 160 to 325 mg chewed
(2-4, 80mg tablets)
Epinephrine
- indications
- dose
-anaphylaxis
- adult 0.3 mg IM EpiPen
- Paediatric 0.15 mg EpiPenJr
Salbutamol (ventolin)
- indications
- dose
-Severe bronchospasm due to chronic bronchitis or shortness of breath due to asthma.
- adult 6-20 puffs each puff being 100 mcg/spray
- paediatric
Ipratropium bromide (Atrovent)
- indications
- dose
- severe bronchospasm due to chronic bronchitis or shortness of breath due to asthma
- 1 to 4 puffs PRN to a max of 10 puffs, each puff being 20 mcg/spray
Nitroglycerin
- suspected MI or angina
- 0.4 mg SL Spray