Embryology (Week 1 & 2) Flashcards

1
Q

Neural folding is completed first at which region

A

Cervical

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2
Q

The kidneys will develop from which layer

A

The intermediate mesoderm

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3
Q

What is the most common site for an extrauterine pregnancy

A

Attachment to the ampulla of the fallopian tube

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4
Q

The mesonephros are present during which weeks

A

4-8

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5
Q

What day is associated with morula development

A

3-4 days , ~96 hrs

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6
Q

What vitamin is associated with a reduction in Spina Bifida

A

Folic Acid - vitamin B9

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7
Q

Human chorionic gonadotrophin is secreted by what cell layer

A

Trophoblast

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8
Q

Where does the epithelial layer of the gastrointestinal tract originate

A

The endoderm

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9
Q

The permanent kidney occurs is what stage

A

Metanephros

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10
Q

What week does the embryonic period finish at

A

8 weeks

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11
Q

The somatic and splanchnic lateral mesoderm together line what

A

The intra-embryonic coelom

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12
Q

Protrusion of both nerve tissue and meninges is classed as what type of neural tube defect

A

Meningomyelocele

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13
Q

The epididymis and ductus deferents develops from what duct

A

The mesonephric duct

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14
Q

Somites develop in a caudo-cranial or cranio-caudal sequence

A

Cranio-caudal

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15
Q

The failure of formation of the septum transversum results in what pathology

A

Diaphragmatic hernia

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16
Q

What cellular layer does the axial skeleton derive from

A

The para-axial mesoderm

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17
Q

What is the name given to a birth defect of the abdominal wall where the intestines, liver and other organs protrude through the base of the umbilical cord

A

Omphalocele

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18
Q

A horseshoe kidney remains in the pelvic region due to obstruction of which artery

A

The inferior mesenteric artery

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19
Q

What syndrome is associated with bilateral aplasie of the kidneys and oligohydramios

A

Pott’s Syndrome

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20
Q

Oligohydramnios occurs when there is a reduction in what

A

Amniotic fluid

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21
Q

Autosomal dominant poly cystic kidney disease is often associated with what symptoms

A

Hypertension and uremia

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22
Q

What pathology can develop from remnants of primitive streak

A

Sacrococcygeal teratoma

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23
Q

Invagination of epiblast cells is associated with what major stage of embryonic development

A

Gastrulation

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24
Q

What is the name given for the period of pregnancy beginning from the first day of the last menstrual period to the estimated date of delivery

A

Gestation

25
Q

How is the embryonic age of a fetus is calculated

A

Gestational age less 2 weeks

26
Q

How is the gestational age calculated

A

40 weeks from the first day of the last menstrual period to the estimated date of delivery

27
Q

During fertilisation, the sperm passes through what structure to penetrate the zona pellucida

A

Corona radiata

28
Q

Cleavage begins approximately how many hours after fertilisation in the fallopian tube

A

30 hours

29
Q

During cleavage, the zygote goes through rapid Lito tic divisions resulting in a rapid increase in cell numbers called what

A

Blastomeres

30
Q

A morula is made up of a collection of approximately 30 of what type of cells

A

Blastomeres

31
Q

Day 4 of fertilisation is categorised by the development of what

A

Blastocyst

32
Q

A blastocyst has 3 main cellular layers

A
  1. Zona pellucida - trophoblast layer
  2. Inner cell mass
  3. Blastocoel cavity
33
Q

Trophoblast cells of the embryonic pole multiply and form what

A

Synchtiotrophoblast layer

34
Q

What 2 groups of cells does the inner cell mass of a blastocyst divide into

A

Epiblast and hypo last

35
Q

Which cells does the abembryonic pole consist of

A

Cytotrophoblast cells

36
Q

What are the 2 cavities that form in a blastocyst

A

Amniotic cavity and blastocyst cavity

37
Q

Complete implantation of the embryo into the endometrium is covered by what

A

A fibrin plug

38
Q

What are the diagnostic test available for confirmation of an ectopic pregnancy

A

Pregnancy test + Ultrasound

39
Q

What is the name given to a linear band of thickened epiblast that first appears at the caudal end of the embryo and grow cranially

A

The primitive streak

40
Q

The bilaminar layer is made up of what cells

A

The epiblast and hypoblast

41
Q

What is the name given to the layer when the epiblast cells move inward to form the intraembryonic mesoderm

A

Trilaminar layer

42
Q

Gastrulation occurs with the establishment of the trilaminar embryonic disc and formation of what 3 primary germ cell layers

A

1.Ectoderm
2. Mesoderm
3. Endoderm

43
Q

By the middle of week 3 the intraembryonic mesoderm separates what 2 germ layers

A

Ectoderm and endoderm

44
Q

The intraembryonic mesoderm separates the ectoderm and endoderm everywhere except….

A

The oropharyngeal membrane cranially
And
The cloacal membrane caudally

45
Q

What is the process that see cells migrating cranially through the primitive node which defines the primitive axis of the embryo

A

Notochordal process

46
Q

What is the name given to a cellular rod-like structure that defines the longitudinal axis and gives some rigidity

A

Notochord

47
Q

The notochord degenerate as the bodies of the vertebrae form but small portion of it persists in what structure of the vertebral disc

A

Nucleus pulposus

48
Q

The embryonic ectoderm gives rise to what tissues

A

Epidermis, nervous system, the eye, inner ear, neural crest cells

49
Q

The embryonic mesoderm gives rise to what tissues

A

Skeletal muscles, connective tissue, dermis, visceral smooth muscle, dérida of linings of body cavities, ducts and organs of the reproductive and excretory system, heart & CVS

50
Q

The embryonic endoderm gives rise to what tissues

A

Epithelial linings of respiratory & digestive tracts including glandular cells of liver and pancreas

51
Q

What is the name given to the process of the neural tube formation

A

Neurulation

52
Q

What does the neural plate give rise to

A

CNS - brain, spinal cord and retina

53
Q

What day does the closure of the neural tube occur

A

25th day

54
Q

What signifies the formation of the neural tube

A

When closure of caudal neuropore occurs

55
Q

Name the types of neural tube defects

A

Spina bifida occulta
Spina bifida cystica: meningocoele and meningomyelocoele
Rachischisis

56
Q

High levels of what in the amniotic fluid can indicate spina bifida

A

Alpha-fetoprotein - AFP

57
Q

How many weeks can the vertebrae be visualised to aid in detection of spinal defects

A

12 weeks gestation

58
Q

Name a syndrome that is an example of the failure of neural crest cells to migrate

A

Di-George Syndrome

59
Q

Name the 3 layers of the mesoderm

A
  1. Paraxial mesoderm
  2. Intermediate mesoderm
  3. Lateral Plate which is subdivided into somatic (parietal) and splanchnic (visceral)