Embryology and Pregnancy Flashcards
Finding of Low Alpha Fetoprotein in amniotic fluid
Down syndrome
What is derived from the 3rd and 4th laryngeal pouches
1) Thymus
2) Parathyroid glands
What is derived from Ratchkes pouch
Adenohypophysis
Component of pulomonary surfactant
Phosphatidylcholine (lecithin)
Used to measure the fetal lung maturity
Lecithin/sphingomyelin ration (L/S)
At what week should the L/S ratio be 2:1
35th week
What component from the mother exerts the greatest effect on the L/S ratio?
1) Cortisol
2) Cortisol has the greatest effect on increasing surfactant production
What is the processus vaginalis?
It is the invagination of the peritoneum that takes place when the testicles descend
What occurs when the processus vaginalis remains?
1) Persistent connection between scrotum and peritoneal cavity
What occurs in week 2 of early development of the fetus?
1) Development of the bilaminar disc
2) Consists of 2 layers (hypoblast and epiblast)
What occurs in week 3 of early development of the fetus?
1) Development of the trilaminar disc
2) Consists of 3 layers (Ectoderm, Mesoderm, and endoderm)
3) Gastrulation
Process that forms the trilaminar embryonic disc. Establishes the ectoderm, mesoderm, and endoderm germ layers
Gastrulation
How does gastrulation begin?
1) Invagination of the epiblast
2) Forms the primitive streak
What does the ectoderm consist of?
1) Surface ectoderm
2) Neuroectoderm (CNS)
3) Neural crest cells (PNS)
What does the mesoderm consist of?
1) Muscle
2) Bone
3) Cardiac
4) Renal
5) Vasculature
6) Adrenal cortex
7) Dermis
What does the endoderm consist of?
1) Gut tube epithelium
2) Luminal epithelium
What are the pharyngeal clefts derived from? Archs? Pouches?
1) Clefts = ectoderm
2) Arches = mesoderm
3) Pouches = endodermd
When does the heart begin to beat in the fetus?
Week 4
What does the first pharyngeal cleft develop into?
External auditory meatus
What does the 1st pharyngeal arch become?
Chew
1) Muscles for mastifiction
2) CN V2 and V3
3) Meckles cartilage (manible, malleus, incus, sphenomandibular ligament
What does the 2nd pharyngeal arch become?
Smile
1) Reichert’s cartilage: stapes, styloid process
2) CNVII
3) Muscles: muscles of facial expression
What does the 3rd pharyngeal arch become?
Stylishly swallow
1) Muscles: Stylopharyngeus
2) CN IX (glossopharyngeal nerve)
What does the 4th-6th pharyngeal arches become?
Simply swallow and speak
1) Cartilages: thyroid, cricoid, arytenoids
2) 4th = pharyngeal constrictors; 6th = intrinsic muscles of larynx
3) 4th = CN X, 6th = CN X
What do the pharyngeal pouches develop into?
Ear, Tonsil, Bottom to Top
1st pouch = middle ear cavity and eustachian tube
2nd pouch = epithelial lining of palatine tonsil
3rd pouch = inferior parathyroids and thymus
4th pouch = superior parathyroids
Agenesis of 3rd and 4th pharyngeal pouches?
Di George syndrome
1) Hypocalcemia
2) Immunosuppressed
3) Cardiac defects
What embryological structure develops into the female reproductive structures?
Paramesonephric (Mullerian) duct
How does male development occur in fetus?
1) Y chromosome carries the SRY gene which produces testis-determining factor
2) Sertoli cell secrete Mullerian inhibitory factor (MIF) that suppress the development of the paramesonephric duct
What secretes androgens to stimulate development of the mesonephric duct?
Leydig cells
What do Sertoli cells produce early on in development of a fetus sex?
Mullerian inhibitory factor
Describe the early development of the fetus from week 1 to 10
1) Week 1 = hCG secretion after implantation
2) Week 2 = bilaminar disc development
3) Week 3 = trilaminar disc development/gastrulation
4) Week 3-8 = Organogenesis; susceptible to teratogens
5) Week 4 = heart beats and limbs develop
6) Week 8 = fetal movment
7. Week 10 = genitalia have characteristics
When is the fetus most susceptible to teratogens?
3rd-8th week
What do the following teratogens do to the fetus?
1) ACE inhibitor
2) Alkylating agents
3) Aminoglycosides
4) Carbamazepine (anti-convulsant)
5) Diethylstilbestrol
6) Warfarin
7) Heparin
1) Renal damage
2) Absence of digits, multiple anomalies
3) CN VIII toxicity
4) Neural tube defects (spina bifida)
5) Vaginal Clear cell adenocarcinoma and T shaped uterine cavity
6) Stippled epiphyses and nasal hypoplasia
7) Prematurity and fetal demise
What do the following teratogens do to the fetus?
1) Folate antagonists
2) Lithium
3) Phenytoin and Diphenylhydantoin
4) Tetracylcine
5) Thalidomide
6) Lisinopril
7) Valproic acid
8) Retinoids (Isotretinoin or Etritinate)
1) Neural tube defect
2) Ebstein’s anomaly (atrialized right ventricle)
3) Fetal hydantoin syndrome
4) Discolored teeth
5) Limb defect (flippers)
6) Fetal mortality
7) Neural tube defect, cardiac, and skeletal abnormalities
8) Ear defects, blindness
What do the 1-4,6 aortic arch derivatives become?
1) 1= maxillary artery
2) 2 = Stapedial
3) 3 = Common Carotid and part of internal carotid
4) 4 = Right subclavian and Left part of aortic arch
5) 6 = Proximal part of pulmonary arteries and ductus arteriosus
What does the Wolffian duct make up?
SEED
1) Seminal vesicles
2) Epididymis
3) Ejaculatory duct
4) Ductus deferens
What is the triple marker screen?
1) alpha fetoprotein
2) hCG
3) Uncongugated estriol