Electrophysiology Flashcards
Volts generated by animals, such as electric eels or electric rays
700 volts
Volts in negative resting membrane potential
about -70 millivolts
Small variable changes in the membrane potential which are in the range of one to 40 millivolts.
Post-synaptic potentials
How are action potentials?
They are large, fast, and occur in an all-or-none fashion.
They reach 100 millivolts.
At rest, sodium-potassium exchanges use _____to alter the distribution of the ions across the membrane.
ATP
What similarity does electroplaques and neurons have?
They both have sodium-potassium exchanges in their plasma membrane
Volts in resting membrane potential
-60 and -80 millivolts inside the neuron
Which ions are inside the cell?
Chloride and sodium
Which neurotransmitter evoke electric discharge in electroplaques?
Acetylcholine
Number of sodium and potassium molecules exchanged in the Na+/K- ATPase
3 Na+ exit the cell and 2 K- enter the cell
Number of chloride and potassium molecules exchanged in the potassium chloride cotransporter
1 Cl- and 1 K- exit the cell
In Vmrest, which ions enter the cell by electrical gradient?
Ca+, K+ and Na+
In Vmrest, which ions enter the cell by concentration gradient?
Ca+, Cl- and Na+
In Vmrest, which ions exit the cell by electrical gradient?
Cl-
In Vmrest, which ions exit the cell by concentration gradient?
K+
Potentials generated by activation of ion channels that depolarize neurons
Excitatory postsynaptic potentials EPSP
Potentials generated by activation of ion channels that hyperpolarise neurons
Inhibitory postsynaptic potentials IPSP
Characteristics of EPSP and IPSP
Graded in amplitud due to concentration of neurotransmitter and length of the time the neurotransmitter is in the synaptic cleft
Additive but decay in amplitud as they move around the neuron
Name state of Na channels in each stage of the curve of the action potential stages
Resting Vm. Closed resting
Upstroke. Open
Peak. Closed inactivating
Downstroke. Closed inactivated
Resting Vm Close resting
Name state of Na channels in each stage of the curve of the action potential stages
Resting Vm. Closed resting
Upstroke. Closed resting
Peak. Start opening
Downstroke. Open
Resting Vm Close resting
Which types of potentials can be recorded from outside the cell?
Excitatory potentials and action potentials
Which type of potentials can be generated by neurotransmitter ion channel receptors ?
Excitatory potentials and postsynaptic potentials
Which type of potential can be generated by voltage gated ion channels ?
Action potentials
Types of electrophysiologic recording
Extra cellular
Intracelular
Single channel recording
