electron transport chain Flashcards
what the final electron acceptor in the electron acceptor chain
Oxygen. It then gets protonated and splits into two H2O molecules
Which complex in ETC cannot get supercharged?
Complex II
Which prosthetic group receives electrons from 2 different complexes?
Coenzyme Q or ubiquinone.
It receives NADH from complex 1 and FAD from complex 2
Complex 1 called?
NADH coenzyme Q reductase or NADH dehydrogenase
Complex 2 called?
Succinate coenzyme Q reductase or succinate dehydrogenase
Complex 3 called?
Coenzyme Q reductase or cytochrome bc 1 complex
Complex 4 called?
Cytochrome C oxidase
Where does the ETC take place?
Inner mitochondrial membrane
Where does the fatty acid oxidation pathway take place?
Mitochondrial matrix
Where does the citric acid cycle take place?
Mitochondrial matrix
Where does glycolysis take place?
Cytoplasm
Which pathway is the major source of ATP in the cell?
Oxidative phosphorylation
The electron transport chain/ respiratory chain catalyses the transport of electrons from — to —? Why is this reaction highly exergonic?
From NADH+H+ (reduced ubiquinone QH2) to oxygen molecule. Highly exergonic due to difference in redox potentials.
TRUE OR FALSE: The electrons in ETC are transferred from high potential to lower potential
True.
Which complex uses electrons and H ions to reduce molecular oxygen to water
Complex IV (Cytochrome C oxidase)
What is the inner mitochondrial membrane impermeable to?
H+, Na+, K+ & small molecules (ATP, ADP)
What is marked as Site I of the ETC?
From NADH
to ubiquinone or coenzyme Q
What is marked as site II of the ETC
From Complex III (Coenzyme Q reductase or cytochrome bc1)
To cytochrome C
What is marked as site III of ETC?
From cytochrome c
To O2
What are the 2 types of uncoupling agents? Give examples.
- Synthetic : 2,4-Dinitrophenol, valinomycin, gramicidin
- Physiological: Thryoxin, Thermogenins (found in brown adipose tissue)
What are the ways for suppression of ATP production in ETC & OP
- Uncoupling of oxidation & phosphorylation
- Inhibition of transfer of electrons
Site 1 electron transport inhibitors
Rotenone (fish poison & insecticide)
Alkylguanines (hypotensive drug)
Barbiturates
Actinomycin
Site 2 electron inhibitors
Napthoquinone
Site 3 electron inhibitors
CO, CN, H2S
