electron transport chain Flashcards

1
Q

what the final electron acceptor in the electron acceptor chain

A

Oxygen. It then gets protonated and splits into two H2O molecules

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2
Q

Which complex in ETC cannot get supercharged?

A

Complex II

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3
Q

Which prosthetic group receives electrons from 2 different complexes?

A

Coenzyme Q or ubiquinone.
It receives NADH from complex 1 and FAD from complex 2

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4
Q

Complex 1 called?

A

NADH coenzyme Q reductase or NADH dehydrogenase

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5
Q

Complex 2 called?

A

Succinate coenzyme Q reductase or succinate dehydrogenase

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6
Q

Complex 3 called?

A

Coenzyme Q reductase or cytochrome bc 1 complex

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7
Q

Complex 4 called?

A

Cytochrome C oxidase

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8
Q

Where does the ETC take place?

A

Inner mitochondrial membrane

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9
Q

Where does the fatty acid oxidation pathway take place?

A

Mitochondrial matrix

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10
Q

Where does the citric acid cycle take place?

A

Mitochondrial matrix

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11
Q

Where does glycolysis take place?

A

Cytoplasm

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12
Q

Which pathway is the major source of ATP in the cell?

A

Oxidative phosphorylation

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13
Q

The electron transport chain/ respiratory chain catalyses the transport of electrons from — to —? Why is this reaction highly exergonic?

A

From NADH+H+ (reduced ubiquinone QH2) to oxygen molecule. Highly exergonic due to difference in redox potentials.

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14
Q

TRUE OR FALSE: The electrons in ETC are transferred from high potential to lower potential

A

True.

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15
Q

Which complex uses electrons and H ions to reduce molecular oxygen to water

A

Complex IV (Cytochrome C oxidase)

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16
Q

What is the inner mitochondrial membrane impermeable to?

A

H+, Na+, K+ & small molecules (ATP, ADP)

17
Q

What is marked as Site I of the ETC?

A

From NADH
to ubiquinone or coenzyme Q

18
Q

What is marked as site II of the ETC

A

From Complex III (Coenzyme Q reductase or cytochrome bc1)
To cytochrome C

19
Q

What is marked as site III of ETC?

A

From cytochrome c
To O2

20
Q

What are the 2 types of uncoupling agents? Give examples.

A
  1. Synthetic : 2,4-Dinitrophenol, valinomycin, gramicidin
  2. Physiological: Thryoxin, Thermogenins (found in brown adipose tissue)
21
Q

What are the ways for suppression of ATP production in ETC & OP

A
  1. Uncoupling of oxidation & phosphorylation
  2. Inhibition of transfer of electrons
22
Q

Site 1 electron transport inhibitors

A

Rotenone (fish poison & insecticide)
Alkylguanines (hypotensive drug)
Barbiturates
Actinomycin

23
Q

Site 2 electron inhibitors

A

Napthoquinone

24
Q

Site 3 electron inhibitors

A

CO, CN, H2S