Electroclinical syndromes-intro and neonatal syndromes

Question 1

Neonatal Period

Answer 1

• Benign familial neonatal epilepsy
• Early myoclonic encephalopathy
• Ohtahara syndrome

Question 2

Infancy

Answer 2

• Epilepsy of infancy with migrating focal seizures
• West syndrome
• Myoclonic epilepsy in infancy
• Benign infantile epilepsy
• Benign familial infantile epilepsy
• Dravet syndrome
• Myoclonic encephalopathy in nonprogressive disorders

Question 3

Childhood

Answer 3

• Febrile seizures plus (can start in infancy)
• Panayiotopoulos syndrome
• Epilepsy with myoclonic atonic seizures
• Self-limiting epilepsy with centrotemporal spikes
• Autosomal dominant nocturnal frontal lobe epilepsy
• Late-onset childhood occipital epilepsy (Gastaut type)
• Epilepsy with myoclonic absences
• Lennox-Gastaut syndrome
• Epileptic encephalopathy with continuous spike-and-wave during sleep
• Landau-Kleffner syndrome
• Childhood absence epilepsy

Question 4

Adolescence to Adulthood

Answer 4

• Juvenile absence epilepsy
• Juvenile Myoclonic epilepsy
• Epilepsy with generalized tonic-clonic seizures alone
• Progressive myoclonic epilepsies
• Autosomal dominant epilepsy with auditory features
• Other familial temporal love epilepsies

Question 5

Early Myoclonic Encephalopathy

Answer 5

• focal myoclonia of face or extremities
• migration from one body part to another
• unremitting burst-suppression pattern, prominent during sleep
• can develop into West syndrome and LGS

Question 6

Ohtahara syndrome (EIEE)

Answer 6

• tonic seizures, hemi-clonic seizures
• Structural>metabolic
• Burst-suppression pattern EEG

Question 7

Benign Neonatal seizures (fifth-day fits)

Answer 7

• unifocal clonic

- EEG: theta pointu alternant

Question 8

Benign Familial Neonatal Epilepsy

Answer 8

• Autosomal Dominant (KCNQ1 and KCNQ2)
• positive family history
• seizure: hypertonia, spasms, facial movements, clonus