Electrical Stimulation for Tissue Healing Flashcards
What percentage of individuals with previous healed diabetic foot ulcer will have:
Reoccurrence within 1 year?
Recurrence within 3 yr?
Reccurence within 5 yrs?
40%
60%
65%
Of those who suffer an amputation as a result of chronic wounds, what percent will undergo a second procedure? And what percent will die within 1 month? What percent will die within 1 year?
25%
22%
44%
What causes mortality to be 2x higher in diabetics?
Foot Ulcer
Who is more likely to undergo an amputation? Diabetic or Not one?
Diabetic (8x more)
How do chronic wounds form? (Etiology)
Decreased Sensation
Decreased Blood Supply
Decreased ROM
Decreased Mobility
How can you facilitate tissue healing with electricity?
Directly or indircetly
What is indirectly applying electricity do?
Control edema
Transdermal delivery of medication
What are some mechanism of electrical stimulation & tissue healing?
Galvanotaxis
Cell Activation
Antimicrobial Effects
Enhanced Circulation
What is Galvanotaxis?
Directional movement of cells in response to electrical field
How does Galvanotaxis cause tissue healing?
Alter cell membrane function
Enhance Antimicrobial Activity
Promote Circulation
Reduce Edema
Improve Tissue Oxygenation
Biologically what happens following the wound at the skin?
- Trans epithelial potential becomes 0 at wound & the intact skin has higher trans epithelial potential
- This generates a weak electrical field that pushes current to center of wound
- Electrical field keeps going until there is new epithelial on the wound
Why when there is a wound does epithelial cells get driven toward the center of the wound?
The electrical field provides a directional signal to guide migrating epithelial cells toward wound center
What charge do you apply to a wound to stimulate healing?
Cathode (Negative)
What will using a cathode bring to the wound?
Lymphocytes
Platelets
Mast Cells
Keratinocytes
Neural progenitor cells
Fibroblasts
Activate neutrophils
What charge do you apply to aid in sealing the wound up?
Anode (pos)
What does using an anode bring to the wound?
Macrophages
Epidermal Cells
Inactive Neutrophils
What two things can cellular activation do to stimulate tissue healing?
- Electrical Stimulation activates fibroblasts
- Promote epidermal & lymphocyte migration, proliferation & function
How does activating fibroblast help promote tissue healing?
Enhance replication & synthesis of DNA & collagen
Upregulating growth factor pathways
Induces conversion to myofibroblasts
What does the promotion of epidermal & lymphocyte migration, proliferation & function cause? And how does that help tissue healing?
Increases Vascular Endothelial Growth Factor production
This stimulated development of microcirculation which increases delivery of O2 & nutrients
When discussing the antimicrobial effects of electrical stimulation & tissue healing what does Monophonic Currents do?
Kill bacteria
May be effective against antibiotic resistant bacteria in biofilms by enhancing other agents (Silver Dressing)