Eicosanoids II

Question 1

IV administration of PGE2 or PGI2 causes what effect on blood pressure
-what receptors are acted on

Answer 1

causes a fall in BP

-d/t EP2/EP4 recetpro activity

Question 2

What affect does PGE2 and PGI2 : vasoD or VasoC

Answer 2

VasoD

Question 3

What effected does TXA2 and PGF2-alpha have on CV or VSM?

Answer 3

Vacosonctricion

–sometimes PGE2 is vasoC when acting on EP1 or EP3 (otherwise is a vasodialator)

Question 4

For CV and VSM, PGD2 is a _______ except in pulmonary circulation where it is a _______

Answer 4

vasoD

vasoC

Question 5

Locally produced PGs tend to dominate and this effect

Answer 5

VasoDIALATION

Question 6

Circulating autocoids like angiotensin II are couteracted by:

Answer 6

locally produced PGs that push for vasodialation

–key to maintaining blood flow to vital organs, especially the kidney

Question 7

The ductus arteriosis patency is maintained during fetal life by:

Answer 7

PGs

Question 8

The ductus areteriosis allows most of the blood leaving the RV to:

Answer 8

bypass lungs and go right into descending aorta

Question 9

The main PG to maintain the ductus arteriosis during fetal life is:

Answer 9

PGE2 via the EP4 receptor

–made by COX-2

Question 10

the main source of PGE2 in fetus is:

Answer 10

placenta which is lost after deliver thus we see decrease PGE2 and increased pulmonary blood flow