Eicosanoids Flashcards

1
Q

PGD2 receptors and IC molecule

A

DP1 and DP2, cAMP

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2
Q

PGI2 receptors and IC molecule

A

IP, cAMP

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3
Q

PGF2a receptors and IC molecule

A

Fp, Ca2+

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4
Q

PGE2 receptors and IC molecule

A

EP1/3 –Ca2+

EP2/4 cAMP (3 can also do

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5
Q

TXA2 receptors and IC molecule

A

TP, Ca2+

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6
Q

Which two PGs lower pain threshold and increase renal BF?

A

PGE2 and PGI2

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7
Q

What are the effects of PGD2?

A

inhibits platelet aggregation, vasodilator e/c in broncho smooth muscle

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8
Q

What are the effects of PGI2 (4) produced by? effect in pregnancy?

A
lower pain threshold
vasodilator (relaxation of smooth muscle
stops platelet aggregation
Increases renal BF
produced by endothelial cells

keeps uterus quiet during early pregnancy

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9
Q

What PG is a bronchoconstrictor and responsible for myometrial contraction?

A

PGF2 (bc Ca2+)

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10
Q

Effects of PGE2? (5) uterus effects?

A
hyperalgesia
fever (through HPT)
vasodilator
Increases renal BF
Gi effects
EP1/3- contract uterus
EP2/4-cervical ripening, EP4 keeps DA dilated
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11
Q

Which PGs inhibit acid secretion in GI?

A

PGE2 (EP3) and PGI2 (IP)

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12
Q

Which PGs increase gastric mucous blood flow?

A

PGE2 (2/4) and PGI2

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13
Q

Other PGE2 GI effects? (3)

A

stimulates release of viscous mucosa, bicarb secretion, contracts GI smooth muscle (ep1)

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14
Q

Which Cox enzyme for GI protective effects?

A

COX 1

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15
Q

Dinoprostone-what PG analog? 2 uses

A

PGE2

cervical ripening in pregnancy and termination of early pregnancy

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16
Q

3 main adverse effects of Dinoprostone, Carboprost?

A

GI related, fever, uterine rupture

17
Q

Carboprost-what PG analog? 2 uses

A

PGF2a

termination of early pregnancy, control post partum hemorrhage

18
Q

Misoprostol what PG analog? major use

A

PGE1 - EP3, 2/4
prevention of ulcers caused by long term administration of NSAIDs

CI in pregnancy, diarrhea main side effect

19
Q

Alprostadil what PG analog? 2 uses. what receptor?

A

PGE1
impotence/ED and temp maintenance of PDA until surgery
EP 2/4

20
Q

Epoprostenol what PG analog? main use and mech

A

PGI2
primary pulmonary hypertension
camp mediated dilation of pulmonary artery vascular smooth muscle

21
Q

Bimatoprost what PG analog? 2 uses

A

Glaucoma and eyelash hypotrichosis

increases outflow of aqueous humor-EP2/4