Eicosanoids Flashcards
PGD2 receptors and IC molecule
DP1 and DP2, cAMP
PGI2 receptors and IC molecule
IP, cAMP
PGF2a receptors and IC molecule
Fp, Ca2+
PGE2 receptors and IC molecule
EP1/3 –Ca2+
EP2/4 cAMP (3 can also do
TXA2 receptors and IC molecule
TP, Ca2+
Which two PGs lower pain threshold and increase renal BF?
PGE2 and PGI2
What are the effects of PGD2?
inhibits platelet aggregation, vasodilator e/c in broncho smooth muscle
What are the effects of PGI2 (4) produced by? effect in pregnancy?
lower pain threshold vasodilator (relaxation of smooth muscle stops platelet aggregation Increases renal BF produced by endothelial cells
keeps uterus quiet during early pregnancy
What PG is a bronchoconstrictor and responsible for myometrial contraction?
PGF2 (bc Ca2+)
Effects of PGE2? (5) uterus effects?
hyperalgesia fever (through HPT) vasodilator Increases renal BF Gi effects EP1/3- contract uterus EP2/4-cervical ripening, EP4 keeps DA dilated
Which PGs inhibit acid secretion in GI?
PGE2 (EP3) and PGI2 (IP)
Which PGs increase gastric mucous blood flow?
PGE2 (2/4) and PGI2
Other PGE2 GI effects? (3)
stimulates release of viscous mucosa, bicarb secretion, contracts GI smooth muscle (ep1)
Which Cox enzyme for GI protective effects?
COX 1
Dinoprostone-what PG analog? 2 uses
PGE2
cervical ripening in pregnancy and termination of early pregnancy
3 main adverse effects of Dinoprostone, Carboprost?
GI related, fever, uterine rupture
Carboprost-what PG analog? 2 uses
PGF2a
termination of early pregnancy, control post partum hemorrhage
Misoprostol what PG analog? major use
PGE1 - EP3, 2/4
prevention of ulcers caused by long term administration of NSAIDs
CI in pregnancy, diarrhea main side effect
Alprostadil what PG analog? 2 uses. what receptor?
PGE1
impotence/ED and temp maintenance of PDA until surgery
EP 2/4
Epoprostenol what PG analog? main use and mech
PGI2
primary pulmonary hypertension
camp mediated dilation of pulmonary artery vascular smooth muscle
Bimatoprost what PG analog? 2 uses
Glaucoma and eyelash hypotrichosis
increases outflow of aqueous humor-EP2/4
