Eicosanoids Flashcards
What does Montelukast inhibit?
Inh. Leukotriene LTD4 used for chronic asthma, not acute attacks
What does Zafirlukast inhibit?
Leukotriene
What does Zileuton inhibit?
Inh. 5-lipoxygenase used for chronic asthma
Explain prostaglandins and GI mucosa.
PGs, esp PGE2, increase blood flow to GI mucosa
Explain PGs and Stomach acid.
Cox-1»_space; PGE2 and PGI2»_space; inhibit proton pumps
NSAIDs inhibit Cox-1»_space; increase acid
NSAIDs + PPI might be necessary
PGs and platelets
Cox-1 in PLT membrane»_space; TxA2»_space; clotting
ASA irreversibly binds Cox-1
NSAIDs reversibly bind Cox-1
In Renal…
Cox-1
Cox-2
COX1 controls renal hemodynamics and GFR
COX2 controls Na and water retention
In Renal Cox inhibitors do what?
Inh COX ⇒ ↓PGE2 ⇒ Na retention ⇒ ↑ BP ⇒ dec. Aldo ⇒ cause hyper K
Inhb COX ⇒ ↓PGI2 ⇒ hyperKemia and ARF
What are the baseline and inflammatory levels of
Cox-1
Cox-2
Cox-1 is constituitive
Cox-2 is increased during inflammation
In terms of Cox, what do each do?
glucocorticoids
NSAIDs
GC»_space; inhibit synthesis of cox-2
NSAIDs»_space; inhibit activity of Cox
What is Misoprostol? (also alprostadil)
PGE1 analog that inhibits gastric acid secretion, increases HCO3 and mucus in stomach and is an abortifacient
What is Aloprostadil?
PGE1 analog that is used for patent ductus arteriosus and erectile dysfunction in pt that do not respond to sildenafil
What is Epoprostenol? (also liloprost)
PGI2 analog used in pulmonary HT
What is Latanoprost?
PGF2-alpha analog used in glaucoma
What is Zafirlukast?
Leukotriene R antagonist used for asthma
