Eicosanoids Flashcards
Arachidonic acid is omega ___?
Omega 6
Arachidonic acid is derived by _______ & ________ of linoleic acid
Elongation and Desaturation
PGI2 is unstable and is converted to _____ to become stable
6-oxo-PGF1 alpha
TXA2 is unstable and is converted to _____ to become stable
TXB2
PIP2 stands for
Phosphatidylinositol 4,5-bisphosphate
DAG kinase on DAG yields what ?
Phosphatidic acid
Phospholipase A2 on phosphatidic acid yields ____?
Lysophosphatidic acid
Arachidonic acid
Year of origin of prostaglandin & By who? & Used what??
1930
Ulf von Euler
Human semen extract
Prostaglandins are made by all cells except ____
RBC
PGE was isolated from body fluids in _____ extract in what year?
Ether
Mid 50s
Arachidonic acid is phospholipid bound at what position?
Sn2
PGH synthase is what type of membrane protein?
Give another example of it
Monotopic membrane protein
Squalene hopene Cyclase
PGH synthase contains _________ radical. This is labeled as number _____. This radical is activated by ____
Tyrosine
Tyr385
Heme
PGH synthase is a _________ monotopic _____ protein
Homodimeric monotopic ER membrane protein
The active side of PGHS is in the _____
Tyr
Aspirin acetylates _______
Serine 530
Platelets have ___ days lifetime and hence can not resynthesize the enzyme
10
COX 3 may be the target of _________, which is a ____&_____ drug
Acetaminophen
Analgesic and Antipyretic
Vioxx is also called ____
Rofecoxib
Celecoxib is also called _____
Celebrex
The Eskimos have a low risk of CVS disease despite that they eat lots of fat. Why?
This is cos they consume more of omega 3 polyunsaturated fatty acids (like fish oil, canola oil & walnuts).
They do not consume omega 6 polyunsaturated fatty acids (like sunflower oil & corn oil).
