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BCH 204 > Eicosanoids > Flashcards

Eicosanoids Flashcards

1
Q

Arachidonic acid is omega ___?

A

Omega 6

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2
Q

Arachidonic acid is derived by _______ & ________ of linoleic acid

A

Elongation and Desaturation

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3
Q

PGI2 is unstable and is converted to _____ to become stable

A

6-oxo-PGF1 alpha

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4
Q

TXA2 is unstable and is converted to _____ to become stable

A

TXB2

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5
Q

PIP2 stands for

A

Phosphatidylinositol 4,5-bisphosphate

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6
Q

DAG kinase on DAG yields what ?

A

Phosphatidic acid

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7
Q

Phospholipase A2 on phosphatidic acid yields ____?

A

Lysophosphatidic acid

Arachidonic acid

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8
Q 
Year of origin of prostaglandin 
&
By who?
&
Used what??
A

1930
Ulf von Euler
Human semen extract

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9
Q

Prostaglandins are made by all cells except ____

A

RBC

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10
Q

PGE was isolated from body fluids in _____ extract in what year?

A

Ether

Mid 50s

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11
Q

Arachidonic acid is phospholipid bound at what position?

A

Sn2

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12
Q

PGH synthase is what type of membrane protein?

Give another example of it

A

Monotopic membrane protein

Squalene hopene Cyclase

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13
Q

PGH synthase contains _________ radical. This is labeled as number _____. This radical is activated by ____

A

Tyrosine
Tyr385
Heme

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14
Q

PGH synthase is a _________ monotopic _____ protein

A

Homodimeric monotopic ER membrane protein

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15
Q

The active side of PGHS is in the _____

A

Tyr

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16
Q

Aspirin acetylates _______

A

Serine 530

17
Q

Platelets have ___ days lifetime and hence can not resynthesize the enzyme

A

10

18
Q

COX 3 may be the target of _________, which is a ____&_____ drug

A

Acetaminophen

Analgesic and Antipyretic

19
Q

Vioxx is also called ____

A

Rofecoxib

20
Q

Celecoxib is also called _____

A

Celebrex

21
Q

The Eskimos have a low risk of CVS disease despite that they eat lots of fat. Why?

A

This is cos they consume more of omega 3 polyunsaturated fatty acids (like fish oil, canola oil & walnuts).
They do not consume omega 6 polyunsaturated fatty acids (like sunflower oil & corn oil).

BCH 204 (1 decks)

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