EH - Psychiatry Flashcards
Timing criteria for schizophrenia?
6+ months; Any symptoms (negative)
Timing criteria for schizophreniform disease?
1-6 months
Prevalence of schizophrenia?
0.5 – 1.0%
Risk for schizophrenia in twin brother?
50%
Risk for schizophrenia in sibling?
10%
Origin of (+) symptoms in schizophrenia?
Excess dopamine in mesolimbic tract
Origin of (–) symptoms in schizophrenia?
Deficient dopamine in mesocortical tract
Patient presents with delusions, hallucinations, flattened affect for past 3 weeks – diagnosis?
Brief psychotic disorder
Timing criteria for Brief psychotic disorder?
Between 1 week and 1 month
Best treatment for Brief psychotic disorder?
1st generation antipsychotics
Benefit of 1st generation antipsychotics in treatment of schizophreniform disease and Brief psychotic disorder?
Alleviates (+) symptoms; Does not alter course of disease
Pt presents with 3 years of persecutory delusions; 6 months ago began experiencing increased guilt, sleep disturbance, sadness, SI – diagnosis?
Schizoaffective disease … psychotic symptoms are present in the absence of depression
Best treatment for Schizoaffective disease?
Antipsychotic + Antidepressant
Treatment for psychotic depression?
ECT
Patient is convinced that celebrity is in love with him; Otherwise functional in daily life – diagnosis?
Delusional disorder
MOA of haloperidol?
Inhibits D2 dopamine receptor
2 AEs of haloperidol?
Galactorrhea, Extra-pyramidal symptoms
What accounts for galactorrhea in setting of haloperidol use?
Inhibition of dopamine release in tubuloinfundibular tract
What accounts for extra-pyramidal symptoms in setting of haloperidol use?
Inhibition of dopamine release in nigrostriatal tract
High potency anti-psychotics?
Haloperidol, Fluphenazine
Low potency anti-psychotics?
Chlorpromazine, Thioridazine, Levomepromazine
AE of low potency anti-psychotics?
Greater anticholinergic AEs
Benefit of low potency anti-psychotics?
Fewer extra-pyramidal symptoms
Which medication is responsible for purple-grey metallic rash over sun-exposed skin + jaundice?
Chlorpromazine
… (colorful)
Which medication is responsible for prolonged QTC and pigmented retinopathy?
Thioridazine
Best treatment for dystonic reactions in setting of antipsychotic medications?
Benztropine, Diphenhydramine
Best treatment for akanthasia in setting of antipsychotic medications?
Benzodiazepine, Propranolol
Best treatment for Parkinsonian features in setting of antipsychotic medications?
Benztropine, Diphenhydramine
Best treatment for tardive dyskinesia in setting of antipsychotic medications?
No treatment … need to discontinue anti-psychotic
2 other DOCs used to treat Neuroleptic Malignant Syndrome (not dantrolene)?
Bromocriptine, Metoclopramide
Which atypical anti-psychotic has highest risk of EPS and galactorrhea?
Risperidone
Which anti-psychotic is weight-neutral, but prolongs QTC?
Ziprasidone
Which anti-psychotic is weight-neutral, but causes akanthasia?
Aripiprazole
Which 2 anti-psychotics are weight-neutral?
Ziprasidone, Aripiprazole
Which atypical anti-psychotic causes weight gain?
Olanzapine
… Olanzapine = Obesity
Which atypical anti-psychotic causes Orthostasis?
Quetiapine
… (you’re quiet when you faint)
Why does quetiapine cause orthostasis?
Blocks alpha-1 receptors
Which atypical anti-psychotic is effective for treatment of refractory schizophrenia?
Clozapine
Most common AE of Clozapine?
Weight gain, sedation, Metabolic syndrome
Most dangerous AE of Clozapine?
Agranulocytosis, Seizures
Timing criteria for major depressive disorder?
2 weeks
Most important risk factor for suicide?
Prior attempt
Change to sleep in setting of MDD?
Decreased stage ¾ sleep, Shortened REM latency, More frequent REM
Atypical lab test in patients with MDD?
Cortisol … unaffected by dexamethasone suppression test
3 medications that may lead to depression?
B blockers, IFN-gamma, alpha methyldopa
Which type of CVA can cause depression?
L MCA
Which SSRI has most drug-drug interactions?
Paroxetine … CYP450
(Paroxetine works in Pairs)
Which SSRI does not require tapering?
Fluoxetine
Fluoxetine 1/2 life = Forever
Why does fluoxetine not require tapering?
Longest half life
Which SSRI has fewest drug-drug interactions?
Citalopram
Citalopram … sits by itself
Which SSRI is most likely to cause Serotonin Discontinuation Syndrome if stopped suddenly?
Sertraline
Clinical presentation of Serotonin Discontinuation Syndrome?
Flu-like symptoms
Which anti-depressant is indicated for patient who experiences sexual dysfunction while taking SSRI?
Bupropion
MOA of Bupropion?
Inhibition of NET and DAT
CI to Bupropion?
Seizures, ETOH abuse, Bulimia
Which anti-depressant should be avoided in HTN patients?
Venlafaxine
SNRIs + ___ may result in HTN crisis?
St. John’s Wort
Best treatment for HTN crisis in patients taking MAOI?
Alpha blocker
Young male eats pills from grandmother’s purse; Develops dry mouth, tachycardia, seizures, urinary retention; EKG shows widened QRS complexes and prolonged QT interval – which medication did the patient ingest?
TCA
Best treatment for TCA overdose?
Sodium bicarbonate
Patient with signs of MDD also experiences leaden paralysis in AM – diagnosis?
Atypical depression
2 other symptoms of Atypical depression?
Increased sleep, increased appetite
DOC for Atypical depression?
MAOIs
2 clinical symptoms of complicated bereavement?
Psychosis, Suicidal thoughts
Timing criteria for adjustment disorder?
Must begin within 3 months of stressor; Can’t last longer than 6 months of stressor
Best treatment for adjustment disorder?
Psychotherapy
Incidence of Bipolar Disorder in general population?
1%
Risk for Bipolar Disorder in identical twin?
90%
Which type of CVA may result in symptoms of mania?
R MCA
Which medications should be avoided in patients with Bipolar Disorder?
SSRIs, TCA
3 DOCs for Bipolar Disorder?
Lithium, Valproic Acid, Carbamazepine
DOC for agitation in patient with Bipolar Disorder?
Haloperidol
Pt with PMHX of bipolar disorder presents with NVD, coarse tremor, ataxia, slurred speech – diagnosis?
Lithium toxicity
Which class of medications are notorious for precipitating Lithium toxicity?
NSAIDs
Which 2 NSAIDs are least likely to precipitate Lithium toxicity?
ASA, Sulendac
2 EKG findings associated with Lithium toxicity?
Flattened T waves, U waves
… (EKG does down)
Best treatment for Lithium overdose?
Dialysis
Major AEs of Lithium?
Nephrogenic DI, GI upset, Hypothyroidism
MOA of Lithium?
Inhibition of inostotrol triphosphate
Which lab tests are essential for monitoring of Lithium?
Renal function, Thyroid function
CI to use of Lithium?
CKD (precipitates toxicity due to inability to clear Lithium renally), Pregnancy
Problems that Lithium causes during pregnancy?
Epstein Syndrome … atrialization of RV