EGFR targets

Question 1

Osemertinib

Answer 1

EGFR

Question 2

Alectinib and Brigatinib
Al and Bridget nibble on elk

Answer 2

ALK

Question 3

Crosotinib and Intrectinib
Crosby goes into meet ROS first time

Answer 3

ROS 1

Question 4

Supracatinib
Supercat attaches to RET Butler’s leg

Answer 4

RET fusions

Question 5

Entrectinib and Laratrectinib
Lara Enters into fusions

Answer 5

Entrect fusions

Question 6

Catatanib

Answer 6

Med Exon 14 skipping mutation

Question 7

Dabrafenib and tremectinib

Answer 7

BRAF mutated

Question 8

Anaplastic lymphoma kinase
MOA

Answer 8

INH ALK phosphorylation and ALK mediated acctivation of downstream signaling and expression = decreased cell proliferation and tumor cell survival

Question 9

EGFR INH

WHO are
Afat EArl Jefit Osimmer

Answer 9

Afatinib Erlotinib Geftinib Osimertinib

Question 10

BCR-ABL INH

Answer 10

Philadelphia chromosome + CML

Question 11

SE of crizotinib

Answer 11

N&V diarrhea constipation fatigue increased liver enzymes, fatigue, vision disturbances, QT prolongation bradycardia, hyperglycemia

Question 12

BRAF Inhibitors

Answer 12

BRAF-V600E- mutated melanoma
AND NSCLC

Question 13

BRAF MOA

Answer 13

Selctively inhibits some mutated forms of protein kinase BRAF: and INHIBITS tumor cell growth.

Question 14

BCR-ABL INHIbitors

Answer 14

TINIB Bosutinib Dasatinib. Imatinib. Niltinib. Ponatinib

Question 15

BCR-ABL INH MOA

Answer 15

Binds site on BCR-ABL TKI ATP binding domain

Question 16

BRAF INH SE

Answer 16

Papilloma, arthralgia alopecia fatigue HA. palmer-plantar erythrodysesthesia (Hand/Foot Syndrome) pyrexia