****Effects of Drugs used in CHF**** Flashcards

1
Q
What is the Effect of Digoxin on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Increased Inotropy
  • Natriuretic
  • Increased Survival
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2
Q
What is the Effect of Milrinone on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Afterload
  • Increased Inotropy
  • Natriuretic
  • Decreased Survival ?
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3
Q
What is the Effect Furosemide of on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • Natriuretic
  • NO effect on survival
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4
Q
What is the Effect of Hyrdalazine on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Afterload
  • Decreased Natriuresis
  • Increased Survival
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5
Q
What is the Effect of Nitrates on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • No effect on natriuresis
  • No effect on survival
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6
Q
What is the Effect of ACE-I on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • Decreased Afterload
  • Anti-mitogenic
  • Increased Natriuresis
  • Increased Survival
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7
Q
What is the Effect of ARB on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • Decreased Afterload
  • Anti-mitogenic
  • Increased Natriuresis
  • Increased Survival
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8
Q
What is the Effect of Spinronolactone on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • Anti-mitogenic
  • Increased Natriuresis
  • Increased Survival

***Why no decrease in afterload?

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9
Q
What is the Effect of Dobutamine on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased or Increased (based on alpha effects?)
  • Increased Inotropy
  • Natriuretic
  • No effect on survival
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10
Q
What is the Effect of Nesiritide on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased Preload
  • Decreased Afterload
  • Antimitogenic
  • Natriuretic
  • unknown effect on survival
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11
Q
What is the Effect of Beta-blockers on: 
• Preload
• Afterload
• Inotropy 
• Anti-mitogenic 
• Natriuretic 
• Survival Benefit
A
  • Decreased then increased intropy
  • Anti-mitogenic
  • Natriuretic
  • Increased survival
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