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Immunology > Effector T Helper Subsets & Cytokine Ab Isotypes > Flashcards

Effector T Helper Subsets & Cytokine Ab Isotypes Flashcards

1
Q

Polarizing cytokines Th1

A

IL-12, IFN-gamma, and IL-18

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2
Q

Master Transcriptional Regulator Th1

A

T-Bet

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3
Q

Effector cytokines Th1

A

IFN-gamma and TNF-alpha

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4
Q

Effector function Th1

A

Combats intracellular pathogens and activates macrophages.

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5
Q

Role in disease Th1

A

Tissue inflammation

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6
Q

Polarizing cytokines Th2

A

IL-4

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7
Q

Master Transcriptional regulator Th2

A

GATA3

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8
Q

Effector cytokines Th2

A

IL-4, IL-5, and IL-13

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9
Q

Effector functions Th2

A

Combats helminth (worm) infection, activates eosinophils.

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10
Q

Role in disease Th2

A

Allergy

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11
Q

Polarizing cytokines Th17

A

IL-23, IL-6, and TGF-Beta

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12
Q

Master transcriptional regulator Th17

A

RORyt

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13
Q

Effector cytokines Th17

A

IL-17 and IL-22

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14
Q

Effector function Th17

A

Combats extracellular pathogens FUNGAL

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15
Q

Role in disease Th17

A

Autoimmunity

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16
Q

Polarizing cytokines ThREG

A

IL-2, TGF-Beta

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17
Q

Master transcriptional regulator Threg

A

FoxP3

18
Q

Effector cytokines Threg

A

IL-10 and TGF-Beta

19
Q

Effector function Threg

A

Suppresses immune responses

20
Q

Role in disease Threg

A

Inhibits anti tumor response

21
Q

Polarizing cytokines Thfh

A

IL-6 and IL-21

22
Q

Master transcriptional regulator Thfh

A

Bcl-6

23
Q

Effector cytokines Thfh

A

IL-4 and IL-21

24
Q

Effector function Thfh

A

Regulates affinity maturation of germinal B Cells

25
Q

IL-4 signal CSR

A

IgG1, IgE

26
Q

TGF-Beta Signal CSR

A

IgA and IgG2b

27
Q

IL-5 signal CSR

A

IgA

28
Q

IFN-gamma signal CSR

A

IgG3,IgG2a

29
Q

IgM Tissue Distribution:

A

Serum and mucosal

30
Q

IgM Antibody-Mediated Effector Functions

A

Neutralization +
Agglutination ++
Opsonization +
Complement Fixation +
Stimulates Phagocytosis ++

31
Q

IgD tissue distribution:

A

Serum & upper respiratory tract

32
Q

IgD Antibody-Mediated Effector Functions

A

Neutralization +
Agglutination +
Opsonization +
Granulocyte Degranulation +

33
Q

IgG Tissue distribution

A

Serum

34
Q

IgG Antibody-Mediated Effector Functions

A

Neutralization +
Agglutination +
Opsonization +
Complement Fixation +
Crosses Placenta +
ADCC +
Stimulates Phagocytosis ++

35
Q

IgE Tissue Distribution

A

Serum

36
Q

IgE Antibody-Mediated Effector Functions

A

Neutralization +
Agglutination +
Opsonization +
Granulocyte Degranulation ++

37
Q

IgA tissue distribution:

A

Secretions, serum, and mucosal.

38
Q

IgA Antibody-Mediated Effector Functions

A

Neutralization +
Agglutination +
Opsonization +
ADCC +
Stimulates Phagocytosis +
Granulocyte Degranulation +

39
Q

PolylgR

A
  • Expressed by epithelial cells
  • Initiates transport of IgA and IgM from blood to lumen multiple tissues.
  • IgA in gut to protect from ingested microbes and toxins
40
Q

FcRn (Neonatal Fc receptor)

A
  • related to MHC class I
  • expressed on many different cell types early in an organism’s life span.
    • epithelial/endothelial cells
  • Carry Ab in milk across epithelial cells of the intestine into bloodstream. (IgG) (
41
Q

FcyR

A
  • Most diverse FcRs
  • Main mediators of Ab functions in the body
  • Expressed by a wide range of cells
  • induce phagocytosis if expressed by macrophages
  • induce degranulation if expressed by cytotoxic cells
    (IgG)
42
Q

FcER

A
  • Expressed by granulocytes
  • Triggers a signaling cascade that releases histamines, proteases, & other inflammatory mediators
  • Most often associated with allergy symptoms
    IgE

Immunology (2 decks)

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