Effector T Helper Subsets & Cytokine Ab Isotypes

Question 1

Polarizing cytokines Th1

Answer 1

IL-12, IFN-gamma, and IL-18

Question 2

Master Transcriptional Regulator Th1

Answer 2

T-Bet

Question 3

Effector cytokines Th1

Answer 3

IFN-gamma and TNF-alpha

Question 4

Effector function Th1

Answer 4

Combats intracellular pathogens and activates macrophages.

Question 5

Role in disease Th1

Answer 5

Tissue inflammation

Question 6

Polarizing cytokines Th2

Answer 6

IL-4

Question 7

Master Transcriptional regulator Th2

Answer 7

GATA3

Question 8

Effector cytokines Th2

Answer 8

IL-4, IL-5, and IL-13

Question 9

Effector functions Th2

Answer 9

Combats helminth (worm) infection, activates eosinophils.

Question 10

Role in disease Th2

Answer 10

Allergy

Question 11

Polarizing cytokines Th17

Answer 11

IL-23, IL-6, and TGF-Beta

Question 12

Master transcriptional regulator Th17

Answer 12

RORyt

Question 13

Effector cytokines Th17

Answer 13

IL-17 and IL-22

Question 14

Effector function Th17

Answer 14

Combats extracellular pathogens FUNGAL

Question 15

Role in disease Th17

Answer 15

Autoimmunity

Question 16

Polarizing cytokines ThREG

Answer 16

IL-2, TGF-Beta

Question 17

Master transcriptional regulator Threg

Answer 17

FoxP3

Question 18

Effector cytokines Threg

Answer 18

IL-10 and TGF-Beta

Question 19

Effector function Threg

Answer 19

Suppresses immune responses

Question 20

Role in disease Threg

Answer 20

Inhibits anti tumor response

Question 21

Polarizing cytokines Thfh

Answer 21

IL-6 and IL-21

Question 22

Master transcriptional regulator Thfh

Answer 22

Bcl-6

Question 23

Effector cytokines Thfh

Answer 23

IL-4 and IL-21

Question 24

Effector function Thfh

Answer 24

Regulates affinity maturation of germinal B Cells

Question 25

IL-4 signal CSR

Answer 25

IgG1, IgE

Question 26

TGF-Beta Signal CSR

Answer 26

IgA and IgG2b

Question 27

IL-5 signal CSR

Answer 27

IgA

Question 28

IFN-gamma signal CSR

Answer 28

IgG3,IgG2a

Question 29

IgM Tissue Distribution:

Answer 29

Serum and mucosal

Question 30

IgM Antibody-Mediated Effector Functions

Answer 30

Neutralization +
Agglutination ++
Opsonization +
Complement Fixation +
Stimulates Phagocytosis ++

Question 31

IgD tissue distribution:

Answer 31

Serum & upper respiratory tract

Question 32

IgD Antibody-Mediated Effector Functions

Answer 32

Neutralization +
Agglutination +
Opsonization +
Granulocyte Degranulation +

Question 33

IgG Tissue distribution

Answer 33

Serum

Question 34

IgG Antibody-Mediated Effector Functions

Answer 34

Neutralization +
Agglutination +
Opsonization +
Complement Fixation +
Crosses Placenta +
ADCC +
Stimulates Phagocytosis ++

Question 35

IgE Tissue Distribution

Answer 35

Serum

Question 36

IgE Antibody-Mediated Effector Functions

Answer 36

Neutralization +
Agglutination +
Opsonization +
Granulocyte Degranulation ++

Question 37

IgA tissue distribution:

Answer 37

Secretions, serum, and mucosal.

Question 38

IgA Antibody-Mediated Effector Functions

Answer 38

Neutralization +
Agglutination +
Opsonization +
ADCC +
Stimulates Phagocytosis +
Granulocyte Degranulation +

Question 39

PolylgR

Answer 39

• Expressed by epithelial cells
• Initiates transport of IgA and IgM from blood to lumen multiple tissues.
• IgA in gut to protect from ingested microbes and toxins

Question 40

FcRn (Neonatal Fc receptor)

Answer 40

• related to MHC class I
• expressed on many different cell types early in an organism’s life span.
  
  • epithelial/endothelial cells
• Carry Ab in milk across epithelial cells of the intestine into bloodstream. (IgG) (

Question 41

FcyR

Answer 41

• Most diverse FcRs
• Main mediators of Ab functions in the body
• Expressed by a wide range of cells
• induce phagocytosis if expressed by macrophages
• induce degranulation if expressed by cytotoxic cells
  (IgG)

Question 42

FcER

Answer 42

• Expressed by granulocytes
• Triggers a signaling cascade that releases histamines, proteases, & other inflammatory mediators
• Most often associated with allergy symptoms
  IgE