Effect of recreational drugs

Question 1

What is the process of cocaine’s effect on the body?

2

Answer 1

1) Blocks re-uptake of dopa by binding with dopa transporter molecules on terminal buttons
2) Synapse flooded with surplus quantities of dopamine, available to bind w post synaptic receptors = sense of euphoria

Question 2

Evaluate effect of recreational drugs

3

Answer 2

1 common procedure involves lesioning the MCL pathway in mice brains (Schroeder). Neurons unable to produce lvl of dopa associated w reward. Mice fail self administer cocaine intravenously

Human brain = ^complex. Can’t be explained by 1 drug mode of action. Interactions of dopa w other NT systems (GABA) aren’t understood

^Treatment for addiction. Other drugs developed w reverse mode of action. Naloxone blocks opiate receptors/stops morphine from occupying them >withdrawal symptoms

Question 3

What type of effect does cocaine have?

1

Answer 3

• Stimulus effect on CNS, especially mesocorticolimbic pathway

Question 4

What effects does repeated cocaine use have on the body?

2

Answer 4

• Dopa receptors = down-regulated, quan of dopamine declines

- Explains withdrawal, ^doses to get same effects (tolerance^)