efectos adversos/interacciones Flashcards

1
Q

PENICILINAS (EA) -3

A

hipersensibilidad
GI (C diff)
candida

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2
Q

PENICILINAS (ES) - 1

A

citopenias

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3
Q

SINERGIA CON AMINOGLUCÓSIDOS - 3

A

cefalosporinas
penicilinas
carbapenemicos

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4
Q

CEFALOSPORINAS (EA) - 6

A

tromboflebitis
GI
citopenias
eosinofilia
candida
enterococos

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5
Q

CARBAPENÉMICOS (ES) - 6

A

N/V
convulsiones (geria)
candida
enz hepáticas (crono)
leucopenia
eosinofilia

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6
Q

CARBAPENÉMICOS DISMINUYEN [SÉRICA] DE… - 1

A

Valproato

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7
Q

GLUCOPÉPTIDOS (EA) - 4

A

flebitis
hiersensibilidad
sx del hombre rojo
nefrotox

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8
Q

AUMENTA R DE NEFROTOX EN GLUCOPÉPTIDOS - 4

A

Aminoglucósidos
Anfotericina B
Ciclosporina
Furosemida

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9
Q

SINERGIAS DE GLUCOPÉPTIDOS - 4

A

aminoglucósidos
beta-lact
fosfomicina
TMP/SMX

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10
Q

AMINOGLUCÓSIDOS (EA) - 3

A

nefrotox
ototox
bloq neuromusc

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11
Q

ANTAGONISMO DE AMINOGLUCÓSIDOS - 4

A

Cloranfenicol
Macrólidos
Clindamicina
Tetraciclinas

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12
Q

TETRACICLINAS (ES) - 5

A

acumulación en crec de hueso/dientes
hipersensibilidad drma
sínt GI
HIC benigna
anemia hemolítica

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13
Q

TETRACICLINAS + ??? = INSUF RENAL

A

Tiazidas

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14
Q

TETRACICLINAS DISMINUYEN EFICACIA DE…

A

Anticonceptivos VO

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15
Q

TETRACICLINAS AUMENTAN EFECTO DE… - 5

A

Digoxina
Li
Metrotexato
Teofilina
ACO (???)

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16
Q

MACRÓLIDOS (EA) - 3

A

flebitis
GI
ototox

17
Q

¿QUÉ MACRÓLIDO ALARGA EL QT?

A

Claritromicina

18
Q

¿QUÉ CITOCROMO INH LOS MACRÓLIDOS?

A

P450

19
Q

LINCOSAMIDAS (ES) - 5

A

diarrea
N/V
dolor abd
C diff
hepatotox

20
Q

INTERACCIONES DE LINCOSAMIDAS - 2

A

> acción de NEUROBLOQ
< acción de CICLOSPORINA

21
Q

OXAZOLIDINONAS (ES) - 5

A

GI
trombocitopenia reversible (>10d de tx)
> R de IR
neuritis óptica (crono)
polineuritis (crono)

22
Q

INTERACCIONES DE OXAZOLIDINONAS

A

compiten vs cloranfenicol y clindamicina

23
Q

EVITAR OXAZOLIDINONAS CON… - 3

A

tiramina
adrenérgicos
serotoninérgicos (sx seroton)

24
Q

QUINOLONAS (EA) - 3,3

A

N/V
TGI sup
SNC (cabeza, insomnio,mareos)

25
Q

RIFAMICINAS (EA) - 3

A

hipersensibilidad cutánea
hepatotox
orina naranja

26
Q

RIFAMICINAS DISMINUYEN [SÉRICA] DE… - (7)

A

propanolol
corticoides
estrógenos
hipogluc VO
anticonvulsivantes
digoxina
BZD

27
Q

NITROIMIDAZOLES (EA) - 5

A

disulfiram
sabor a metal
N/V
dolor abd
polineuritis (crono)

28
Q

EA DE NITROIMIDAZOLES EN DOSIS ALTAS - 3

A

convulsiones
ataxia
encefalopatía

29
Q

TMP/SMX (ES) - 6

A

exantema
anafilxia
sx Steven-Johnson
eritema nodoso multiforme
citopenia
aumento de enz hepa

30
Q

INTERACCIONES DE TMP/SMX - 3

A

aumenta M de CICLOSPORINA
aumenta tox de AMANTADINA
disminuyen efecto de ACO & TRICÍCLICOS

31
Q

LIPOPÉPTIDOS (EA)

A

miopatía tóx (NO estatinas/fibratos)

32
Q

SINERGIA DE LIPOPÉPTIDOS - 3

A

aminoglucósidos
rifampicina
algunos beta-lact

33
Q

POLIMIXINAS (EA) - 5

A

IRA (necrosis tubular aguda) !!!
SNC (miopx, parestesias facial, vértigo, parálisis)
hipersensibilidad
broncoespasmo !!
colitis pseudomembranosa (C diff)

34
Q

INTERACCIONES DE POLIMIXINAS - 2

A

prolongan relajantes musc
evitar c nefrotox

34
Q

INTERACCIONES DE POLIMIXINAS - 2

A

prolongan relajantes musc
evitar c nefrotox