ED Clinicals Flashcards
At first thought of ACS involvement what do you do?
OMI [O2; Monitors=ECG/CXR]
MONA [Morphine; O2; Nitro ASA]
Troponin sensitivities peak at ? Hrs
3-6 hours
Myoglobin peaks at ? Hrs and is back to NML at ? Hrs
Peaks = 1-4 hours
NML = 24 hours
Anterior
Inferior
Posterior
Lateral
Wall MI Locations?
Anterior = 1 AVL V2 V6
Inferior = 2 3 AVF
Posterior = (I, aVL, V5-6). Reciprocal ST in 3 and AVF
Lateral = depressions in V1-V3
Time frame for PCI and Thrombolytics in chest pain
PCI = 90 minutes
Thrombolytics = 30 mins if PCI is not available
6 contraindications to Thrombolytics in Ischemic stroke?
Prior intracranial hemorrhage (ICH)
Known structural cerebral vascular lesion.
Known malignant intracranial neoplasm.
Ischemic stroke within 3 months.
Suspected aortic dissection.
Active bleeding or bleeding diathesis (excluding menses)
Pitting edema with hx of of CABG with cool extremities and AMS ; what type of shock is suspected
Cardiogenic
Cardiogenic shock treatment
Treatment: Fluid resuscitation, pressors (dopamine), and treat the underlying cause
What type of murmur is assoc with Cardiogenic shock ? And what are the two types of HF
S4 = diastolic HF (HFpEF) ( ejection fraction is usually
normal, impaired relaxation)
S3 = Systolic HF (HFrEF) with volume overload -
tachycardia, tachypnea. (Rapid ventricular filling
during early diastole is the mechanism responsible for
the S3; impaired wall motion/contraction)
What JVD pressure is assoc with Cardiogenic shock?
Greater than 8 cm
Serum BNP will often be what in obese patients?
Low
BNP vs ProBNP levels for HF
BNP > 500 HF likely; BNP <100 HF unlikely
proBNP >900 HF likely; proBNP <300 HF unlikely
CXR findings assoc with HF and Cardiogenic shock
Kerley B Lines
Class 1 HF vs Class 4 HF
Class I (< 5%) without any limitation of physical activity
Class IV (35 - 40 %): Patients who are not only unable to carry on any physical activity
without discomfort but who also have symptoms of heart failure or anginal syndrome
even at rest
Treatment of hypertensive HF
o Nitro—(if HTN) to reduce preload
IV Nitroprusside if need further preload reduction
o Loop diuretics after BP control
Normotensive HF treatment
o Loop diuretics o ACE/ARB not recommended in acute setting (good f/ chronic HF)
o BB not recommended in acute setting
Chronic HF treatment [systolic vs diastolic]
Systolic left heart failure: Ace Inhibitor + β-blocker + Loop Diuretic
Diastolic heart failure: Ace inhibitor + β-blocker or CCB (do not use diuretics in stable
chronic diastolic failure)
What pulmonary capillary wedge pressure is assoc with pulmonary edema
Less than 18 mmHg
What 5 etiologies can present with pulmonary edema
o Cardiac tamponade
o Cardiogenic pulmonary edema (CHF)
o Myocardial Infarction
o Pericarditis
o Myocarditis
Two types of neurally mediated syncope
Vasovagal - neurogenic
Situational - coughing vomiting carotid sinus stimulation
What are three reasons someone might have cardiac syncope
Arrhythmias
Structural obstruction
Severe MI
What population commonly experiences Orthostatic hypotension
Elderly
Diabetics
Taking certain meds; diuretics vasodilators
When is CT not recommended after a syncopal episode
Asx
Insignificant trauma
After normal neuro exam
Cardiomyopathy is often in the absence of what 3 things?
Coronary artery disease
Hypertension
Valvular disease
What physical exam finding is consistent with HOCM
Mid systolic crescendo decrescendo murmur
Decompensating HOCM patients can benefit from what medicine? And what does it do?
BB or Phenylephrine
Maintains sinus rhythm and increases afterload
Long term txm of HOCM
ICD
Restrictive cardiomyopathy is a
Diastolic dysfunction
Restrtrice cardiomyopathy may present like what 4 things?
Exertional dyspnea
Arrhythmia
Crackles
Edema
What are 3 causes for myocarditis
Virus
Bacteria
Cocaine
4 sxs assoc with myocarditis
CP
Friction Rub
Flu Like sxs
New Onset CHF
Since myocarditis is commonly viral what it’s he best acute management
Antivirals
Then VAD/Transplant
How much fluid is physiologic around the heart
Up to 50mL
Acute pericarditis is heard better when?
Sitting up and forward
Txt for acute pericarditis and post MI
Tx: NSAIDS + colchicine; if post MI ASA + colchicine
What vitals are consistent with PE
sxs of shock; SBP<90 x 15min OR HR <40
What rhythm is common in PE
Tachy!
What are 3 big indicators of end organ damage in hypertension
Papilledema
Encephalopathy
Nephropathy
ED Hypertensive treatments of choice based on classification
Urgency = sodium nitroprusside
Emergency = clonidine
Malignant = diastolic over 140; hydralazine
Best treatment for pulmonary hypertension
Tx: Diuretics, O2, tx underlying cause, refer (basically ADHF tx)
Diagnostic criteria for aortic dissection
Diagnostic Criteria (2/3): pain, widened mediastinum, pulse/BP variation (>20mmHg)
Imaging: CXR (>8cm @ T4)
Stanford type A dissection is managed how vs. Type B
Stanford A (ascending aorta): Surgical emergency
Stanford B (descending aorta only): Medical therapy (beta-blockers) unless complications
are present
Study of choice for aortic dissection
CT ; can be diagnosed based off CXR
Management for descending aortic dissection
Tx: morphine, esmolol (goal of 100-120 SBP),
beside TEE in unstable,
CT in stable (SOC)
+/- Nitroprusside after BB
Immediate vascular surgery referral
What is the rule of repair in aortic aneurysm
Surgical repair if > 5.5 cm or expands > 0.5cm in 6mo or >1cm in 1yr
Nml <3cm
Management of aortic aneurysm
Tx: HTN control (BB), statins, quit smoking
What is the PaO2 goal in ARDS
Greater than 60mm
Pleural effusion with sxs of dyspnea at rest ; management?
Thoracentesis
When do you need to act on hemoptysis ; what do yo do
100-1000mL in 24 hours = MASSOIVE
Airway control; intubate ; unstable = bronchoscopy
If stable minor hemoptysis get what?
CXR
What labs should follow a suspected bronchitis induced minor ARDS
CBC
UA
Coags
What is the criteria for admission over PNA
CURB 65
Confusion
Urea [20+]
Respiratory [30+]
Bp [less 90/60]
Age over 65
Greater than 2 consider; greater than 3 ADMIT
Management for community acquired PNA both w/ and w/o comorbids
W/o = macrolide
W/ = B-lactam+Macrolide ; FQ
Location and size needle for thoracentesis
2-3 ICS -mid clavicular
3-4th anterior axillary line
14 gauge 2 inch needle
After Transthoracic procedures get what
CXR or U/s to verify placement
At what time after simple pneumothorax observation can you send home?
3-6Hrs
Acute management of asthma exacerbation
Acute treatment: oxygen, nebulized SABA, ipratropium bromide, and oral steroids
In COPD patients with SaO2 less than 88% do what?
Non invasive positive pressure ventilation
Go to treatments for nausea and vomiting ; antiemetics
Ondansetron
Droperidol
Scopolamine / Prochlerperazine
GI cocktail
Maalox
Droperidol
Viscous lidocaine
What patients presentation gets colon cancer workup
Older than 50 with new onset constipation
CBC CMP TSH
What is considered acute diarrhea
Less than 14 days ; likely VIRAL
sxs of a viral gastroenteritis
Viral = secretory, nonbloody +/- nonbilious nonbloody vomiting
Lack of fever, no severe systemic sx except in kids <2 yrs
What is the difference between loperamide and pepto bismol
Loperamide = Anti-motility (think movement of bowel contents) vs
Anti-secretory (think acid secretion)
Good ABX for bacterial [travelers] diarrhea
CIPRO 500mg BID or AZITHROMYCIN QD x 3 days ;
Diarrheal treatment if you suspect parasites
Metronidazole 750 mg TID x 10 days
C Diff management
Metronidazole 500mg TID PO!!!!
Severe = vancomycin 125mg QID PO!!!
What type of bacterial diarrhea is suspected after ABX use?
C Diff
Esophageal varices are commonly due to what ; presents how
Portal hypertension
+/- jaundice ; ascites ; hematemesis
5 differentials for BRBPR
Hemorrhoids
Anal Polyps
Colon Cancer
Fissures
Diverticulosis
Mallory Weiss v Boerhaves
MW = partial thickness tear
Boerhaves = full thickness tear
Think esophageal perforation
When is it okay for expectant txt in swallowed foreign body
Distal to pylorus
Not corroding metal
When is expectant therapy okay with swallowed foreign body
If below the pylorus
Not corroding - metal
Epigastric pain, hunger pangs, postprandial pain ; think what
Peptic ulcer disease
Gold standard = upper GI endoscope
Study of choice for acute pancreatitis ; chronic
CT w/ contrast ;
ERCP
+Grey Turner/ Cullens sign
Best management for acute pancreatitis
Treatment: IV fluids (best), analgesics, bowel rest
What is boas sign
Referred Right sub scapular pain
Chole!
Presentation of cholecystitis
RUQ pain after a high-fat meal
Low-grade fever, leukocytosis, jaundice
Dx criteria and best test for cholecystitis
Ultrasound SOC - gallbladder wall >3 mm, pericholecystic fluid, gallstones
HIDA is the best test (Gold Standard) - when ultrasound is inconclusive
CT scan - alternative, more sensitive for perforation, abscess, pancreatitis
Choledocholithiasis gold standard dx
ERCP
60 % of acute cholangitis due to what
Choledocholithiasis
Organisms that commonly cause acute cholangitis (4)
Organisms: E. coli, Enterococcus, Klebsiella, Enterobacter
Organisms commonly responsible for acute cholangitis
Organisms: E. coli, Enterococcus, Klebsiella, Enterobacter
Charcots vs Reynolds’s pentad
Charcots = Jaundice + RUQ pain + Fever
Reynolds = + hypotension + AMS
Management for acute cholangitis
Treatment: ERCP, Cipro + metronidazole, fluids, analgesia, cholecystectomy (performed post-acute)
Explain prehepatic ; intra-hepatic; post-hepatic jaundice
PRE = hemolytic ; RBC breakdown ; dark urine/dark stool
INTRA = LIVER Hepatitis / ETOH / Cirrhosis ;
POST = obstructive ; cholestasis/pancreatic cancer; dark urine/white stools
Increased AST / ALT ; 2:1 think
ETOH
Increased ALT and AST > 1000 think?
Acute hepatitis
Increased ALT : AST but less than 500 ; think?
Chronic hepatitis
Dark urine represents what?
Increased direct bilirubin
Dark urine represents what?
Increased direct bilirubin
Increased bilirubin without increased LFTs =
suspected familial bilirubin disorders
(gilbert’s, Dubin-johnsons) and hemolysis
What is psoas sign fro acute appendicitis
RLQ pain with hip extension
What will the CT show for diverticulitis
Fat stranding and bowel wall thickening
Management for diverticulitis ; sxs abscess, fistula, perf, phlegmon, intractable n/v, immunocomp; no bleeding !!!
Tx: Metro + Cipro, pain control, liquid diet or foods as tolerated ; colonoscopy 6wks post
flare to eval f/ CA
MC cause of SBO vs LBO
SBO = adhesions or hernias, cancer, IBD, volvulus, and intussusception
LBO = cancer, strictures, hernias, volvulus, and fecal impaction
Do not excise hemorrhiods if?
ED if immunocomp, children, pregnancy, portal htn, on
anticoags, coagulopathy
When thinking of prerenal AKI think what? Labs? TXM?
Due to hypoperfusion: Hypovolemia MC, NSAIDs, IV Contrast, ACEI, ARBS (renal artery
stenosis), HF, low BP;
Labs: BUN/Cr > 20:1; Fractional excretion of sodium is normal
TXM? IVF
Intrinsic kidney injury think? Labs? TXM?
Nephrotoxic drugs= aminoglycosides (Gentamicin), Cyclosporine, Tumor lysis syndrome,
Vasculitis (SLE, Sarcoidosis), crystals from gout, myoglobin from rhabdomyolysis
Labs: BUN/Cr < 20:1; Fractional excretion of sodium is elevated
TX: IVF + diuretics to get the kidneys moving
Cellular casts by presentation
WBC casts =
RBC cast=
Muddy casts =
Hyaline casts =
Waxy =
WBC casts = pyelonephritis
RBC cast= glomerulonephritis
Muddy casts = ATN
Hyaline casts = normal
Waxy = chronic renal disease
Postrenal causes of AKI
Obstruction: kidney stones, BPH, tumors, congenital or structural abnormalities
AKI’s can cause what 3 things
ATN
Glomerulonephritis
Interstitial nephritis
ATN presentation
Damaged tubules means can’t concentrate urine = high FENa
Prerenal failure is MC cause
leads to intrinsic injury
Drugs: amp B, cisplatin, aminoglycosides, NSAIDs, ACE
Ischemic: dehydration, shock, sepsis
Interstitial nephritis
Immune-mediated response usually to meds
Drugs: PCN, sulfa, NSAIDs, phenytoin
US: WBC casts + eos + hematuria
Dx: renal biopsy, discontinue offending drug, steroids, dialysis if needed, usually self-
Interstitial nephritis presentation?
Immune-mediated response usually to meds
Drugs: PCN, sulfa, NSAIDs, phenytoin
US: WBC casts + eos + hematuria
Dx: renal biopsy, discontinue offending drug, steroids, dialysis if needed, usually self-
Glomerulonephritis: IGA nephropathy, postinfectious, membranoproliferative
Presentation?
UA: oliguria, hematuria, RBC casts
Causes: group A strep, IGA, anti-GBM, ANCA
Post-strep glomerulonephritis = MC infectious cause of acute glomerulonephritis: either
from strep pharyngitis or strep skin infection (impetigo) ⇒ hematuria, HTN, periorbital edema
What is Dx criteria for glomerulonephritis
Dx: proteinuria + RBC in urine; usually caused by group A beta-hemolytic strep
Goal of TXM for rhabdo
Tx: IVF x 24-72h (4mL/kg/h w/ urine output of 3-4mL/kg/h)
What is the most common cause of increased phosphates
Acute renal failure
Hypoparathyroidism ; PTH level controls serum calcium/phosphate
hypocalcemic may have tetany
Major muscle weakness=may manifests as diplopia, low cardiac output, dysphagia, and
respiratory depression due to respiratory muscle weakness.
Mental status changes= confusion, delirium, and coma.
Think?
Hyperphosphatemia
Crush injuries Diabetic ketoacidosis Nontraumatic rhabdomyolysis Overwhelming systemic infections Tumor lysis syndrome Metabolic or respiratory acidosis
All can cause what?
Hyperphosphatemia
TXM for Hyperphosphatemia
IVF + Acetazolamide [phosphate binders]
Causes of hypophosphatemia
Hyperparathyroidism
Alcoholism
Burns
Starvation
CKD
Diuretics
How can hypophosphatemia present clinically?
Anorexia and muscle weakness
Heart failure
Seizures and coma
Osteomalacia
What is defined as hypocalcemia
serum total calcium < 8.4 mg/dL
ionized fraction of calcium < 4.4 mg/dL
What is the MC cause of hypocalcemia
Hypopararthyroidsim
2 signs of low calcium
Trousea’s and Chovsteks ; prolonged QT interval
Hypercalcemia is defined as
serum total calcium > 10.5 mg/dL
ionized fraction of calcium > 5.6 mg/dL
Stones, bones, abdominal groans, psychiatric moans”, EKG: shortened QT interval.
polyuria, constipation, anorexia renal stones muscle weakness, confusion
Think?
Hypercalcemia
TXM of Hypercalcemia
IVF
Furosemide
Pearls: hypercalcemia in the elderly is cancer until proven otherwise Young adults think hyperparathyroidism
Pearls: hypercalcemia in the elderly is cancer until proven otherwise Young adults think hyperparathyroidism
Correcting chronic low sodium can lead to
Osmotic demyelination syndrome
Hyponatremia often presents with what
Hypokalemia
TXM of hyponatremia
Acute treatment=50 mL bolus of 3% saline
Chronic IV NS
5 causes of hypernatrmia
Diabetes insipidous
Fluid loss from vomiting diarrhea
Skin sweating heavy!
DKA or HHG
elderly lack of thirst
What is the progression from hyperkalemia with EKG changes
sine waves, V-tach and V-Fib
Treatment for hyperkalemia
C BIG K
IV Insulin, Glucose, Albuterol, calcium gluconate, Lasix
With Hypokalemia make sure you check what?
Magnesium!