ED and Cards Flashcards
What are the most common complications of HOCM?
arrhythmias
myocardial ischemia
sudden death
What is bicarb in metabolic acidosis?
low bicarb
can check if appropriately compensating with Winter’s formula
pCO2 = 1.5(HCO3) + 8
* body will never OVER compensate, must be a respiratory component
How to tx unstable angina or non-St elevation Mi inpt?
Admit to ICU/CCU, telemetry
repeat EKG, CPK-MB, troponin at 6 hr intervals
Enoxaparin (though use unfractionated heparin until after procedure if they are going to have one), IV metoprolol, statin oral
What is 3rd degree AV block?
no correlation between the p and qrs waves
How to work up pt with burns from fire?
- check carboxyhemoglobin level *carbon monoxide poisoning
- CXR
- CBC, electrolytes
What are EKG findings of V tach?
- wide QRS
- A-V dissociation
- ischemia findings
- can progress to V fib
- HR usually 100-180
How do you convert an unstable pt with v tach?
start synchronized cardioversion at 100J, then 200J, then 360J, then 360J, if continues - use meds also to stabilize (lidocaine, amiodarone)
What is the work up for a pt with a high fever on CCS of unkown origin?
blood cultures, chest xray, urinalysis
How to read an EKG?
rate (300-150-100-75-60)
rhythm
intervals (PR, QRS (<3 boxes), QT)
T waves
elevations/delta waves
How give stress ulcer prophylaxis?
For all criticall ill pts (ICU)
PPIs, H2 blockers, or sucralfate
What is long term management of hypertensive emergency?
- transfer to floor when symptoms resolve
- start oral meds - labetalol or enalapril
*may beed 2-3 meds (should include diuretic)
How to work up claudication/peripheral vascular dz?
ankle/brachial pressure index (ABI) - do it with a duplex in lower extremities - if <1 = peripheral vascular dz
How do you manage CHF with systolic dysfunction after the pt is stabilized?
- ACE inhibitor
- once stable add beta blockers
- if can’t do ACE inhibitor use hydralazine plus isosorbide dinitrate
- if a fib - start with digoxin
- Spironolactone (if dyspnea at rest or minimum exertion)
How do you differentiate between unstable angina and acute MI?
need troponins and CK-MB
How to treat unstable a fib?
emergency cardioversion for pt with hypotension, AMS, or angina
What rhythm control meds can not be used in QT rolongation because they also prolong QT intervals and can lead to Torsades?
Sotalol, ibutilide, dofetilide
What options can you use for tx for pts with a fib from a rate control perspective?
- Calcium channel Blockers:
Diltiazem just as rapid as verapamil with less side effects
Verapamil (constipation), rapid effect, do not use in pts with low EF bc decr contractility
- Beta-blockes (metoprolol and esmolol) *safe in well controlled asthma and COPD
- Digoxin for rate control in pts with poor EF
what are the indications for thrombolytics in acute MI?
- w/in 12 hours of onset and no access to cath lab for angioplasty
- >1-2 mm ST elevation
- new left bundle branch block (must have an old EKG to compare)
What are the side effects of statins?
myositis and increase in CPK levels
Why are beta blockers contraindicated in anaphylaxis?
they block the action of epinephrine (which is one beta receptors)
What type of antibiotics are given in burn patients?
topical - silver sulfadiazine
How do you treat alcoholic hepatitis (incr. AST/ALT, PT, and bili)?
Steroids (but not if SBP/infection present)
pentoxyphyline - reduces heptorenal syndrome
What is schistocytes a sign of?
microangiopathic hemolytic anemia (red blood cells being ripped apart in small vessels)
Who gets cardioversion in vtach?
hypotension, mental status chages, CHF, chest pain
When shoudl you intubate a burn pt?
airway compromise (stridor)
severely altered mental status
What is the next step in a fib tx if rate and rhythm control don’t work?
ablation
*50% effective
*if 2+ CHAD2S score - anticoagulation is on anticoagulation forever
How do you manage HOCM once stable/dx?
- beta blocker or calcium channel blocker (Verapamil)
- may need implantable defibrillator (based on septum size)
- avoid extreme exertional activity
- surgical fixes: can infuse alcohol to reduce thickness of septum, surgical myomectomy
What is 1st degree AV block?
increased PR interval
How do you surgically tx mitral stenosis?
balloon valvuloplasty or valvular replacement
How do you w/u and manage sudden, symptomatic bradycardia?
- EKG
- Atropine
- IV fluids
stop beta blockers, nitrates, calcium channel blockers when hypotensive
What is the long term management of dyslipidemia?
- statin (high intensity - rosuvastatin, atorvastatin, bring down by 50%, mod intensity reduces by 30-50%)
- limit fats in diet
- exercise (don’t start intense exercise at same time as statin/stagger it)
- LFTs (AST, ALT, bilirubin) q3-6 months
- repeat LDL, Triglycerides, cholesterol levels in 6 wks, then f/u with levels q6-12 months
How do you tx aspirin (salicylate) overdose?
- always give activated charcoal (on CCS for toxicology)
- supportive care (IV hydration)
- IV bicarbonate to alkalinize the urine to increase drug excretion (check urine pH and give until urine pH is > 7.5)
- psych consult
What is f/u management for acute exacerbation of CHF?
- transfer to floor when MI excluded and hypoxia improved
- ECHO when sent to floor
- dobutamine if symptomatic after use of nitrates/furosemide)
- add beta-blockers after stable
- add spironolactone if pt is symptomatic at rest/min exertion
- if still symptomatic after all of this - digoxin
How to manage V tach?
DC cardioversion (unstable), lidocaine or amiodarone (stable), check electrolytes and correct
What is the different between epidural and subdural hematoma?
epidural (convex) - breif period of being well
subdural (lenticular)
What electrolytes can cause QT prolongation?
HypoK
HyopMag
HypoCa
How do you manage CHF with diastolic dysfunction after the pt is stabilized?
- Beta blockers
What is the most common arrythmia?
atrial fibrillation
What type of hypersensitivity reaction is anaphylaxis?
Type 1
Anaphylaxis and atopic
IgE cross linking and immediate release of histamine and bradykinin - increase permeability of capillaries, vasodilation, and bronchoconstriction
delayed response due to production of leukotrienes
What risk factor makes you more likely to get acetaminophen toxicity?
chronic alcohol use (due to increase in P450 acitvation (increase toxic metabolite production) and poor nutrition (decreased glutathione production)
*only 4g per day can lead to acetaminophen toxicity (vs 10-15g/day for other people)
How to control pain in burn patients?
IV morphine drip or PCA pump, or hydromorphone
*if renal failure - use fentanyl
What blood pressure medicine should be used in hypertensive emergency?
- Labetalol
*oral and IV, very safe even in pregnancy - Nitroprusside (only in ICU)
*cyanide poisoning
What is type 3 hypersensitivity?
Immune complex mediated
complexes activate complement which attract neutrophils releasing lysosomal enzymes
ex: SLE, polyarteritis nodosa, post-strep glomerulonephritis
What are thrombolytics used in acute MI?
tPA
streptokinase
What are the 3 things that can give you AST/ALT in the 1000s?
- medications (acetaminophen, methotrexate, RIPE, amiodarone)
- Viral hepatitis (A, B, very rarely C)
- Ischemic liver (after event like v fib/MI)
What genetic syndrome is associated with aortic stenosis?
Turner Syndrome
Labs to check for alcoholics
Electrolytes, blood alchol level, serum magnesium, ABG, AU, blood cultures, LP (if altered mental status)
What usually causes myocardial ST segment elevation vs depression?
ST seg elevation - infarction
ST seg depression - ischemia, or posterior wall MI
What are EKG findings of R ventricular hypertrophy?
R in V1 > 7 mm
Who gets started on a statin?
- anyone with clinical CV disease
- LDL > 190
- person 40-75 yo w/ DM and LDL 70-189 w/o clinical CV disease
- people with/o clinical CV disease or DM who are 40-75 yo with LDL 70-189 w/ a 10 y CV dz risk >7.4% (framingham risk score)
How to work up a pt with a symptomatic tachycardia?
EKG, pulse ox, fluids if hypotensive
How do you initially manage hypertensive emergency?
- EKG
- BUN/Cr, CBC
- IV labetolol, nutroprusside, or enalaprilat
- oxygen and pulse ox
What is the differential for MI?
unstable angina
Acute MI
dissecting aortic aneurysm
pericarditis
esophageal spasms
PE
musculoskeletal pain
pancreatitis
pneumothorax
Who should receive hyperbaric oxygen for pts with carbon monoxide poisoning?
- carboxyhemoglobin >25%
- altered mental status
- angina
- pregnancy with carboxyhemoglobin > 15%
What non-cardiac drugs also block Ca channels and can cause QT prolongation?
macrolides, fluoroquinolones, antipsychotics (haloperidol), methadone
What cardiac drugs should not be used in HOCM?
digoxin
nitrates *causes decr venous return and increased obstruction
vasodilators
ACE inhibitors *incr peripheral resistance
How to manage emergent atrial fibrillation?
IV diltiazem (or verapamil) (CCB)
admit to telemetry unit
What is the difference between action potentials in your heart nodal cells vs the non-nodal cells?
In non-nodal cells, the depolarization is mediated by Na channels (rapid) (then Ca and K come in)
In nodal cells (SA and AV), the depolarization is mediated by Ca channels (slow until meets the threshold, then faster Ca channels open).
What are the most common post MI complications?
arrhythmia (most common in first 3 days)
valvular dysfunction/rupture (3-5 days)
cardiogenic shock
aneurysm formation (delayed)
mural thrombus (at anytime)
myocardial rupture (3-5 days)
conduction defects
How to work up dyspnea with exertion and abnormal cardiac exam in outpt office?
- pulse ox, oxygen
- EKG, CXR, ECHO
How to long can it take for respiratory failure to develop in a burn victim?
6-24 hours
How to work up unstable angina (transient chest pain at rest or worsening pain with exercise)?
aspirin, nitroglycerin, morphine
EKG
CXR
CK-MB and troponin to differentiate bewteen MI and unstable angina
Pre-surgery labs
CBC, PT, Type and Cross
How do you cardiovert a pt who has been in a fib for less than 48hrs?
Usually will cardiovert on their own. But if they don’t, start heparin drip and cardiovert. then go on anticoagulation for weeks.
What is the long term management after acute MI?
beta-blockeres and statins
ACE inhibitors if EF is low (<40%) or sig. anterior wall MI (V1-V4)
Clopidogrel, prasugrel, or ticagrelor for severeal months if a stent is placed
What makes the heart beat faster (mechanism) and slower?
Epi/NE activate B receptors than incr cAMP, which causes repolarization to happen faster in the nodal cells and that incr HR
Actylcholine decreased cAMP and slows repolarization to decr HR (parasympathetic)
What is this rhythm?
V fib
How to work up possible acute MI?
- aspirin
- nitroglycerin (unless contraindicated - hypotensive, murmur, or Hypertrophic obstructive cardiomyopathy)
- morphine (relax the pt)
- EKG - st elevation
- CK-MB (takes 4 hrs to elevate after MI and peaks at 12-18 hrs and lasts 2-3 days)
- troponin (any elevation = damage, stays elevated for 1-2 wks)
- CXR
- pulse ox
When do you see Kerley B lines on CXR?
pulmonary edema
Initial labs in a pt with A fib?
Thyroid function tests (look for thyrotoxicosis)
Cardiac enxymes
ECHO
ABG
What is Type 2 hypersensitivity?
Cytotoxic IgM, IgG bind to fixed antigen
complement mediated lysis - NK cells
ex: autoimmune hemolytic anemia, rheumatic fever, goodpasture’s syndrome, bullous pemphigoid, ITP
What are the common causes of death in the initial period after a 2nd or 3rd degree burn?
hypovolemic shock, infection, airway injury
S4 gallup
“a STIFF heart”