Ecm Flashcards
Define ECM
Non cellular component which is found in all types of cells
Name the two types of ECM
Interstitial connective tissue matrix
Basement membrane
Describe the interstitial connective tissue matrix as ECM
Surrounds cells and provides structural and scaffolding support
Describe the basement membrane in ECM
Separates epithelium and surrounding stroma
What are the main functions of ECM
Tensile strength
Provides support and scaffolding
Determines cells micro environment
In which ways does ecm effect cells microenviroment
Sequesters growth factors
Embryonic development
Residence for roaming phagocytic cells
Migration of cells which is needed in wound repair
Anchors cells through ecm junctions
List ways in which ecm helps maintain micro environment
Sequesters growth factors
Provides residence for roaming phagocytic cells
Determines embryological development
Anchors cells through ecm junctions
Migration of cells which aids in wound repair
Where is ecm located
Cornea
Vitreous body of eye
Blood vessels, tissues and organs
Bone
Tendon
Cartilage
Subcutaneous fat
Dermal layer of skin
Basement membrane
Name the acellular component of ecm
Ground substance
What is ground substance formed of
Proteoglycans
Glycosaminoglycans
Glycoproteins
What is the cellular component of ecm
Fibres
Name two type of fibres which form ecm
Collagen and elastin
Name the repeating part of collagen triple helix
gly-x
What shape does collagen form
Triple helix
In ecm what is the function of collagen
Provides tensile strength
Where is type 1 collagen found
Tendon
Bones
Ligaments
Fibrocartilage
Name the type of collagen found in tendon, bones, ligaments and fibrocartilage
Type 1
Where is type 1 collagen found
Tendon
Ligament
Dermal layer of skin
Fibrocartilage
What type of cartilage is found on tendon, ligaments, Fibrocartilage and dermal layer of skin
Type 1 collagen
Where is type 2 collagen found
Hyaline
What types of collagen is found in hyaline cartilage
Type. 2 collagen
What type of collagen is found in bone marrow, lymphoid organs, reticulin and granulation tissue
Type 3 collagen
Where is type 3 collagen found
Lymphoid organs
Granulation tissue - reticulin
Liver
Bone marrow
What type of collagen is found in liver, bone marrow, granulation tissue such as reticulin and lymphoid organs
Type 3 collagen
What type of collagen is found in the basement membrane
Type 4 collagen
Where is type 4 collagen is found
Basement membrane
Name the type of collagen which is found that links the basement membrane and is found in the cornea
Type 5 collagen
What is the function of collagen in ecm
Provides tensile strength
Describe the arrangement of elastin
Fibrous structure
