ECC boards

Question 0

What makes the tenase complex?

Answer 0

VIIIa and IXa

Question 1

What makes the prothrombinase complex?

Answer 1

Va and Xa

Question 2

Major inhibitor of the extrinsic pathway

Answer 2

Tissue factor pathway inhibitor

Question 3

Natural anticoagulants

Answer 3

Tissue factor pathway inhibitor (extrinsic)
Thrombomodulin (binds thrombin and activates protein C)
Protein C with substrate protein S (inactivates Va and VIIIa)
Antithrombin

Question 4

Antithrombin inhibits what factors…

Answer 4

Xa, IIa, VIIa, IXa, XIa, XIIa

Question 5

What is Scott’s syndrome?

Answer 5

Bleeding disorder - failure to transport phosphatidylserine to surface of activated platelets and to shed membrane-derived PS expressing microparticles

Question 6

MOA chloramphenicol

Answer 6

50s subunit

Question 7

Sulfonamides MOA

Answer 7

Folic acid

Question 8

Two antibiotic classes that act on 30s ribosomal RNA

Answer 8

Aminoglycosides and lincosamides

Question 9

Poiseulle’s Law

Answer 9

Q = (pi) r^4 (P1-P2)/8nl

Q = flow
r = radius of vessel
P1, P2 = pressure at either end of vessel
n = viscosity of blood
l = length of vessel

R = 8nl/(pi)r^4 ….. So radius is major determinant of vascular resistance

Question 10

Newtonian fluid

Answer 10

Fluids in which the viscosity is not directly influenced by absolute velocity