EBM Exam 2 Flashcards
Nominal data
1 confounded
2 samples (independent, parallel design)
Mantel-Haenszel
Nominal data
Greater than 2 confounders
2 samples (independent, parallel design)
Logistic regression
Nominal data
No confounders
2 samples (related, crossover or pre-post design)
McNemar’s test
Nominal data
No confounders
3 or more samples (independent, parallel design)
Chi square (bonferroni)
Nominal data
1 confounder
3 or more samples (independent, parallel design)
Chi square (bonferroni)
Nominal data
2 or more confounders
3 or more samples (independent, parallel design)
Logistic regression
Nominal data
No confounders
3 or more samples (related, cross-over design)
Cochran’s Q (bonferroni)
Ordinal data
No confounders
2 samples (independent, parallel)
Wilcoxon rank sum or Mann Whitney U
Ordinal data
1 confounder
2 samples (independent, parallel)
2 way ANOVA ranks
Ordinal data
2 or more confounders
2 samples (independent, parallel)
ANOVA ranks
Ordinal data
No confounders
2 samples (related, cross-over or pre-post design)
Wilcoxon signed rank test
Ordinal data
1 confounder
2 samples (related, cross-over or pre-post design)
2-way repeated ANOVA ranks
Ordinal data
2 or more confounders
2 samples (related, cross-over or pre-post)
Repeated measures regression
Ordinal data
No confounder
3 or more samples (independent, parallel)
Kruskal-Wallis ANOVA (MCP or bonferroni)
Ordinal data
1 confounder
3 or more samples (independent, parallel)
2 way ANOVA
Ordinal
2 or more confounders
3 or more samples (independent, parallel)
ANCOVA ranks
Ordinal
No confounders
3 or more samples (related, cross-over)
Friedman ANOVA
Ordinal
1 confounder
3 or more samples (related, cross-over)
2 way repeated ANOVA ranks
Ordinal
2 or more confounders
3 or more samples (related, cross-over)
Repeated measures regression
Continuous
No confounders
2 samples (independent, parallel)
Student’s t test
Continuous
1 confounder
2 samples (independent, parallel)
2 way ANOVA
Continuous
2 or more confounders
2 samples (independent, parallel)
ANCOVA
Continuous
No confounders
2 samples (related, cross-over or pre-post)
Paired student’s t test
Continuous
1 confounder
2 samples (related, cross-over or pre-post)
2 way repeated ANOVA
Continuous
2 or more confounders
2 samples (related, cross-over or pre-post)
Repeated measures regression
Continuous
No confounders
3 samples (independent, parallel)
1 way ANOVA (MCP)
Continuous
1 confounder
3 samples (independent, parallel)
2 way ANOVA
Continuous
2 or more confounders
3 samples (independent, parallel)
ANCOVA
Continuous
No confounders
3 samples (related, cross-over)
Repeated measures ANOVA (MCP)
Continuous
1 confounder
3 samples (related, cross-over)
2 way repeated ANOVA
Continuous
2 or more confounders
3 samples (related, cross-over)
Repeated measures regression
Nominal data
No confounders
2 samples (independent, parallel design)
Chi square or fisher’s exact
Mean
Continuous data
Sensitive to outliers
Median
Ordinal and continuous data
Insensitive to outliers
Standard error of the mean
Statistical trick
Makes the variability in the data appear smaller than it is
An estimation of the error in the study’s mean
NOT a measure of variability of the data
Type I error
Claiming that there is a difference when one does not exist
P value
The chance of a type I error occurring
Type II error
Accept null hypothesis when it is false
Power
1-beta
Determine the number of pts needed per group to detect a difference
Smaller differences require larger study pops
P value trumps power or power trumps p value?
P value trumps power – results are still significant if achieve p value but do not achieve power
If confidence interval includes 0 (for absolute values) or 1 (for ratios),
Not statistically significant
Wider CI means
More uncertainty – suspicious of type II error
Problem with relative risk
Artificially inflates effectiveness and adverse events
NNT and NNH can only be calculated for…
NOMINAL data
Statistically significant results
Intention to treat
All data is included in the analysis, regardless of whether the person completed the study
(Real world, more conservative)
Per protocol
Only pts that followed protocol perfectly included in analysis