Earache Flashcards
What are the different anatomic landmarks of the ear? (TN)

What are 4 questions on history that should be asked of all patients presenting with earache?
- Hearing loss
- Tinnitus
- Vertigo
- Aural discharge
What are 2 sources of earache that should always be considered?
- Local
- Referred
What are 9 local causes of earache
- Infection
- Otitis Media
- Otitis Externa
- Malignant Otitis Externa
- Mastoiditis
- Herpes Zoster
- Trauma
- Barotrauma
- Traumatic perforation
- Cerumen impaction
- Wegener’s granulomatosis
- Cholesteatoma
What is mastoiditis? (TN)
- Infection (usually subperiosteal) of mastoid air cells, most commonly seen approximately 2 weeks after onset of untreated or inadequately treated acute suppurative otitis media (same organisms)
What clinical triad is suggestive of mastoiditis? (TN)
- Otorrhea
- Tenderness to pressure over the mastoid
- Retroauricular swelling with protruding ear
- Can also see
- Fever
- Hearing loss
- +/- TM perforation (late)
How is mastoiditis treated? (TN)
- IV antibiotics
- Surgical debridement
How can Herpes Zoster cause earache and what can it be associated with?
- CN VII – can have concurrent Bell’s Palsy with pain and rash
- Associated with vertigo, tinnitus and hearing loss
What are 2 risk factors for malignant otitis externa?
- Diabetes
- Immunocompromise
What are 3 findings associated with malignant otitis externa?
- Refractory OE
- Pain disproportionate
- Granulation tissue on floor of external auditory canal
What is the cause of malignant otitis externa and how is it treated?
- Pseudomonas (99%)
- Admit for IV Cipro
What are 5 findings associated with Wegener’s Granulomatosis?
- Arthralgia
- Hearing loss
- Oral/Nasal ulcers
- Rhinorrhea
- Myalgias
What is the presumed diagnosis for patients presenting with ear discharge (otorrhea) and (conductive) hearing loss?
- Cholesteatoma
What are 5 findings that can be seen with a cholesteatoma?
- Superior TM retraction (retraction pocket)
- Pearly white spots on TM (granulation tissue)
- Foul otorrhea
- TM perforation
- Conductive hearing loss
What are 11 causes of earache due to referred pain?
- The 11 Ts
- Teeth – cavities and abscess
- Tongue
- Trismus – spasm of mastication muscle, early sign of tetanus
- TMJ dysfunction
- Tonsillitis
- Trigeminal neuralgia
- Throat neoplasm
- Risks: alcohol, smoking, age <50
- Refer to ENT
- Tracheitis
- Thyroiditis
- Thoracid aortic aneurysm and CAD
- ECG, CXR, Trop
- Temporal arteritis
- Patient older than 50, PMR, constitutional symptoms, visual disturbances
- Exam: tender artery/scalp, decreased temporal artery pulsation, eye exam
- Get ESR
- *Cervical arthritis
- Referred from C2 and C3 nerve roots
What is the definition of AOM? (DFCM)
- Presence of inflammation in the middle ear accompanied by rapid onset of signs and symptoms of an otalgia and decreased hearing
What is the definition of MEE? (DFCM)
- Presence of fluid in the middle ear without signs and symptoms of an acute ear infection
What are 2 possible causes of MEE? (DFCM)
- Inflammatory response following an episode of AOM
- Spontaneously due to poor Eustachian tube function (post-URTI, seasonal allergies, airplane travel)
What symptoms may children experience with a MEE? (DFCM)
- Transient hearing loss
How can a MEE be diagnosed on examination? (CPS)
- Little or no mobility of the TM when both positive and negative pressure is applied using a pneumatic otoscope
- Loss of bony landmarks
- Presence of an air-fluid level
How long do sterile MEE persist for typically? (DFCM)
- 1 month in 50% of children
- 3 months in 30% of children (10% in MUMS)
- Most resolve over 12 weeks with no intervention necessary
Are decongestants, antihistamines or steroids recommended for MEE? (DFCM)
- Not in children
- Decongestants may offer symptomatic relief in adults
What is the single most effective modifiable risk factor for MEE? (DFCM)
- Discontinue exposure to passive smoking
How should MEE be managed? (DFCM)
- Follow-up recommended at 3 month intervals until the effusion has resolved
- Refer to ENT in the presence of significant hearing loss or structure abnormalities of the tympanic membrane
At what ages do the majority of AOM occur? (DFCM)
- <6 years
What is believed to have lowered the incidence of AOM in Canada? (CPS)
- Pneumococcal vaccine
- PCV7 decreased incidence by 13% to 19%
- PCV13 introduced in 2011 reduced further
What are 11 risk factors for acute otitis media? (CPS)
- Early age of first AOM
- Male sex
- Down’s syndrome
- Orofacial abnormalities (clef palate)
- Daycare attendance
- Household crowding
- Cigarette smoke exposure
- Pacifier use
- Shorter duration of breastfeeding
- Prolonged bottle-feeding while lying down
- Family history of AOM
Why is the incidence of AOM higher in children than adults? (CPS)
- Children acquire viral infections more often
- Can cause Eustachian tube dysfunction or obstruction which impairs the normal mechanism that allows drainage of fluid in the middle ear
- Fluid stasis can be lead to colonization with bacteria
- Children have shorter and more horizontal ETs than adults
What are 6 pathogens that can cause AOM and their relative proportion?
- Steptococcus pneumoniae (40%)
- Nontypeable Haemophilus influenza (25%) – less severe (more likely to resolve)
- Moraxella catarrhalis (10%) – less severe (more likely to resolve)
- Group A Streptococcus (2%)
- Staphylococcus aureus (2%)
- Viral (20-30%)
What are 6 nonspecific symptoms that can be found in AOM? (DFCM)
- Irritability
- Fever
- Night-waking
- Poor feeding
- Cold symptoms
- Conjunctivitis
What is the most sensitive and specific indicator on examination for acute inflammation consistent with AOM? (CPS)
- Bulging TM
What finding on otoscopy also strongly supports a bacterial cause? (CPS)
- Acute perforation with purulent discharge (otorrhea) in the setting of AOM
What are 2 causes of an erythematous TM on examination? (CPS)
- Crying
- Infection
What are 2 aspects required for the diagnosis of AOM on physical exam?
- Diagnosis should NOT be made if there is no middle ear effusion (MEE)
- Diagnosis requires full visualization of ear drum – i.e. no ear wax
What are the 3 diagnostic criteria required to diagnose AOM? (CPS)
- Abrupt onset of symptoms (otalgia or suspected otalgia)
- Middle Ear Effusion (MEE)
- Middle Ear Inflammation (MEI) – doesn’t indicate AOM unless MEE
- Erythema of TM
- Distinct otalgia
- If only fever and a red ear drum, look for another cause
What are 6 findings seen with a Middle Ear Effusion (MEE)?
- Loss of landmarks
- Bulging TM
- Opacity of TM
- Fluid behind TM
- Otorrhea
- Decreased mobility of eardrum on tympanography
For children >6 months of age with suspected AOM that have MEE present AND bulging tympanic membrane, how should they be managed? (CPS)
- Moderately or severely ill = treat
- Irritable, difficulty sleeping, poor response to antipyretics, severe otalgia OR
- ≥39C in ABSENCE of antipyretics OR
- >48h of symptoms
- Mildly ill = observe 24h to 48 h
- Alert, response, no rigors, responding to antipyretics, mild otalgia, able to sleep AND
- <39C in absence of antipyretics AND
- <48h of illness

What are 3 findings that are associated with a diagnosis of moderate-severe AOM?
- Moderate-severe pain
- Pain persisting >48h
- Fever >39
What are 2 considerations in the treatment of AOM?
- Pain management
- Antibiotics
How should pain be treated in patients with AOM?
- Tylenol 15 mg/kg q6h (max 75 mg/kg/day)
- Advil 10mg/kg q6h (max dose 400 mg, max daily dose 40 mg/kg/day)
How should adults with AOM be treated? (DFCM)
- Start antibiotic therapy immediately
- If no improvement in 48-72 hours, patient should be re-examined as there may be a new focus of infection or inadequate therapy
In which situations and ages should children with AOM be treated with antibiotics?
Age
Uncertain Dx
Unilateral AOM without Otorrhea
Bilateral AOM without Otorrhea
Severe Symptoms
Otorrhea (perforation)
<6 months
Antibiotics for 10d
Antibiotics for 10d
Antibiotics for 10d
Antibiotics for 10d
Antibiotics for 10d
6 to 23 months
Severe: Antibiotics 10d
Non-severe: Tylenol
Severe: Antibiotics 10d
Non-severe: Tylenol
Antibiotics for 10d
Antibiotics for 10d
Antibiotics for 10d
>2 years
Observe and Tylenol
Severe: Antibiotic 5d
Non-severe: Tylenol
Severe: Antibiotic 5d
Non-severe: Tylenol
Antibiotics for 5 days
Antibiotics for 5-10 days
What % of untreated children have resolution of AOM at 7-14 days? (TFP)
- 70%
- 80-90% (DFCM/MUMS)
In which children with suspected AOM can watchful waiting be used? (MUMS)
- Children >2 years of age and previously healthy
- Children 6 months to 2 years IF parents can observe for 48-72 hours
- NOT recommended in children <6 months
What should all parents of children being treated for AOM be told? (MUMS)
- Seek immediate medical reassessment if symptoms worsen or new symptoms appear (e.g. rash, drowsiness, difficulty breathing, vomiting)
- If symptoms do not improve after 48 hours (fever, ear pain, fussiness) then return for reassessment and likely start antibiotics
- 24-48h (CPS)
What is the recommended duration of antibiotic therapy for children with AOM? (MUMS/CPS)
- 5 days = >2 years
- 10 days = 6 months to 2 years
- 10 days = <6 months
What is the first-line antibiotic for the treatment of AOM in adults and children? (MUMS/CPS)
- Adults: Amoxicillin 500 mg TID
- Children: Amoxicillin 80 mg/kg/day divided BID or TID (max 3g per day) if no previous amoxicillin in the last 30 days
What is the second-line antibiotic for the treatment of AOM and its indication? (MUMS)
- Adults: Amoxicillin-Clavulin 500 mg TID or 875 mg TID
- Adults: Cefprozil 250-500 mg BID
- Children: Amoxicillin-Clavulin 40-80 mg/kg/day divided BID (max 3g per day)
- Recent Amoxicillin
- Concurrent purulent conjunctivitis – more likely H. influenza or M catarrhalis
- Recurrent AOM unresponsive to Amoxicillin – may be H. influenza or M catarrhalis
- Children: Cefprozil 30 mg/kg/day divided BID
- History of hypersensitivity to penicillins UNLESS previous reaction was life-threatening (i.e. angioedema, bronchospasm or hypotension)
How do the doses recommended by the CPS differ from MUMS for treating AOM? (CPS)
- Amoxicillin 45-60 mg/kgday divided TID as capsules or suspension
How can Amoxicillin-Clavulin be prescribed to increase tolerance? (MUMS)
- BID – reduces total amount of Clavulin
What is the preferred Amoxicllin-Clavulin suspension for treatment of AOM in children and why? (CPS)
- 7:1 formulation (most amoxicillin combined with the least amount of clavulin)
- Each 5 mL of suspension contains 400 mg amoxicillin and 57 mg clavulanate
- <10 mg/kg/day dose of clavulanate associated with higher risk of diarrhea
- For a child weight ≤35 kg, 45-60 mg/kg/day divided TID for 10 days
- Specify 400 mg/5 mL suspension of 7:1 formulation
- For a children weight >35 kg, 500 mg tablets TID a day for 10 days
What are third-line antibiotics for the treatment of AOM and their indications?
- Azithromycin 10 mg/kg/day x1 and 5 mg/kg/day x4
- Penicillin allergy
- Septra 5-10 mg/kg/day divided BID
- Penicillin allergy
- Use for 10 days if first-line failure
How fast should symptoms improve and resolve after starting antimicrobials for AOM? (CPS)
- Improve within 24h
- RTC if no improvement within 24-48h
- Resolve within 2-3 days
What should all children with a perforated TM who present with symptoms of AM be treated with? (CPS)
- Systemic antimicrobials
- Examine for associated complications
What is the preferred treatment for uncomplicated AOM in the presence of a chronic TM perforation or ventilation tubes? (MUMS)
- Ciprodex 4 drops BID for 5 days
- Superior to oral AM/CL in the median time to cessation of otorrhea (4 days vs 7 days), clinical cure rates (85% vs 59%) and adverse effects profile
In which situations could Ciprodex be prescribed for AOM and what is the dose?
- Ciprodex 4 drops BID for 5-10 days
- Perforation
- Venting tubes
What should patients with otitis media with tympanic membrane perforation try to avoid? (DFCM)
- Prevention of water entry into canal
What is the NNT for antibiotics for AOM in children? (TFP)
- NNT = 3 to 10
What are the risks (NNH) for antibiotics prescribed for AOM in children? (TFP)
- Diarrhea NNH = 5
- Diaper rash NNH = 7
- Eczema NNH = 19
What is the evidence for delayed prescription of antibiotics for AOM in children? (TFP)
- 4 studies
- 2 studies found no difference
- 2 studies found immediate prescriptions superior (NNT=6-7)
- Delayed prescriptions may increase patient dissatisfaction
Are prophylactic antibiotics for recurrent AOM appropriate? (MUMS)
- No
- Decrease ~1 episode per year vs Antibiotic Resistance
What is the most common complication of AOM? (CPS)
- Acute mastoiditis
What are 6 potential complications of AOM? (CPS)
- Meningitis
- Facial weakness or paralysis (CN VII palsy)
- Failure of ipsilateral eye abduction due to petrous bone inflammation or infection (CN VI palsy) = Gradenigo’s syndrome
- Labyrinthitis or Vertigo (infection spreads to the cochlear space)
- Hearing loss
- Venous sinus thrombosis of the transverse, lateral or sigmoid venous sinuses
What are 3 indications for tympanostomy tubes?
- 3 episodes of AOM in 6 months
- 4 episodes of AOM in 12 months, with 1 episode in the last 6 months
- OME for ≥3 months with bilateral hearing loss ≥20 dB
What are indications (2) to refer a patient to ENT with a history of AOM?
- Retracted tympanic membrane
- Need to rule out cholesteatoma
- Clef palate or craniofacial malformations or Down syndrome
- Recurrent infections (4 in 1 year, 3 in 6 months)
- Severe signs and symptoms (high fever, intractable pain) despite adequate antibiotic therapy
- Recurrent infections with colonization of multi-drug resistant bacteria
- Persistent TM perforation (>6 weeks) with or without suppurative drainage
- Chronically draining (chronic suppurative otitis media)
- May consider swabbing for possible candida and aspergillus species
How should recurrent AOM be treated?
- Treat with first-line agents if no previous antibiotics in 30 days and previously achieved good effect
- Treat all ages for 10 days
How does chronic perforation or tube ventilation with AOM present and how should it be treated?
- Presents as painless otorrhea
- If no systemic signs – Ciprodex 4 drops BID for 5 days
- Otherwise regular antibiotics for 10 days (All Ages)
What are 5 recommendations that can be may for prevention of AOM?
- Pneumococcal vaccine to all children
- Influenza vaccine to all children
- Encourage breast feeding for 6 months – avoid bottle feeding in supine position
- Avoid pacifiers after 6 months
- Avoid tobacco smoke
What should children with recurrent AOM be tested for?
- Hearing loss
How should children with middle ear effusion (MEE) be followed?
- Reassessed in 3 months for effusion resolution
- 10% will still have effusion – send for hearing test
- Refer if hearing loss
- Avoiding smoke is most effective intervention
- Antihistamines and decongestants cause harm
- 10% will still have effusion – send for hearing test
What is acute otitis externa also called? (CPS)
- Swimmer’s ear
What is the definition of AOE? (DFCM)
- Presence of inflammation in the external auditory canal
At what age is AOE less commonly seen? (CPS)
- Children < 2 years
How can swimming lead to AOE? (CPS)
- Skin desquamation leads to microscopic fissures that provide a portal of entry for infecting organisms
What are 8 risk factors for AOE? (CPS)
- Swimming
- Trauma
- Foreign body
- Hearing aid
- Certain dermatological conditions
- Chronic otorrhea
- Wearing tight head scarves
- Immunocompromised
- Ear piercing à infection of the pinna
What findings are AOE most commonly associated with? (DFCM/CPS)
- Otalgia (70%)
- Pruritus/scaling (60%)
- Aural fullness (22%)
- Hearing loss (32%)
- Ear canal pain with chewing
- Otorrhea
- Diffuse ear canal edema, erythema or both
- Regional lymphadenitis
- Pain with stretching of pinna
- Pain with pushing of tragus
What are 2 signs suggestive of AOE instead of AOM? (CPS)
- Tenderness (out of proportion to visible inflammation) with:
- Tragus push
- Pinna pull
What are 2 precipitants of AOE? (DFCM)
- Excessive moisture
- Moisture removes cerumen and increases the pH of the external canal, providing an ideal environment for pathogen growth and proliferation
- Trauma
- Q-tip use may cause abrasions and allow entry of pathogens to deeper tissue
What are 4 possible causes of AOE? (DFCM)
- Bacterial infection
- Fungal
- Allergic
- Dermatitis
What are the most common bacterial pathogens causing AOE? (DFCM)
- Pseudomonas auruginosa
- Staphylococcus aureus
- 1/3 of cases polymicrobial
How common is fungal AOE and what are the possible causes of it? (DFCM)
- 2-10% of cases
- Occurs after treatment with antibiotics
- Superficial candida can occur in those who use hearing aids due to the moisture
What complication of AOE should be examined for in patients presenting with signs of OE and how should they be managed? (DFCM)
- Necrotizing (Malignant) AOE
- Invasive infection of the external auditory canal with cartilage and bone involvement
- May present with facial nerve palsy and pain as a prominent symptom
- Immediate referral to ENT
What should be done for the management of AOE if there is debris in the ear? (MUMS/CPS)
- Aural toilet
- If severely swollen, Merocel wick is recommended (expandable wick to decrease canal edema and facilitate topical medication delivery
- NO evidence for effectiveness of aural toilet (CPS)
What should be done in a patient with AOE if a defect in the TM cannot be ruled out? (MUMS)
- Proceed as if there is a defect in the TM
How can the external ear canal be cleaned of any debris or cerumen to examine the TM in patients presenting with AOE? (DFCM)
- AVOID using a curette (inflammation can make the canal vulnerable to trauma)
- AVOID flushing unless the TM can be clearly visualized
- Best done with low suction or by using a fluffed-out cotton swab
- Antibiotic drops or hydrogen peroxide may be used to moisten/soften any debris
In which patients should systemic treatments be considered for AOE? (DFCM)
- Diabetes
- History of radiation to ear
- Inflammation extending beyond ear canal
- Significant edema preventing the application of topical therapy
- Immunodeficiency
What would recurrent AOE infections or infections resistant to topical treatment be concerning for? (DFCM)
- Diabetes
- Leukemia
- DiGeorge Syndrome
When would a culture be performed for a patient with suspected AOE? (DFCM)
- Severe OE with fever and lymphadenopathy
What is first-line treatment for AOE with intact TM? (DFCM)
- Buro-Sol 2-3 drops TID or QID ($ cheapest $)
- Contains aluminum acetate and benzethonium chloride
- Less toxic, avoids resistance, lower cost
How effective is Buro-Sol for treating AOE? (CPS)
- Equally effective as topical antimicrobials in clinical cure rates at one week (Cochrane Review)
- Inferior in clinical and microbiological cure at 2-3 weeks (Cochrane Review)
If a patient with suspected AOE has no evidence of dermatitis and only infection, what can be used? (MUMS)
- Polysporin or Polysporin/Lidocaine 1-2 drops QID
What is second-line treatment for AOE with intact TM? (DFCM/MUMS)
- Cortisporin 3 drops TID or QID (4 drops in adults)
- Contains 10,000 U polymyxin, 5 mg neomycin and 10 mg hydrocortisone per mL (ototoxicity)
- Neomycin can be sensitizing when used topically
- Sofracort 2-3 drops TID or QID
- Contains 5 mg framycetin and 0.05 mg gramicidin and 0.5 mg dexamethasone per mL (ototoxicity)
- Garasone 3-4 drops TID
- Contains 3 mg gentamicin and 1 mg betamethasone per mL
- Beware risk of OTOTOXICITY
- Ciprodex 4 drops BID ($$$)
- Contains 3 mg ciprofloxacin and 1 mg dexamethasone per mL
What is first-line treatment for AOE withOUT intact TM? (DFCM/MUMS)
- Ciprodex 4 drops BID ($$$)
For how long should treatment be for mild-to-moderate AOE with topical antibiotics? (CPS)
- 7-10 days
What is the cure rates for topical antimicrobials compared to placebo in the treatment of AOE? (CPS)
- +46% absolute clinical cure rate compared to placebo (Cochrane Review)
- +61% bacteriological cure rate compared to placebo (Cochrane Review)
How soon should patients notice a response with topical antimicrobials for AOE and how long can full response take? (CPS)
- 48-72 hours for clinical response
- 6 days for full response
What should be considered in patients that do not respond to topical antimicrobials? (CPS)
- Obstruction
- Foreign body
- Non-adherence to therapy
- Alternative diagnosis
- Dermatitis from contact with nickel
- Viral infection
- Fungal infection
- Antimicrobial resistance
What are 3 reasons to discontinue treatment for AOE? (DFCM/MUMS)
- Tinnitus
- Hearing loss
- Vertigo or Imbalance
What is the risk associated with prolonged use of combination antibiotics for AOE? (DFCM)
- Alter normal flora and result in a fungal infection
What is first-line treatment for otomycosis? (DFCM/MUMS)
- Clotrimazole 1% cream apply BID (am and qhs)
- Tolnaftate 1% cream apply BID (am and qhs)
- Locacorten Vioform drops 2-3 drops BID
What is second-line treatment for otomycosis? (DFCM)
- Keto-derm apply BID (am and qhs)
When is Keto-derm used for otomycosis as second-line and what does it do? (DFCM)
- Used if no response to above after 1 week
- Contains ketoconazole, which covers for Aspergillus niger
How can AOE be prevented after swimming? (DFCM)
- Remove moisture
- Warm air from a blow dryer
- Tilting the head to allow drainage
- Adding a few drops of vinegar to the ear
- ONLY in the presence of an intact TM