E.7 Thermodynamics

Question 1

What is a drug target?

Answer 1

Usually a macromolecule that is generally much bugger than the drug molecule

Interactions take place in. A binding site

Binding interactions usually result in induced fit, suggesting that the active site changes shape.

Question 2

What interactions take place in the binding of a drug and drug target ?

Answer 2

Intermolecular bonds

Question 3

What are binding interactions driven by?

Answer 3

Thermodynamics and equilibrium

Question 4

If deltaG is negative and large and Keq is large, what does this suggest about the quality and the strength of binding of a drug?

Answer 4

Good drug and binds strongly

Question 5

If you want a drug to be food and bind strongly (have a large and negative delta G) what needs to happen to the enthalpy (delta H) and entropy (delta S)

Answer 5

Delta S is large and negative

And or

Delta S au large and positive

Question 6

What favourable interactions (between the drug and target) is the enthalpy component driven by?

Answer 6

Electrostatic
H-bonds
Van deer walks
Aromatic-aromatic

Question 7

What is the strongest intermolecular interactions ?

Answer 7

Electrostatic