E3 steroids (non specific)

Question 1

Steroids are what analogues
Have what action
How long are the compounds used for
what is their function

Answer 1

Glucocorticoid analogues
Anti-inflammatory action
These compounds used after transplantation, not in long run
Keep immune response suppressed

Question 2

How to steroids reduce inflammation
- what can steroids downregulate

1. what is the direct effect
2. The indirect effect

Answer 2

Inhibit cytokines upstream therefore prevent cytokine induced prostaglandin biosynthesis
- upregulated COX: prevent flow of arachidonic acid (COX becomes deprived)
(annexin 1 - inhibits flux of AA from membrane)

1. inhibition of cytokines
2. inhibition of prostanoids

Question 3

Describe steroid mechanism

Answer 3

Steroids can control regulatory element of DNA

Steroid binds to receptor attached to HSP90 –> binding of steroid disengages receptor and releases receptor-steroid complex –> can translocate to nucleus and bind to regulatory elements of DNA - which are regulated by steroid